Complementary, Not Cumulative: Interaction Effects in Physics-Informed Neural Networks for Navier-Stokes Vortex Shedding

Physics-informed neural networks (PINNs) embed governing partial differential equations directly into the training loss, offering a promising alternative to costly CFD solvers for unsteady flows. Yet the growing list of techniques proposed to improve PINN training is typically validated one at a time, leaving open whether these techniques actually compose. We study this question in depth on the DFG/Schafer-Turek unsteady cylinder wake benchmark. In isolation, nearly every technique performs no better than an untreated baseline. However, combining periodic (SIREN) activations with causal weighting unlocks a previously inaccessible regime, reconstructing velocity and pressure fields to within 4.1% average relative L2 error against an OpenFOAM reference solution. Adding further techniques instead causes catastrophic performance degradation, demonstrating that individually effective PINN interventions can interact nonlinearly and that more elaborate training recipes are not necessarily better.

LSM-MS2: A Foundation Model Bridging Spectral Identification and Biological Interpretation

A vast majority of mass spectrometry data remains uncharacterized, leaving much of its biological and chemical information untapped. Recent advances in machine learning have begun to address this gap, particularly for tasks such as spectral identification in tandem mass spectrometry data. Here, we present the latest generation of LSM-MS2, a large-scale deep learning foundation model trained on millions of spectra to learn a semantic chemical space. LSM-MS2 achieves state-of-the-art performance in spectral identification, improving on existing methods by 30% in accuracy of identifying challenging isomeric compounds, yielding 42% more correct identifications in complex biological samples, and maintaining robustness under low-concentration conditions. Furthermore, LSM-MS2 produces rich spectral embeddings that enable direct biological interpretation from minimal downstream data, successfully differentiating disease states and predicting clinical outcomes across diverse translational applications.

ISETHDR: A Physics-based Synthetic Radiance Dataset for High Dynamic Range Driving Scenes

This paper describes a physics-based end-to-end software simulation for image systems. We use the software to explore sensors designed to enhance performance in high dynamic range (HDR) environments, such as driving through daytime tunnels and under nighttime conditions. We synthesize physically realistic HDR spectral radiance images and use them as the input to digital twins that model the optics and sensors of different systems. This paper makes three main contributions: (a) We create a labeled (instance segmentation and depth), synthetic radiance dataset of HDR driving scenes. (b) We describe the development and validation of the end-to-end simulation framework. (c) We present a comparative analysis of two single-shot sensors designed for HDR. We open-source both the dataset and the software.

Using simulation to quantify the performance of automotive perception systems

The design and evaluation of complex systems can benefit from a software simulation - sometimes called a digital twin. The simulation can be used to characterize system performance or to test its performance under conditions that are difficult to measure (e.g., nighttime for automotive perception systems). We describe the image system simulation software tools that we use to evaluate the performance of image systems for object (automobile) detection. We describe experiments with 13 different cameras with a variety of optics and pixel sizes. To measure the impact of camera spatial resolution, we designed a collection of driving scenes that had cars at many different distances. We quantified system performance by measuring average precision and we report a trend relating system resolution and object detection performance. We also quantified the large performance degradation under nighttime conditions, compared to daytime, for all cameras and a COCO pre-trained network.

A Survey on Evaluation Metrics for Synthetic Material Micro-Structure Images from Generative Models

The evaluation of synthetic micro-structure images is an emerging problem as machine learning and materials science research have evolved together. Typical state of the art methods in evaluating synthetic images from generative models have relied on the Fr\'echet Inception Distance. However, this and other similar methods, are limited in the materials domain due to both the unique features that characterize physically accurate micro-structures and limited dataset sizes. In this study we evaluate a variety of methods on scanning electron microscope (SEM) images of graphene-reinforced polyurethane foams. The primary objective of this paper is to report our findings with regards to the shortcomings of existing methods so as to encourage the machine learning community to consider enhancements in metrics for assessing quality of synthetic images in the material science domain.