Breast lesion segmentation in ultrasound (US) videos is essential for diagnosing and treating axillary lymph node metastasis. However, the lack of a well-established and large-scale ultrasound video dataset with high-quality annotations has posed a persistent challenge for the research community. To overcome this issue, we meticulously curated a US video breast lesion segmentation dataset comprising 572 videos and 34,300 annotated frames, covering a wide range of realistic clinical scenarios. Furthermore, we propose a novel frequency and localization feature aggregation network (FLA-Net) that learns temporal features from the frequency domain and predicts additional lesion location positions to assist with breast lesion segmentation. We also devise a localization-based contrastive loss to reduce the lesion location distance between neighboring video frames within the same video and enlarge the location distances between frames from different ultrasound videos. Our experiments on our annotated dataset and two public video polyp segmentation datasets demonstrate that our proposed FLA-Net achieves state-of-the-art performance in breast lesion segmentation in US videos and video polyp segmentation while significantly reducing time and space complexity. Our model and dataset are available at https://github.com/jhl-Det/FLA-Net.
Understanding the intricate operations of Recurrent Neural Networks (RNNs) mechanistically is pivotal for advancing their capabilities and applications. In this pursuit, we propose the Episodic Memory Theory (EMT), illustrating that RNNs can be conceptualized as discrete-time analogs of the recently proposed General Sequential Episodic Memory Model. To substantiate EMT, we introduce a novel set of algorithmic tasks tailored to probe the variable binding behavior in RNNs. Utilizing the EMT, we formulate a mathematically rigorous circuit that facilitates variable binding in these tasks. Our empirical investigations reveal that trained RNNs consistently converge to the variable binding circuit, thus indicating universality in the dynamics of RNNs. Building on these findings, we devise an algorithm to define a privileged basis, which reveals hidden neurons instrumental in the temporal storage and composition of variables, a mechanism vital for the successful generalization in these tasks. We show that the privileged basis enhances the interpretability of the learned parameters and hidden states of RNNs. Our work represents a step toward demystifying the internal mechanisms of RNNs and, for computational neuroscience, serves to bridge the gap between artificial neural networks and neural memory models.
Modern DNN-based recommendation systems rely on training-derived embeddings of sparse features. Input sparsity makes obtaining high-quality embeddings for rarely-occurring categories harder as their representations are updated infrequently. We demonstrate a training-time technique to produce superior embeddings via effective cross-category learning and theoretically explain its surprising effectiveness. The scheme, termed the multi-layer embeddings training (MLET), trains embeddings using factorization of the embedding layer, with an inner dimension higher than the target embedding dimension. For inference efficiency, MLET converts the trained two-layer embedding into a single-layer one thus keeping inference-time model size unchanged. Empirical superiority of MLET is puzzling as its search space is not larger than that of the single-layer embedding. The strong dependence of MLET on the inner dimension is even more surprising. We develop a theory that explains both of these behaviors by showing that MLET creates an adaptive update mechanism modulated by the singular vectors of embeddings. When tested on multiple state-of-the-art recommendation models for click-through rate (CTR) prediction tasks, MLET consistently produces better models, especially for rare items. At constant model quality, MLET allows embedding dimension, and model size, reduction by up to 16x, and 5.8x on average, across the models.
Millimeter-wave (mmWave) radar pointcloud offers attractive potential for 3D sensing, thanks to its robustness in challenging conditions such as smoke and low illumination. However, existing methods failed to simultaneously address the three main challenges in mmWave radar pointcloud reconstruction: specular information lost, low angular resolution, and strong interference and noise. In this paper, we propose DREAM-PCD, a novel framework that combines signal processing and deep learning methods into three well-designed components to tackle all three challenges: Non-Coherent Accumulation for dense points, Synthetic Aperture Accumulation for improved angular resolution, and Real-Denoise Multiframe network for noise and interference removal. Moreover, the causal multiframe and "real-denoise" mechanisms in DREAM-PCD significantly enhance the generalization performance. We also introduce RadarEyes, the largest mmWave indoor dataset with over 1,000,000 frames, featuring a unique design incorporating two orthogonal single-chip radars, lidar, and camera, enriching dataset diversity and applications. Experimental results demonstrate that DREAM-PCD surpasses existing methods in reconstruction quality, and exhibits superior generalization and real-time capabilities, enabling high-quality real-time reconstruction of radar pointcloud under various parameters and scenarios. We believe that DREAM-PCD, along with the RadarEyes dataset, will significantly advance mmWave radar perception in future real-world applications.
Text-driven 3D indoor scene generation could be useful for gaming, film industry, and AR/VR applications. However, existing methods cannot faithfully capture the room layout, nor do they allow flexible editing of individual objects in the room. To address these problems, we present Ctrl-Room, which is able to generate convincing 3D rooms with designer-style layouts and high-fidelity textures from just a text prompt. Moreover, Ctrl-Room enables versatile interactive editing operations such as resizing or moving individual furniture items. Our key insight is to separate the modeling of layouts and appearance. %how to model the room that takes into account both scene texture and geometry at the same time. To this end, Our proposed method consists of two stages, a `Layout Generation Stage' and an `Appearance Generation Stage'. The `Layout Generation Stage' trains a text-conditional diffusion model to learn the layout distribution with our holistic scene code parameterization. Next, the `Appearance Generation Stage' employs a fine-tuned ControlNet to produce a vivid panoramic image of the room guided by the 3D scene layout and text prompt. In this way, we achieve a high-quality 3D room with convincing layouts and lively textures. Benefiting from the scene code parameterization, we can easily edit the generated room model through our mask-guided editing module, without expensive editing-specific training. Extensive experiments on the Structured3D dataset demonstrate that our method outperforms existing methods in producing more reasonable, view-consistent, and editable 3D rooms from natural language prompts.
Segmentation and classification of cell nuclei in histopathology images using deep neural networks (DNNs) can save pathologists' time for diagnosing various diseases, including cancers, by automating cell counting and morphometric assessments. It is now well-known that the accuracy of DNNs increases with the sizes of annotated datasets available for training. Although multiple datasets of histopathology images with nuclear annotations and class labels have been made publicly available, the set of class labels differ across these datasets. We propose a method to train DNNs for instance segmentation and classification on multiple datasets where the set of classes across the datasets are related but not the same. Specifically, our method is designed to utilize a coarse-to-fine class hierarchy, where the set of classes labeled and annotated in a dataset can be at any level of the hierarchy, as long as the classes are mutually exclusive. Within a dataset, the set of classes need not even be at the same level of the class hierarchy tree. Our results demonstrate that segmentation and classification metrics for the class set used by the test split of a dataset can improve by pre-training on another dataset that may even have a different set of classes due to the expansion of the training set enabled by our method. Furthermore, generalization to previously unseen datasets also improves by combining multiple other datasets with different sets of classes for training. The improvement is both qualitative and quantitative. The proposed method can be adapted for various loss functions, DNN architectures, and application domains.
Robotic manipulation requires accurate perception of the environment, which poses a significant challenge due to its inherent complexity and constantly changing nature. In this context, RGB image and point-cloud observations are two commonly used modalities in visual-based robotic manipulation, but each of these modalities have their own limitations. Commercial point-cloud observations often suffer from issues like sparse sampling and noisy output due to the limits of the emission-reception imaging principle. On the other hand, RGB images, while rich in texture information, lack essential depth and 3D information crucial for robotic manipulation. To mitigate these challenges, we propose an image-only robotic manipulation framework that leverages an eye-on-hand monocular camera installed on the robot's parallel gripper. By moving with the robot gripper, this camera gains the ability to actively perceive object from multiple perspectives during the manipulation process. This enables the estimation of 6D object poses, which can be utilized for manipulation. While, obtaining images from more and diverse viewpoints typically improves pose estimation, it also increases the manipulation time. To address this trade-off, we employ a reinforcement learning policy to synchronize the manipulation strategy with active perception, achieving a balance between 6D pose accuracy and manipulation efficiency. Our experimental results in both simulated and real-world environments showcase the state-of-the-art effectiveness of our approach. %, which, to the best of our knowledge, is the first to achieve robust real-world robotic manipulation through active pose estimation. We believe that our method will inspire further research on real-world-oriented robotic manipulation.
A pivotal aim in contemporary AI research is to develop agents proficient in multi-agent coordination, enabling effective collaboration with both humans and other systems. Large Language Models (LLMs), with their notable ability to understand, generate, and interpret language in a human-like manner, stand out as promising candidates for the development of such agents. In this study, we build and assess the effectiveness of agents crafted using LLMs in various coordination scenarios. We introduce the LLM-Coordination (LLM-Co) Framework, specifically designed to enable LLMs to play coordination games. With the LLM-Co framework, we conduct our evaluation with three game environments and organize the evaluation into five aspects: Theory of Mind, Situated Reasoning, Sustained Coordination, Robustness to Partners, and Explicit Assistance. First, the evaluation of the Theory of Mind and Situated Reasoning reveals the capabilities of LLM to infer the partner's intention and reason actions accordingly. Then, the evaluation around Sustained Coordination and Robustness to Partners further showcases the ability of LLMs to coordinate with an unknown partner in complex long-horizon tasks, outperforming Reinforcement Learning baselines. Lastly, to test Explicit Assistance, which refers to the ability of an agent to offer help proactively, we introduce two novel layouts into the Overcooked-AI benchmark, examining if agents can prioritize helping their partners, sacrificing time that could have been spent on their tasks. This research underscores the promising capabilities of LLMs in sophisticated coordination environments and reveals the potential of LLMs in building strong real-world agents for multi-agent coordination.
Peptides are formed by the dehydration condensation of multiple amino acids. The primary structure of a peptide can be represented either as an amino acid sequence or as a molecular graph consisting of atoms and chemical bonds. Previous studies have indicated that deep learning routes specific to sequential and graphical peptide forms exhibit comparable performance on downstream tasks. Despite the fact that these models learn representations of the same modality of peptides, we find that they explain their predictions differently. Considering sequential and graphical models as two experts making inferences from different perspectives, we work on fusing expert knowledge to enrich the learned representations for improving the discriminative performance. To achieve this, we propose a peptide co-modeling method, RepCon, which employs a contrastive learning-based framework to enhance the mutual information of representations from decoupled sequential and graphical end-to-end models. It considers representations from the sequential encoder and the graphical encoder for the same peptide sample as a positive pair and learns to enhance the consistency of representations between positive sample pairs and to repel representations between negative pairs. Empirical studies of RepCon and other co-modeling methods are conducted on open-source discriminative datasets, including aggregation propensity, retention time, antimicrobial peptide prediction, and family classification from Peptide Database. Our results demonstrate the superiority of the co-modeling approach over independent modeling, as well as the superiority of RepCon over other methods under the co-modeling framework. In addition, the attribution on RepCon further corroborates the validity of the approach at the level of model explanation.
Brain metastases (BMs) are the most frequently occurring brain tumors. The treatment of patients having multiple BMs with stereo tactic radiosurgery necessitates accurate localization of the metastases. Neural networks can assist in this time-consuming and costly task that is typically performed by human experts. Particularly challenging is the detection of small lesions since they are often underrepresented in exist ing approaches. Yet, lesion detection is equally important for all sizes. In this work, we develop an ensemble of neural networks explicitly fo cused on detecting and segmenting small BMs. To accomplish this task, we trained several neural networks focusing on individual aspects of the BM segmentation problem: We use blob loss that specifically addresses the imbalance of lesion instances in terms of size and texture and is, therefore, not biased towards larger lesions. In addition, a model using a subtraction sequence between the T1 and T1 contrast-enhanced sequence focuses on low-contrast lesions. Furthermore, we train additional models only on small lesions. Our experiments demonstrate the utility of the ad ditional blob loss and the subtraction sequence. However, including the specialized small lesion models in the ensemble deteriorates segmentation results. We also find domain-knowledge-inspired postprocessing steps to drastically increase our performance in most experiments. Our approach enables us to submit a competitive challenge entry to the ASNR-MICCAI BraTS Brain Metastasis Challenge 2023.