Simultaneous Dual-View Mammogram Synthesis Using Denoising Diffusion Probabilistic Models

Breast cancer screening relies heavily on mammography, where the craniocaudal (CC) and mediolateral oblique (MLO) views provide complementary information for diagnosis. However, many datasets lack complete paired views, limiting the development of algorithms that depend on cross-view consistency. To address this gap, we propose a three-channel denoising diffusion probabilistic model capable of simultaneously generating CC and MLO views of a single breast. In this configuration, the two mammographic views are stored in separate channels, while a third channel encodes their absolute difference to guide the model toward learning coherent anatomical relationships between projections. A pretrained DDPM from Hugging Face was fine-tuned on a private screening dataset and used to synthesize dual-view pairs. Evaluation included geometric consistency via automated breast mask segmentation and distributional comparison with real images, along with qualitative inspection of cross-view alignment. The results show that the difference-based encoding helps preserve the global breast structure across views, producing synthetic CC-MLO pairs that resemble real acquisitions. This work demonstrates the feasibility of simultaneous dual-view mammogram synthesis using a difference-guided DDPM, highlighting its potential for dataset augmentation and future cross-view-aware AI applications in breast imaging.

Radiology Report Generation with Layer-Wise Anatomical Attention

Automatic radiology report generation is a promising application of multimodal deep learning, aiming to reduce reporting workload and improve consistency. However, current state-of-the-art (SOTA) systems - such as Multimodal AI for Radiology Applications (MAIRA-2) and Medical Pathways Language Model-Multimodal (MedPaLM-M) - depend on large-scale multimodal training, clinical metadata, and multiple imaging views, making them resource-intensive and inaccessible for most settings. We introduce a compact image-to-text architecture that generates the Findings section of chest X-ray reports from a single frontal image. The model combines a frozen Self-Distillation with No Labels v3 (DINOv3) Vision Transformer (ViT) encoder with a Generative Pre-trained Transformer 2 (GPT-2) decoder enhanced by layer-wise anatomical attention. This mechanism integrates lung and heart segmentation masks through hierarchical Gaussian smoothing, biasing attention toward clinically relevant regions without adding trainable parameters. Evaluated on the official Medical Information Mart for Intensive Care-Chest X-ray (MIMIC-CXR) dataset using Chest Radiograph Expert (CheXpert) and Radiology Graph (RadGraph) metrics, our approach achieved substantial gains: CheXpert Macro-F1 for five key pathologies increased by 168% (0.083 -> 0.238) and Micro-F1 by 146% (0.137 -> 0.337), while broader performance across 14 observations improved by 86% (0.170 -> 0.316). Structural coherence also improved, with RadGraph F1 rising by 9.7%. Despite its small size and purely image-conditioned design, the model demonstrates that decoder-level anatomical guidance improves spatial grounding and enhances coherence in clinically relevant regions. The source code is publicly available at: https://github.com/devMuniz02/UDEM-CXR-Reporting-Thesis-2025.