Resolving superposition in AI for interpretability and cross-modal alignment in patient-neuronal images

Artificial intelligence is transforming our capability to solve biological challenges. In dimensionality bottleneck regimes exacerbated by high-dimensional biological data, Neural networks force distinct concepts into the lower dimensions known as superposition. Although this superposition is widely known to hinder interpretability, its impact on corrupting the geometry of latent spaces remains critically overlooked. Here, we utilized sparse autoencoders (SAEs) trained on over 100,000 multiplexed images of patient-derived Parkinson's disease and healthy neurons to resolve superposition. This approach bypasses the mathematical non-uniqueness of feature attribution by shifting to interpretable latent representation analysis. We theoretically and empirically demonstrate that superposition contaminates representational metric spaces, and thereby SAEs successfully recover geometric fidelity. By treating these geometrically purified representations as single-cell state vectors, we adapted single-cell RNA sequencing (scRNA-seq) data analysis methodologies directly to the image domain. Finally, we introduce GW-map, utilizing Gromov-Wasserstein optimal transport to align these image representations with authentic scRNA-seq data \emph{de novo}. This coupling reconstructs hierarchical neuronal pathology pathways such as Calcium-AIS scaffold, without reference spatial transcriptomics, establishing a scalable foundation for spatial biology. Code is available at https://github.com/jijihihi/Bio_superposition

Understanding Perspectives of Patients, Caregivers and Clinicians towards Emerging Collaborative-decision Making Technologies

In pediatrics, patients, caregivers, and clinicians share responsibility for health decisions, but limited collaboration can undermine outcomes. We conducted a qualitative study examining decision-makers perceptions toward collaborative decision-making technologies, including interactive dashboards, VR simulators, and AI voice assistants. Findings reveal differences in user opinions across groups and indicate technology acceptance is linked to users trust of these technologies. Technology developers and researchers need to explore design and implementation strategies that build and facilitate trust or appropriate distrust between users and these novel technologies before these tools can effectively support collaborative decision-making.

Toys that listen, talk, and play: Understanding Children's Sensemaking and Interactions with AI Toys

Generative AI (genAI) is increasingly being integrated into children's everyday lives, not only through screens but also through so-called "screen-free" AI toys. These toys can simulate emotions, personalize responses, and recall prior interactions, creating the illusion of an ongoing social connection. Such capabilities raise important questions about how children understand boundaries, agency, and relationships when interacting with AI toys. To investigate this, we conducted two participatory design sessions with eight children ages 6-11 where they engaged with three different AI toys, shifting between play, experimentation, and reflection. Our findings reveal that children approached AI toys with genuine curiosity, profiling them as social beings. However, frequent interaction breakdowns and mismatches between apparent intelligence and toy-like form disrupted expectations around play and led to adversarial play. We conclude with implications and design provocations to navigate children's encounters with AI toys in more transparent, developmentally appropriate, and responsible ways.