Metastatic Breast Cancer Prognostication Through Multimodal Integration of Dimensionality Reduction Algorithms and Classification Algorithms

Machine learning (ML) is a branch of Artificial Intelligence (AI) where computers analyze data and find patterns in the data. The study focuses on the detection of metastatic cancer using ML. Metastatic cancer is the point where the cancer has spread to other parts of the body and is the cause of approximately 90% of cancer related deaths. Normally, pathologists spend hours each day to manually classify whether tumors are benign or malignant. This tedious task contributes to mislabeling metastasis being over 60% of time and emphasizes the importance to be aware of human error, and other inefficiencies. ML is a good candidate to improve the correct identification of metastatic cancer saving thousands of lives and can also improve the speed and efficiency of the process thereby taking less resources and time. So far, deep learning methodology of AI has been used in the research to detect cancer. This study is a novel approach to determine the potential of using preprocessing algorithms combined with classification algorithms in detecting metastatic cancer. The study used two preprocessing algorithms: principal component analysis (PCA) and the genetic algorithm to reduce the dimensionality of the dataset, and then used three classification algorithms: logistic regression, decision tree classifier, and k-nearest neighbors to detect metastatic cancer in the pathology scans. The highest accuracy of 71.14% was produced by the ML pipeline comprising of PCA, the genetic algorithm, and the k-nearest neighbors algorithm, suggesting that preprocessing and classification algorithms have great potential for detecting metastatic cancer.

Unveiling Intractable Epileptogenic Brain Networks with Deep Learning Algorithms: A Novel and Comprehensive Framework for Scalable Seizure Prediction with Unimodal Neuroimaging Data in Pediatric Patients

Epilepsy is a prevalent neurological disorder affecting 50 million individuals worldwide and 1.2 million Americans. There exist millions of pediatric patients with intractable epilepsy, a condition in which seizures fail to come under control. The occurrence of seizures can result in physical injury, disorientation, unconsciousness, and additional symptoms that could impede children's ability to participate in everyday tasks. Predicting seizures can help parents and healthcare providers take precautions, prevent risky situations, and mentally prepare children to minimize anxiety and nervousness associated with the uncertainty of a seizure. This research proposes a novel and comprehensive framework to predict seizures in pediatric patients by evaluating machine learning algorithms on unimodal neuroimaging data consisting of electroencephalogram signals. The bandpass filtering and independent component analysis proved to be effective in reducing the noise and artifacts from the dataset. Various machine learning algorithms' performance is evaluated on important metrics such as accuracy, precision, specificity, sensitivity, F1 score and MCC. The results show that the deep learning algorithms are more successful in predicting seizures than logistic Regression, and k nearest neighbors. The recurrent neural network (RNN) gave the highest precision and F1 Score, long short-term memory (LSTM) outperformed RNN in accuracy and convolutional neural network (CNN) resulted in the highest Specificity. This research has significant implications for healthcare providers in proactively managing seizure occurrence in pediatric patients, potentially transforming clinical practices, and improving pediatric care.