Optimistic Optimization of Gaussian Process Samples

Bayesian optimization is a popular formalism for global optimization, but its computational costs limit it to expensive-to-evaluate functions. A competing, computationally more efficient, global optimization framework is optimistic optimization, which exploits prior knowledge about the geometry of the search space in form of a dissimilarity function. We investigate to which degree the conceptual advantages of Bayesian Optimization can be combined with the computational efficiency of optimistic optimization. By mapping the kernel to a dissimilarity, we obtain an optimistic optimization algorithm for the Bayesian Optimization setting with a run-time of up to $\mathcal{O}(N \log N)$. As a high-level take-away we find that, when using stationary kernels on objectives of relatively low evaluation cost, optimistic optimization can be strongly preferable over Bayesian optimization, while for strongly coupled and parametric models, good implementations of Bayesian optimization can perform much better, even at low evaluation cost. We argue that there is a new research domain between geometric and probabilistic search, i.e. methods that run drastically faster than traditional Bayesian optimization, while retaining some of the crucial functionality of Bayesian optimization.

Diffusion-based Molecule Generation with Informative Prior Bridges

AI-based molecule generation provides a promising approach to a large area of biomedical sciences and engineering, such as antibody design, hydrolase engineering, or vaccine development. Because the molecules are governed by physical laws, a key challenge is to incorporate prior information into the training procedure to generate high-quality and realistic molecules. We propose a simple and novel approach to steer the training of diffusion-based generative models with physical and statistics prior information. This is achieved by constructing physically informed diffusion bridges, stochastic processes that guarantee to yield a given observation at the fixed terminal time. We develop a Lyapunov function based method to construct and determine bridges, and propose a number of proposals of informative prior bridges for both high-quality molecule generation and uniformity-promoted 3D point cloud generation. With comprehensive experiments, we show that our method provides a powerful approach to the 3D generation task, yielding molecule structures with better quality and stability scores and more uniformly distributed point clouds of high qualities.

Representation Learning for Non-Melanoma Skin Cancer using a Latent Autoencoder

Generative learning is a powerful tool for representation learning, and shows particular promise for problems in biomedical imaging. However, in this context, sampling from the distribution is secondary to finding representations of real images, which often come with labels and explicitly represent the content and quality of the target distribution. It remains difficult to faithfully reconstruct images from generative models, particularly those as complex as histological images. In this work, two existing methods (autoencoders and adversarial latent autoencoders) are combined in attempt to improve our ability to encode and decode real images of non-melanoma skin cancer, specifically intra-epidermal carcinoma (IEC). Utilising a dataset of high-quality images of IEC (256 x 256), this work assesses the result of both image reconstruction quality and representation learning. It is shown that adversarial training can improve baseline FID scores from 76 to 50, and that benchmarks on representation learning can be improved by up to 3%. Smooth and realistic interpolations of the variation in the morphological structure are also presented for the first time, positioning representation learning as a promising direction in the context of computational pathology.

Design and Development of Miniature long distance multi-moving robots for 3D Smart Sensing for underground Pipe Inspection

Designing an in-pipe climbing robot that manipulates sharp gears to study complex line relationships. Traditional rolling/happening pipe climbing robots tend to slide when exploring pipe curves. The proposed gearbox connects to the farthest ground plane of a standard dual output gearbox. Instrumentation helps achieve a very well-defined deceleration sequence in which the robot slides and pulls as it moves forward. This instrument takes into account the forces exerted on each track within the line relationship and intentionally modifies the robot's track speed, unlocking the key to fine-tuning. This makes the 3 output transmissions take a lot of time. Deflection of the robot on a pipe network with various bearings and non-slip pipe bends demonstrates the integrity of the proposed structure.

A Community-Aware Framework for Social Influence Maximization

We consider the Influence Maximization (IM) problem: 'if we can try to convince a subset of individuals in a social network to adopt a new product or innovation, and the goal is to trigger a large cascade of further adoptions, which set of individuals should we target'? Formally, it is the task of selecting $k$ seed nodes in a social network such that the expected number of influenced nodes in the network (under some influence propagation model) is maximized. This problem has been widely studied in the literature and several solution approaches have been proposed. However, most simulation-based approaches involve time-consuming Monte-Carlo simulations to compute the influence of the seed nodes in the entire network. This limits the applicability of these methods on large social networks. In the paper, we are interested in solving the problem of influence maximization in a time-efficient manner. We propose a community-aware divide-and-conquer strategy that involves (i) learning the inherent community structure of the social network, (ii) generating candidate solutions by solving the influence maximization problem for each community, and (iii) selecting the final set of individuals from the candidate solutions using a novel progressive budgeting scheme. We provide experiments on real-world social networks, showing that the proposed algorithm outperforms the simulation-based algorithms in terms of empirical run-time and the heuristic algorithms in terms of influence. We also study the effect of the community structure on the performance of our algorithm. Our experiments show that the community structures with higher modularity lead the proposed algorithm to perform better in terms of run-time and influence.

Classify Respiratory Abnormality in Lung Sounds Using STFT and a Fine-Tuned ResNet18 Network

Recognizing patterns in lung sounds is crucial to detecting and monitoring respiratory diseases. Current techniques for analyzing respiratory sounds demand domain experts and are subject to interpretation. Hence an accurate and automatic respiratory sound classification system is desired. In this work, we took a data-driven approach to classify abnormal lung sounds. We compared the performance using three different feature extraction techniques, which are short-time Fourier transformation (STFT), Mel spectrograms, and Wav2vec, as well as three different classifiers, including pre-trained ResNet18, LightCNN, and Audio Spectrogram Transformer. Our key contributions include the bench-marking of different audio feature extractors and neural network based classifiers, and the implementation of a complete pipeline using STFT and a fine-tuned ResNet18 network. The proposed method achieved Harmonic Scores of 0.89, 0.80, 0.71, 0.36 for tasks 1-1, 1-2, 2-1 and 2-2, respectively on the testing sets in the IEEE BioCAS 2022 Grand Challenge on Respiratory Sound Classification.

PrePARE: Predictive Proprioception for Agile Failure Event Detection in Robotic Exploration of Extreme Terrains

Legged robots can traverse a wide variety of terrains, some of which may be challenging for wheeled robots, such as stairs or highly uneven surfaces. However, quadruped robots face stability challenges on slippery surfaces. This can be resolved by adjusting the robot's locomotion by switching to more conservative and stable locomotion modes, such as crawl mode (where three feet are in contact with the ground always) or amble mode (where one foot touches down at a time) to prevent potential falls. To tackle these challenges, we propose an approach to learn a model from past robot experience for predictive detection of potential failures. Accordingly, we trigger gait switching merely based on proprioceptive sensory information. To learn this predictive model, we propose a semi-supervised process for detecting and annotating ground truth slip events in two stages: We first detect abnormal occurrences in the time series sequences of the gait data using an unsupervised anomaly detector, and then, the anomalies are verified with expert human knowledge in a replay simulation to assert the event of a slip. These annotated slip events are then used as ground truth examples to train an ensemble decision learner for predicting slip probabilities across terrains for traversability. We analyze our model on data recorded by a legged robot on multiple sites with slippery terrain. We demonstrate that a potential slip event can be predicted up to 720 ms ahead of a potential fall with an average precision greater than 0.95 and an average F-score of 0.82. Finally, we validate our approach in real-time by deploying it on a legged robot and switching its gait mode based on slip event detection.

VISOLO: Grid-Based Space-Time Aggregation for Efficient Online Video Instance Segmentation

For online video instance segmentation (VIS), fully utilizing the information from previous frames in an efficient manner is essential for real-time applications. Most previous methods follow a two-stage approach requiring additional computations such as RPN and RoIAlign, and do not fully exploit the available information in the video for all subtasks in VIS. In this paper, we propose a novel single-stage framework for online VIS built based on the grid structured feature representation. The grid-based features allow us to employ fully convolutional networks for real-time processing, and also to easily reuse and share features within different components. We also introduce cooperatively operating modules that aggregate information from available frames, in order to enrich the features for all subtasks in VIS. Our design fully takes advantage of previous information in a grid form for all tasks in VIS in an efficient way, and we achieved the new state-of-the-art accuracy (38.6 AP and 36.9 AP) and speed (40.0 FPS) on YouTube-VIS 2019 and 2021 datasets among online VIS methods.

On the Horizon: Interactive and Compositional Deepfakes

Over a five-year period, computing methods for generating high-fidelity, fictional depictions of people and events moved from exotic demonstrations by computer science research teams into ongoing use as a tool of disinformation. The methods, referred to with the portmanteau of "deepfakes," have been used to create compelling audiovisual content. Here, I share challenges ahead with malevolent uses of two classes of deepfakes that we can expect to come into practice with costly implications for society: interactive and compositional deepfakes. Interactive deepfakes have the capability to impersonate people with realistic interactive behaviors, taking advantage of advances in multimodal interaction. Compositional deepfakes leverage synthetic content in larger disinformation plans that integrate sets of deepfakes over time with observed, expected, and engineered world events to create persuasive synthetic histories. Synthetic histories can be constructed manually but may one day be guided by adversarial generative explanation (AGE) techniques. In the absence of mitigations, interactive and compositional deepfakes threaten to move us closer to a post-epistemic world, where fact cannot be distinguished from fiction. I shall describe interactive and compositional deepfakes and reflect about cautions and potential mitigations to defend against them.

Learning Clinical Concepts for Predicting Risk of Progression to Severe COVID-19

With COVID-19 now pervasive, identification of high-risk individuals is crucial. Using data from a major healthcare provider in Southwestern Pennsylvania, we develop survival models predicting severe COVID-19 progression. In this endeavor, we face a tradeoff between more accurate models relying on many features and less accurate models relying on a few features aligned with clinician intuition. Complicating matters, many EHR features tend to be under-coded, degrading the accuracy of smaller models. In this study, we develop two sets of high-performance risk scores: (i) an unconstrained model built from all available features; and (ii) a pipeline that learns a small set of clinical concepts before training a risk predictor. Learned concepts boost performance over the corresponding features (C-index 0.858 vs. 0.844) and demonstrate improvements over (i) when evaluated out-of-sample (subsequent time periods). Our models outperform previous works (C-index 0.844-0.872 vs. 0.598-0.810).