Explainable Machine-Learning based Detection of Knee Injuries in Runners

Running is a widely practiced activity but shows a high incidence of knee injuries, especially Patellofemoral Pain Syndrome (PFPS) and Iliotibial Band Syndrome (ITBS). Identifying gait patterns linked to these injuries can improve clinical decision-making, which requires precise systems capable of capturing and analyzing temporal kinematic data. This study uses optical motion capture systems to enhance detection of injury-related running patterns. We analyze a public dataset of 839 treadmill recordings from healthy and injured runners to evaluate how effectively these systems capture dynamic parameters relevant to injury classification. The focus is on the stance phase, using joint and segment angle time series and discrete point values. Three classification tasks are addressed: healthy vs. injured, healthy vs. PFPS, and healthy vs. ITBS. We examine different feature spaces, from traditional point-based metrics to full stance-phase time series and hybrid representations. Multiple models are tested, including classical algorithms (K-Nearest Neighbors, Gaussian Processes, Decision Trees) and deep learning architectures (CNNs, LSTMs). Performance is evaluated with accuracy, precision, recall, and F1-score. Explainability tools such as Shapley values, saliency maps, and Grad-CAM are used to interpret model behavior. Results show that combining time series with point values substantially improves detection. Deep learning models outperform classical ones, with CNNs achieving the highest accuracy: 77.9% for PFPS, 73.8% for ITBS, and 71.43% for the combined injury class. These findings highlight the potential of motion capture systems coupled with advanced machine learning to identify knee injury-related running patterns.