A machine-learning sleep-wake classification model using a reduced number of features derived from photoplethysmography and activity signals

Sleep is a crucial aspect of our overall health and well-being. It plays a vital role in regulating our mental and physical health, impacting our mood, memory, and cognitive function to our physical resilience and immune system. The classification of sleep stages is a mandatory step to assess sleep quality, providing the metrics to estimate the quality of sleep and how well our body is functioning during this essential period of rest. Photoplethysmography (PPG) has been demonstrated to be an effective signal for sleep stage inference, meaning it can be used on its own or in a combination with others signals to determine sleep stage. This information is valuable in identifying potential sleep issues and developing strategies to improve sleep quality and overall health. In this work, we present a machine learning sleep-wake classification model based on the eXtreme Gradient Boosting (XGBoost) algorithm and features extracted from PPG signal and activity counts. The performance of our method was comparable to current state-of-the-art methods with a Sensitivity of 91.15 $\pm$ 1.16%, Specificity of 53.66 $\pm$ 1.12%, F1-score of 83.88 $\pm$ 0.56%, and Kappa of 48.0 $\pm$ 0.86%. Our method offers a significant improvement over other approaches as it uses a reduced number of features, making it suitable for implementation in wearable devices that have limited computational power.

Machine Learning-Based Diabetes Detection Using Photoplethysmography Signal Features

Diabetes is a prevalent chronic condition that compromises the health of millions of people worldwide. Minimally invasive methods are needed to prevent and control diabetes but most devices for measuring glucose levels are invasive and not amenable for continuous monitoring. Here, we present an alternative method to overcome these shortcomings based on non-invasive optical photoplethysmography (PPG) for detecting diabetes. We classify non-Diabetic and Diabetic patients using the PPG signal and metadata for training Logistic Regression (LR) and eXtreme Gradient Boosting (XGBoost) algorithms. We used PPG signals from a publicly available dataset. To prevent overfitting, we divided the data into five folds for cross-validation. By ensuring that patients in the training set are not in the testing set, the model's performance can be evaluated on unseen subjects' data, providing a more accurate assessment of its generalization. Our model achieved an F1-Score and AUC of $58.8\pm20.0\%$ and $79.2\pm15.0\%$ for LR and $51.7\pm16.5\%$ and $73.6\pm17.0\%$ for XGBoost, respectively. Feature analysis suggested that PPG morphological features contains diabetes-related information alongside metadata. Our findings are within the same range reported in the literature, indicating that machine learning methods are promising for developing remote, non-invasive, and continuous measurement devices for detecting and preventing diabetes.

Quality Assessment of Photoplethysmography Signals For Cardiovascular Biomarkers Monitoring Using Wearable Devices

Photoplethysmography (PPG) is a non-invasive technology that measures changes in blood volume in the microvascular bed of tissue. It is commonly used in medical devices such as pulse oximeters and wrist worn heart rate monitors to monitor cardiovascular hemodynamics. PPG allows for the assessment of parameters (e.g., heart rate, pulse waveform, and peripheral perfusion) that can indicate conditions such as vasoconstriction or vasodilation, and provides information about microvascular blood flow, making it a valuable tool for monitoring cardiovascular health. However, PPG is subject to a number of sources of variations that can impact its accuracy and reliability, especially when using a wearable device for continuous monitoring, such as motion artifacts, skin pigmentation, and vasomotion. In this study, we extracted 27 statistical features from the PPG signal for training machine-learning models based on gradient boosting (XGBoost and CatBoost) and Random Forest (RF) algorithms to assess quality of PPG signals that were labeled as good or poor quality. We used the PPG time series from a publicly available dataset and evaluated the algorithm s performance using Sensitivity (Se), Positive Predicted Value (PPV), and F1-score (F1) metrics. Our model achieved Se, PPV, and F1-score of 94.4, 95.6, and 95.0 for XGBoost, 94.7, 95.9, and 95.3 for CatBoost, and 93.7, 91.3 and 92.5 for RF, respectively. Our findings are comparable to state-of-the-art reported in the literature but using a much simpler model, indicating that ML models are promising for developing remote, non-invasive, and continuous measurement devices.