Error correcting 2D-3D cascaded network for myocardial infarct scar segmentation on late gadolinium enhancement cardiac magnetic resonance images

Late gadolinium enhancement (LGE) cardiac magnetic resonance (CMR) imaging is considered the in vivo reference standard for assessing infarct size (IS) and microvascular obstruction (MVO) in ST-elevation myocardial infarction (STEMI) patients. However, the exact quantification of those markers of myocardial infarct severity remains challenging and very time-consuming. As LGE distribution patterns can be quite complex and hard to delineate from the blood pool or epicardial fat, automatic segmentation of LGE CMR images is challenging. In this work, we propose a cascaded framework of two-dimensional and three-dimensional convolutional neural networks (CNNs) which enables to calculate the extent of myocardial infarction in a fully automated way. By artificially generating segmentation errors which are characteristic for 2D CNNs during training of the cascaded framework we are enforcing the detection and correction of 2D segmentation errors and hence improve the segmentation accuracy of the entire method. The proposed method was trained and evaluated in a five-fold cross validation using the training dataset from the EMIDEC challenge. We perform comparative experiments where our framework outperforms state-of-the-art methods of the EMIDEC challenge, as well as 2D and 3D nnU-Net. Furthermore, in extensive ablation studies we show the advantages that come with the proposed error correcting cascaded method.

A Joint Deep Learning Approach for Automated Liver and Tumor Segmentation

Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer in adults, and the most common cause of death of people suffering from cirrhosis. The segmentation of liver lesions in CT images allows assessment of tumor load, treatment planning, prognosis and monitoring of treatment response. Manual segmentation is a very time-consuming task and in many cases, prone to inaccuracies and automatic tools for tumor detection and segmentation are desirable. In this paper, we use a network architecture that consists of two consecutive fully convolutional neural networks. The first network segments the liver whereas the second network segments the actual tumor inside the liver. Our network is trained on a subset of the LiTS (Liver Tumor Segmentation) challenge and evaluated on data provided from the radiological center in Innsbruck.