TA-RNN-Medical-Hybrid: A Time-Aware and Interpretable Framework for Mortality Risk Prediction

Accurate and interpretable mortality risk prediction in intensive care units (ICUs) remains a critical challenge due to the irregular temporal structure of electronic health records (EHRs), the complexity of longitudinal disease trajectories, and the lack of clinically grounded explanations in many data-driven models. To address these challenges, we propose \textit{TA-RNN-Medical-Hybrid}, a time-aware and knowledge-enriched deep learning framework that jointly models longitudinal clinical sequences and irregular temporal dynamics through explicit continuous-time encoding, along with standardized medical concept representations. The proposed framework extends time-aware recurrent modeling by integrating explicit continuous-time embeddings that operate independently of visit indexing, SNOMED-based disease representations, and a hierarchical dual-level attention mechanism that captures both visit-level temporal importance and feature/concept-level clinical relevance. This design enables accurate mortality risk estimation while providing transparent and clinically meaningful explanations aligned with established medical knowledge. We evaluate the proposed approach on the MIMIC-III critical care dataset and compare it against strong time-aware and sequential baselines. Experimental results demonstrate that TA-RNN-Medical-Hybrid consistently improves predictive performance in terms of AUC, accuracy, and recall-oriented F$_2$-score. Moreover, qualitative analysis shows that the model effectively decomposes mortality risk across time and clinical concepts, yielding interpretable insights into disease severity, chronicity, and temporal progression. Overall, the proposed framework bridges the gap between predictive accuracy and clinical interpretability, offering a scalable and transparent solution for high-stakes ICU decision support systems.

TinyGuard:A lightweight Byzantine Defense for Resource-Constrained Federated Learning via Statistical Update Fingerprints

Existing Byzantine robust aggregation mechanisms typically rely on fulldimensional gradi ent comparisons or pairwise distance computations, resulting in computational overhead that limits applicability in large scale and resource constrained federated systems. This paper proposes TinyGuard, a lightweight Byzantine defense that augments the standard FedAvg algorithm via statistical update f ingerprinting. Instead of operating directly on high-dimensional gradients, TinyGuard extracts compact statistical fingerprints cap turing key behavioral properties of client updates, including norm statistics, layer-wise ratios, sparsity measures, and low-order mo ments. Byzantine clients are identified by measuring robust sta tistical deviations in this low-dimensional fingerprint space with nd complexity, without modifying the underlying optimization procedure. Extensive experiments on MNIST, Fashion-MNIST, ViT-Lite, and ViT-Small with LoRA adapters demonstrate that TinyGuard pre serves FedAvg convergence in benign settings and achieves up to 95 percent accuracy under multiple Byzantine attack scenarios, including sign-flipping, scaling, noise injection, and label poisoning. Against adaptive white-box adversaries, Pareto frontier analysis across four orders of magnitude confirms that attackers cannot simultaneously evade detection and achieve effective poisoning, features we term statistical handcuffs. Ablation studies validate stable detection precision 0.8 across varying client counts (50-150), threshold parameters and extreme data heterogeneity . The proposed framework is architecture-agnostic and well-suited for federated fine-tuning of foundation models where traditional Byzantine defenses become impractical