Template-Fitting Meets Deep Learning: Redshift Estimation Using Physics-Guided Neural Networks

Accurate photometric redshift estimation is critical for observational cosmology, especially in large-scale surveys where spectroscopic measurements are impractical. Traditional approaches include template fitting and machine learning, each with distinct strengths and limitations. We present a hybrid method that integrates template fitting with deep learning using physics-guided neural networks. By embedding spectral energy distribution templates into the network architecture, our model encodes physical priors into the training process. The system employs a multimodal design, incorporating cross-attention mechanisms to fuse photometric and image data, along with Bayesian layers for uncertainty estimation. We evaluate our model on the publicly available PREML dataset, which includes approximately 400,000 galaxies from the Hyper Suprime-Cam PDR3 release, with 5-band photometry, multi-band imaging, and spectroscopic redshifts. Our approach achieves an RMS error of 0.0507, a 3-sigma catastrophic outlier rate of 0.13%, and a bias of 0.0028. The model satisfies two of the three LSST photometric redshift requirements for redshifts below 3. These results highlight the potential of combining physically motivated templates with data-driven models for robust redshift estimation in upcoming cosmological surveys.

GCBLANE: A graph-enhanced convolutional BiLSTM attention network for improved transcription factor binding site prediction

Identifying transcription factor binding sites (TFBS) is crucial for understanding gene regulation, as these sites enable transcription factors (TFs) to bind to DNA and modulate gene expression. Despite advances in high-throughput sequencing, accurately identifying TFBS remains challenging due to the vast genomic data and complex binding patterns. GCBLANE, a graph-enhanced convolutional bidirectional Long Short-Term Memory (LSTM) attention network, is introduced to address this issue. It integrates convolutional, multi-head attention, and recurrent layers with a graph neural network to detect key features for TFBS prediction. On 690 ENCODE ChIP-Seq datasets, GCBLANE achieved an average AUC of 0.943, and on 165 ENCODE datasets, it reached an AUC of 0.9495, outperforming advanced models that utilize multimodal approaches, including DNA shape information. This result underscores GCBLANE's effectiveness compared to other methods. By combining graph-based learning with sequence analysis, GCBLANE significantly advances TFBS prediction.