Automated Retinal Layer and Fluid Segmentation and Cross-sectional Analysis using Spectral Domain Optical Coherence Tomography Images for Diabetic Retinopathy

This study presents an AI-driven pipeline for automated retinal segmentation and thickness analysis in diabetic retinopathy (DR) using SD-OCT imaging. A deep neural network was trained to segment ten retinal layers, intra-retinal fluid, and hyperreflective foci (HRF), with performance evaluated across multiple architectures. SwinUNETR achieved the highest segmentation accuracy, while VM-Unet excelled in specific layers. Analysis revealed distinct thickness variations between NPDR and PDR, with correlations between layer thickness and visual acuity. The proposed method enhances DR assessment by reducing manual annotation effort and providing clinically relevant thickness maps for disease monitoring and treatment planning.

With Greater Text Comes Greater Necessity: Inference-Time Training Helps Long Text Generation

Long text generation, such as novel writing or discourse-level translation with extremely long contexts, presents significant challenges to current language models. Existing methods mainly focus on extending the model's context window through strategies like length extrapolation. However, these approaches demand substantial hardware resources during the training and/or inference phases. Our proposed method, Temp-Lora, introduces an alternative concept. Instead of relying on the KV cache to store all context information, Temp-Lora embeds this information directly into the model's parameters. In the process of long text generation, we use a temporary Lora module, progressively trained with text generated previously. This approach not only efficiently preserves contextual knowledge but also prevents any permanent alteration to the model's parameters given that the module is discarded post-generation. Extensive experiments on the PG19 language modeling benchmark and the GuoFeng discourse-level translation benchmark validate the effectiveness of Temp-Lora. Our results show that: 1) Temp-Lora substantially enhances generation quality for long texts, as indicated by a 13.2% decrease in perplexity on a subset of PG19, and a 29.6% decrease in perplexity along with a 53.2% increase in BLEU score on GuoFeng, 2) Temp-Lora is compatible with and enhances most existing long text generation methods, and 3) Temp-Lora can greatly reduce computational costs by shortening the context window. While ensuring a slight improvement in generation quality (a decrease of 3.8% in PPL), it enables a reduction of 70.5% in the FLOPs required for inference and a 51.5% decrease in latency.