A survey of agent interoperability protocols: Model Context Protocol (MCP), Agent Communication Protocol (ACP), Agent-to-Agent Protocol (A2A), and Agent Network Protocol (ANP)

Large language model (LLM)-powered autonomous agents demand robust, standardized protocols to integrate tools, share contextual data, and coordinate tasks across heterogeneous systems. Ad-hoc integrations are difficult to scale, secure, and generalize across domains. This survey examines four emerging agent communication protocols: Model Context Protocol (MCP), Agent Communication Protocol (ACP), Agent-to-Agent Protocol (A2A), and Agent Network Protocol (ANP), each addressing interoperability in distinct deployment contexts. MCP provides a JSON-RPC client-server interface for secure tool invocation and typed data exchange. ACP introduces REST-native messaging via multi-part messages and asynchronous streaming to support multimodal agent responses. A2A enables peer-to-peer task outsourcing through capability-based Agent Cards, facilitating enterprise-scale workflows. ANP supports open-network agent discovery and secure collaboration using decentralized identifiers (DIDs) and JSON-LD graphs. The protocols are compared across multiple dimensions, including interaction modes, discovery mechanisms, communication patterns, and security models. Based on the comparative analysis, a phased adoption roadmap is proposed: beginning with MCP for tool access, followed by ACP for multimodal messaging, A2A for collaborative task execution, and extending to ANP for decentralized agent marketplaces. This work provides a comprehensive foundation for designing secure, interoperable, and scalable ecosystems of LLM-powered agents.

LLMs in Disease Diagnosis: A Comparative Study of DeepSeek-R1 and O3 Mini Across Chronic Health Conditions

Large Language Models (LLMs) are revolutionizing medical diagnostics by enhancing both disease classification and clinical decision-making. In this study, we evaluate the performance of two LLM- based diagnostic tools, DeepSeek R1 and O3 Mini, using a structured dataset of symptoms and diagnoses. We assessed their predictive accuracy at both the disease and category levels, as well as the reliability of their confidence scores. DeepSeek R1 achieved a disease-level accuracy of 76% and an overall accuracy of 82%, outperforming O3 Mini, which attained 72% and 75% respectively. Notably, DeepSeek R1 demonstrated exceptional performance in Mental Health, Neurological Disorders, and Oncology, where it reached 100% accuracy, while O3 Mini excelled in Autoimmune Disease classification with 100% accuracy. Both models, however, struggled with Respiratory Disease classification, recording accuracies of only 40% for DeepSeek R1 and 20% for O3 Mini. Additionally, the analysis of confidence scores revealed that DeepSeek R1 provided high-confidence predictions in 92% of cases, compared to 68% for O3 Mini. Ethical considerations regarding bias, model interpretability, and data privacy are also discussed to ensure the responsible integration of LLMs into clinical practice. Overall, our findings offer valuable insights into the strengths and limitations of LLM-based diagnostic systems and provide a roadmap for future enhancements in AI-driven healthcare.

Exploring Secure Machine Learning Through Payload Injection and FGSM Attacks on ResNet-50

This paper investigates the resilience of a ResNet-50 image classification model under two prominent security threats: Fast Gradient Sign Method (FGSM) adversarial attacks and malicious payload injection. Initially, the model attains a 53.33% accuracy on clean images. When subjected to FGSM perturbations, its overall accuracy remains unchanged; however, the model's confidence in incorrect predictions notably increases. Concurrently, a payload injection scheme is successfully executed in 93.33% of the tested samples, revealing how stealthy attacks can manipulate model predictions without degrading visual quality. These findings underscore the vulnerability of even high-performing neural networks and highlight the urgency of developing more robust defense mechanisms for security-critical applications.

Exploring Prompt Engineering: A Systematic Review with SWOT Analysis

In this paper, we conduct a comprehensive SWOT analysis of prompt engineering techniques within the realm of Large Language Models (LLMs). Emphasizing linguistic principles, we examine various techniques to identify their strengths, weaknesses, opportunities, and threats. Our findings provide insights into enhancing AI interactions and improving language model comprehension of human prompts. The analysis covers techniques including template-based approaches and fine-tuning, addressing the problems and challenges associated with each. The conclusion offers future research directions aimed at advancing the effectiveness of prompt engineering in optimizing human-machine communication.

Digital Diagnostics: The Potential Of Large Language Models In Recognizing Symptoms Of Common Illnesses

The recent swift development of LLMs like GPT-4, Gemini, and GPT-3.5 offers a transformative opportunity in medicine and healthcare, especially in digital diagnostics. This study evaluates each model diagnostic abilities by interpreting a user symptoms and determining diagnoses that fit well with common illnesses, and it demonstrates how each of these models could significantly increase diagnostic accuracy and efficiency. Through a series of diagnostic prompts based on symptoms from medical databases, GPT-4 demonstrates higher diagnostic accuracy from its deep and complete history of training on medical data. Meanwhile, Gemini performs with high precision as a critical tool in disease triage, demonstrating its potential to be a reliable model when physicians are trying to make high-risk diagnoses. GPT-3.5, though slightly less advanced, is a good tool for medical diagnostics. This study highlights the need to study LLMs for healthcare and clinical practices with more care and attention, ensuring that any system utilizing LLMs promotes patient privacy and complies with health information privacy laws such as HIPAA compliance, as well as the social consequences that affect the varied individuals in complex healthcare contexts. This study marks the start of a larger future effort to study the various ways in which assigning ethical concerns to LLMs task of learning from human biases could unearth new ways to apply AI in complex medical settings.