Video-based detection of cessation of breathing in pre-term infants using machine learning

Pre-term infants are susceptible to potentially harmful apnoea-related cessations of breathing due to immature respiratory control. However, reliable respiratory monitoring in the neonatal intensive care unit (NICU) remains challenging because motion artefacts, sensor displacement, and skin fragility can compromise contact-based measurements. Non-contact video monitoring offers a complementary approach that does not depend on adhesive sensors while providing additional respiratory information. We investigated whether camera-based signals can detect apnoea-related cessation of breathing (COBE) and provide complementary information to routinely acquired physiological signals. Using video and clinical recordings from 30 pre-term infants, respiratory motion was extracted from dynamically tracked torso regions to generate camera-derived time-series signals. Camera-only models were trained using residual network (ResNet) architectures, while hybrid models combined video-derived signals with impedance pneumography (IP), ECG-derived respiration (EDR), and the PPG-derived respiratory envelope. Camera-only models achieved a balanced accuracy of 76.9%, demonstrating the feasibility of non-contact COBE detection. Combining video-derived features with IP improved balanced accuracy to 90.6%, outperforming either modality alone and indicating that video provides respiratory information beyond standard physiological signals. These findings show that video-derived signals contain clinically relevant respiratory features and enhance COBE detection when combined with conventional physiological signals. This supports non-contact video as a complementary modality for automated COBE detection and highlights its potential to improve the robustness of neonatal respiratory monitoring.

Deep learning-based detection of cessation of breathing in pre-term infants

Apnoea of prematurity is characterised by recurrent episodes of cessation of breathing and remains difficult to detect reliably using routinely monitored physiological signals in the Neonatal Intensive Care Unit (NICU). Existing bedside monitors rely primarily on respiratory rate and oxygen saturation thresholds, often generating high false-positive alarm rates and missing short or irregular events. Improving automated detection using routinely acquired clinical signals could enhance identification of clinically meaningful events without additional sensing hardware. We evaluated deep learning-based detection of apnoea-related Cessation Of BrEathing (COBE) events using impedance pneumography (IP), electrocardiography (ECG), and photoplethysmography (PPG) signals from approximately 430 hours of NICU recordings collected from 24 pre-term infants. Three independent reviewers annotated COBE events, producing a dataset of 346 COBE and 608 non-COBE events. We compared a shallow convolutional neural network (CNN), residual networks (ResNets), and a ConvNeXt architecture using an independent held-out test set. Across all architectures, detection performance was influenced more strongly by signal modality than by architectural complexity. Unimodal IP-based models achieved balanced accuracies of 86.8-88.0%, outperforming ECG-derived (62.6-69.7%) and PPG-derived (65.1-66.4%) respiratory surrogates. Multimodal fusion yielded modest improvements over IP alone. The best-performing model, a ConvNeXt architecture combining IP and PPG inputs, achieved 88.7% balanced accuracy and an F1 score of 0.75 on the independent test set. These findings demonstrate that deep learning models applied to routinely monitored NICU signals can reliably detect COBE events and highlight the importance of signal modality in data-constrained neonatal monitoring settings.