Differential Gated Self-Attention

Transformers excel across a large variety of tasks but remain susceptible to corrupted inputs, since standard self-attention treats all query-key interactions uniformly. Inspired by lateral inhibition in biological neural circuits and building on the recent use by the Differential Transformer's use of two parallel softmax subtraction for noise cancellation, we propose Multihead Differential Gated Self-Attention (M-DGSA) that learns per-head input-dependent gating to dynamically suppress attention noise. Each head splits into excitatory and inhibitory branches whose dual softmax maps are fused by a sigmoid gate predicted from the token embedding, yielding a context-aware contrast enhancement. M-DGSA integrates seamlessly into existing Transformer stacks with minimal computational overhead. We evaluate on both vision and language benchmarks, demonstrating consistent robustness gains over vanilla Transformer, Vision Transformer, and Differential Transformer baselines. Our contributions are (i) a novel input-dependent gating mechanism for self-attention grounded in lateral inhibition, (ii) a principled synthesis of biological contrast-enhancement and self-attention theory, and (iii) comprehensive experiments demonstrating noise resilience and cross-domain applicability.

Automated Immunophenotyping Assessment for Diagnosing Childhood Acute Leukemia using Set-Transformers

Acute Leukemia is the most common hematologic malignancy in children and adolescents. A key methodology in the diagnostic evaluation of this malignancy is immunophenotyping based on Multiparameter Flow Cytometry (FCM). However, this approach is manual, and thus time-consuming and subjective. To alleviate this situation, we propose in this paper the FCM-Former, a machine learning, self-attention based FCM-diagnostic tool, automating the immunophenotyping assessment in Childhood Acute Leukemia. The FCM-Former is trained in a supervised manner, by directly using flow cytometric data. Our FCM-Former achieves an accuracy of 96.5% assigning lineage to each sample among 960 cases of either acute B-cell, T-cell lymphoblastic, and acute myeloid leukemia (B-ALL, T-ALL, AML). To the best of our knowledge, the FCM-Former is the first work that automates the immunophenotyping assessment with FCM data in diagnosing pediatric Acute Leukemia.