DKG-LLM : A Framework for Medical Diagnosis and Personalized Treatment Recommendations via Dynamic Knowledge Graph and Large Language Model Integration

Large Language Models (LLMs) have grown exponentially since the release of ChatGPT. These models have gained attention due to their robust performance on various tasks, including language processing tasks. These models achieve understanding and comprehension of tasks by training billions of parameters. The development of these models is a transformative force in enhancing natural language understanding and has taken a significant step towards artificial general intelligence (AGI). In this study, we aim to present the DKG-LLM framework. The DKG-LLM framework introduces a groundbreaking approach to medical diagnosis and personalized treatment recommendations by integrating a dynamic knowledge graph (DKG) with the Grok 3 large language model. Using the Adaptive Semantic Fusion Algorithm (ASFA), heterogeneous medical data (including clinical reports and PubMed articles) and patient records dynamically generate a knowledge graph consisting of 15,964 nodes in 13 distinct types (e.g., diseases, symptoms, treatments, patient profiles) and 127,392 edges in 26 relationship types (e.g., causal, therapeutic, association). ASFA utilizes advanced probabilistic models, Bayesian inference, and graph optimization to extract semantic information, dynamically updating the graph with approximately 150 new nodes and edges in each data category while maintaining scalability with up to 987,654 edges. Real-world datasets, including MIMIC-III and PubMed, were utilized to evaluate the proposed architecture. The evaluation results show that DKG-LLM achieves a diagnostic accuracy of 84.19%. The model also has a treatment recommendation accuracy of 89.63% and a semantic coverage of 93.48%. DKG-LLM is a reliable and transformative tool that handles noisy data and complex multi-symptom diseases, along with feedback-based learning from physician input.

BrainMetDetect: Predicting Primary Tumor from Brain Metastasis MRI Data Using Radiomic Features and Machine Learning Algorithms

Objective: Brain metastases (BMs) are common in cancer patients and determining the primary tumor site is crucial for effective treatment. This study aims to predict the primary tumor site from BM MRI data using radiomic features and advanced machine learning algorithms. Methods: We utilized a comprehensive dataset from Ocana-Tienda et al. (2023) comprising MRI and clinical data from 75 patients with BMs. Radiomic features were extracted from post-contrast T1-weighted MRI sequences. Feature selection was performed using the GINI index, and data normalization was applied to ensure consistent scaling. We developed and evaluated Random Forest and XGBoost classifiers, both with and without hyperparameter optimization using the FOX (Fox optimizer) algorithm. Model interpretability was enhanced using SHAP (SHapley Additive exPlanations) values. Results: The baseline Random Forest model achieved an accuracy of 0.85, which improved to 0.93 with FOX optimization. The XGBoost model showed an initial accuracy of 0.96, increasing to 0.99 after optimization. SHAP analysis revealed the most influential radiomic features contributing to the models' predictions. The FOX-optimized XGBoost model exhibited the best performance with a precision, recall, and F1-score of 0.99. Conclusion: This study demonstrates the effectiveness of using radiomic features and machine learning to predict primary tumor sites from BM MRI data. The FOX optimization algorithm significantly enhanced model performance, and SHAP provided valuable insights into feature importance. These findings highlight the potential of integrating radiomics and machine learning into clinical practice for improved diagnostic accuracy and personalized treatment planning.