Quantum-Enhanced Classification of Brain Tumors Using DNA Microarray Gene Expression Profiles

DNA microarray technology enables the simultaneous measurement of expression levels of thousands of genes, thereby facilitating the understanding of the molecular mechanisms underlying complex diseases such as brain tumors and the identification of diagnostic genetic signatures. To derive meaningful biological insights from the high-dimensional and complex gene features obtained through this technology and to analyze gene properties in detail, classical AI-based approaches such as machine learning and deep learning are widely employed. However, these methods face various limitations in managing high-dimensional vector spaces and modeling the intricate relationships among genes. In particular, challenges such as hyperparameter tuning, computational costs, and high processing power requirements can hinder their efficiency. To overcome these limitations, quantum computing and quantum AI approaches are gaining increasing attention. Leveraging quantum properties such as superposition and entanglement, quantum methods enable more efficient parallel processing of high-dimensional data and offer faster and more effective solutions to problems that are computationally demanding for classical methods. In this study, a novel model called "Deep VQC" is proposed, based on the Variational Quantum Classifier approach. Developed using microarray data containing 54,676 gene features, the model successfully classified four different types of brain tumors-ependymoma, glioblastoma, medulloblastoma, and pilocytic astrocytoma-alongside healthy samples with high accuracy. Furthermore, compared to classical ML algorithms, our model demonstrated either superior or comparable classification performance. These results highlight the potential of quantum AI methods as an effective and promising approach for the analysis and classification of complex structures such as brain tumors based on gene expression features.

Performance Comparison of Different Machine Learning Algorithms on the Prediction of Wind Turbine Power Generation

Over the past decade, wind energy has gained more attention in the world. However, owing to its indirectness and volatility properties, wind power penetration has increased the difficulty and complexity in dispatching and planning of electric power systems. Therefore, it is needed to make the high-precision wind power prediction in order to balance the electrical power. For this purpose, in this study, the prediction performance of linear regression, k-nearest neighbor regression and decision tree regression algorithms is compared in detail. k-nearest neighbor regression algorithm provides lower coefficient of determination values, while decision tree regression algorithm produces lower mean absolute error values. In addition, the meteorological parameters of wind speed, wind direction, barometric pressure and air temperature are evaluated in terms of their importance on the wind power parameter. The biggest importance factor is achieved by wind speed parameter. In consequence, many useful assessments are made for wind power predictions.