University of Twente
Abstract:Cardiovascular diseases are the leading cause of death worldwide, and conditions such as arrhythmia often require long-term monitoring for effective detection and diagnosis. However, current wearable monitoring devices are bulky, uncomfortable, and typically rely on clinicians to manually evaluate electrocardiograms (ECGs). While Deep Learning (DL) algorithms have shown superior performance in arrhythmia detection and classification, their computational complexity coupled with high power consumption limit deployment in wearable devices. To address this challenge, this paper investigates the use of approximation techniques to reduce the power and energy consumption of DL architectures while maintaining acceptable classification performance. Specifically, techniques such as data precision reduction and approximate multiplication are investigated in a state-of-the-art DL model and its corresponding hardware architecture. The model is trained and validated using the MIT-BIH Arrhythmia Database, and hardware implementations employing various approximate multipliers are synthesized and evaluated. Compared with the state-of-the-art 8.75 μW (and 2.08 μJ) reference architecture, our proposed architecture consumes 3.07 μW (and 2.17 μJ) at 12 kHz, showing 64.9% reduction in power consumption while providing an acceptable output quality, i.e., 93.7% classification accuracy and 92.1% sensitivity. At 100 MHz, our proposed architecture consumes 9.45 mW (and 0.8 μJ), showing 61.5% reduction in energy consumption as compared to the state-of-the-art architecture. These results demonstrate that our proposed approximations significantly extend wearable device battery life while preserving the required arrhythmia classification performance.
Abstract:Epilepsy is one of the most common neurological disorders globally, characterized by recurring seizures and significantly impacting the quality of life. Despite advancements in diagnostic techniques, the mitigation of risks faced by epilepsy patients remains challenging due to the unpredictability of seizure events. An accurate forecast of seizure onset helps to reduce risks in epilepsy patients. In this paper, we propose EEG-FuseFormer, a transformer-based feature fusion framework for seizure-onset prediction that combines intermediate features extracted from Convolutional Neural Networks-Long Short-Term Memory (CNN-LSTM) and ResNet-18 networks. The CNN-LSTM architecture captures both spatial and temporal features directly from the raw signal, whereas the ResNet-18 extracts features from the Short-Time Fourier Transform (STFT) representation of the EEG signals. Fusion is carried out using a transformer encoder, and the final prediction is generated using fully connected dense layers. The CHB-MIT dataset was used to validate the proposed model. The results show that the proposed model achieves a mean recall of 98.85% and outperforms most of the state-of-the-art methods. This study evaluates the ability of the proposed feature fusion model to generalize in cross-patient testing scenarios. Fine-tuning pre-trained models on limited target patient data (target adaptation) within the cross-patient validation framework results in higher recall, precision, and F1-score metrics in comparison to the conventional cross-patient validation approach. Finally, the runtime-based computational complexity of the model is assessed across diverse hardware platforms to highlight the performance-complexity trade-off.




Abstract:Advancements in deep learning have enabled highly accurate arrhythmia detection from electrocardiogram (ECG) signals, but limited interpretability remains a barrier to clinical adoption. This study investigates the application of Explainable AI (XAI) techniques specifically adapted for time-series ECG analysis. Using the MIT-BIH arrhythmia dataset, a convolutional neural network-based model was developed for arrhythmia classification, with R-peak-based segmentation via the Pan-Tompkins algorithm. To increase the dataset size and to reduce class imbalance, an additional 12-lead ECG dataset was incorporated. A user needs assessment was carried out to identify what kind of explanation would be preferred by medical professionals. Medical professionals indicated a preference for saliency map-based explanations over counterfactual visualisations, citing clearer correspondence with ECG interpretation workflows. Four SHapley Additive exPlanations (SHAP)-based approaches: permutation importance, KernelSHAP, gradient-based methods, and Deep Learning Important FeaTures (DeepLIFT), were implemented and compared. The model achieved 98.3% validation accuracy on MIT-BIH but showed performance degradation on the combined dataset, underscoring dataset variability challenges. Permutation importance and KernelSHAP produced cluttered visual outputs, while gradient-based and DeepLIFT methods highlighted waveform regions consistent with clinical reasoning, but with variability across samples. Findings emphasize the need for domain-specific XAI adaptations in ECG analysis and highlight saliency mapping as a more clinically intuitive approach




Abstract:The growing demand for accurate, continuous, and non-invasive health monitoring has propelled multi-sensor data fusion to the forefront of healthcare technology. This review aims to provide an overview of the development of fusion frameworks in the literature and common terminology used in fusion literature. The review introduces the fusion classification standards and methods that are most relevant from an algorithm development perspective. Applications of the reviewed fusion frameworks in fields such as defense, autonomous driving, robotics, and image fusion are also discussed to provide contextual information on the various fusion methodologies that have been developed in this field. This review provides a comprehensive analysis of multi-sensor data fusion methods applied to health monitoring systems, focusing on key algorithms, applications, challenges, and future directions. We examine commonly used fusion techniques, including Kalman filters, Bayesian networks, and machine learning models. By integrating data from various sources, these fusion approaches enhance the reliability, accuracy, and resilience of health monitoring systems. However, challenges such as data quality and differences in acquisition systems exist, calling for intelligent fusion algorithms in recent years. The review finally converges on applications of fusion algorithms in biomedical inference tasks like heartbeat detection, respiration rate estimation, sleep apnea detection, arrhythmia detection, and atrial fibrillation detection.




Abstract:The abnormal pause or rate reduction in breathing is known as the sleep-apnea hypopnea syndrome and affects the quality of sleep of an individual. A novel method for the detection of sleep apnea events (pause in breathing) from peripheral oxygen saturation (SpO2) signals obtained from wearable devices is discussed in this paper. The paper details an apnea detection algorithm of a very high resolution on a per-second basis for which a 1-dimensional convolutional neural network -- which we termed SomnNET -- is developed. This network exhibits an accuracy of 97.08% and outperforms several lower resolution state-of-the-art apnea detection methods. The feasibility of model pruning and binarization to reduce the computational complexity is explored. The pruned network with 80% sparsity exhibited an accuracy of 89.75%, and the binarized network exhibited an accuracy of 68.22%. The performance of the proposed networks is compared against several state-of-the-art algorithms.




Abstract:Internet of Things (IoT) enabled wearable sensors for health monitoring are widely used to reduce the cost of personal healthcare and improve quality of life. The sleep apnea-hypopnea syndrome, characterized by the abnormal reduction or pause in breathing, greatly affects the quality of sleep of an individual. This paper introduces a novel method for apnea detection (pause in breathing) from electrocardiogram (ECG) signals obtained from wearable devices. The novelty stems from the high resolution of apnea detection on a second-by-second basis, and this is achieved using a 1-dimensional convolutional neural network for feature extraction and detection of sleep apnea events. The proposed method exhibits an accuracy of 99.56% and a sensitivity of 96.05%. This model outperforms several lower resolution state-of-the-art apnea detection methods. The complexity of the proposed model is analyzed. We also analyze the feasibility of model pruning and binarization to reduce the resource requirements on a wearable IoT device. The pruned model with 80\% sparsity exhibited an accuracy of 97.34% and a sensitivity of 86.48%. The binarized model exhibited an accuracy of 75.59% and sensitivity of 63.23%. The performance of low complexity patient-specific models derived from the generic model is also studied to analyze the feasibility of retraining existing models to fit patient-specific requirements. The patient-specific models on average exhibited an accuracy of 97.79% and sensitivity of 92.23%. The source code for this work is made publicly available.