NPRL: Nightly Profile Representation Learning for Early Sepsis Onset Prediction in ICU Trauma Patients

Sepsis is a syndrome that develops in response to the presence of infection. It is characterized by severe organ dysfunction and is one of the leading causes of mortality in Intensive Care Units (ICUs) worldwide. These complications can be reduced through early application of antibiotics, hence the ability to anticipate the onset of sepsis early is crucial to the survival and well-being of patients. Current machine learning algorithms deployed inside medical infrastructures have demonstrated poor performance and are insufficient for anticipating sepsis onset early. In recent years, deep learning methodologies have been proposed to predict sepsis, but some fail to capture the time of onset (e.g., classifying patients' entire visits as developing sepsis or not) and others are unrealistic to be deployed into medical facilities (e.g., creating training instances using a fixed time to onset where the time of onset needs to be known apriori). Therefore, in this paper, we first propose a novel but realistic prediction framework that predicts each morning whether sepsis onset will occur within the next 24 hours using data collected at night, when patient-provider ratios are higher due to cross-coverage resulting in limited observation to each patient. However, as we increase the prediction rate into daily, the number of negative instances will increase while that of positive ones remain the same. Thereafter, we have a severe class imbalance problem, making a machine learning model hard to capture rare sepsis cases. To address this problem, we propose to do nightly profile representation learning (NPRL) for each patient. We prove that NPRL can theoretically alleviate the rare event problem. Our empirical study using data from a level-1 trauma center further demonstrates the effectiveness of our proposal.

Contrastive Learning for Sleep Staging based on Inter Subject Correlation

In recent years, multitudes of researches have applied deep learning to automatic sleep stage classification. Whereas actually, these works have paid less attention to the issue of cross-subject in sleep staging. At the same time, emerging neuroscience theories on inter-subject correlations can provide new insights for cross-subject analysis. This paper presents the MViTime model that have been used in sleep staging study. And we implement the inter-subject correlation theory through contrastive learning, providing a feasible solution to address the cross-subject problem in sleep stage classification. Finally, experimental results and conclusions are presented, demonstrating that the developed method has achieved state-of-the-art performance on sleep staging. The results of the ablation experiment also demonstrate the effectiveness of the cross-subject approach based on contrastive learning.

Blockchain Large Language Models

This paper presents a dynamic, real-time approach to detecting anomalous blockchain transactions. The proposed tool, TXRANK, generates tracing representations of blockchain activity and trains from scratch a large language model to act as a real-time Intrusion Detection System. Unlike traditional methods, TXRANK is designed to offer an unrestricted search space and does not rely on predefined rules or patterns, enabling it to detect a broader range of anomalies. We demonstrate the effectiveness of TXRANK through its use as an anomaly detection tool for Ethereum transactions. In our experiments, it effectively identifies abnormal transactions among a dataset of 68M transactions and has a batched throughput of 2284 transactions per second on average. Our results show that, TXRANK identifies abnormal transactions by ranking 49 out of 124 attacks among the top-3 most abnormal transactions interacting with their victim contracts. This work makes contributions to the field of blockchain transaction analysis by introducing a custom data encoding compatible with the transformer architecture, a domain-specific tokenization technique, and a tree encoding method specifically crafted for the Ethereum Virtual Machine (EVM) trace representation.

Patch Diffusion: Faster and More Data-Efficient Training of Diffusion Models

Diffusion models are powerful, but they require a lot of time and data to train. We propose Patch Diffusion, a generic patch-wise training framework, to significantly reduce the training time costs while improving data efficiency, which thus helps democratize diffusion model training to broader users. At the core of our innovations is a new conditional score function at the patch level, where the patch location in the original image is included as additional coordinate channels, while the patch size is randomized and diversified throughout training to encode the cross-region dependency at multiple scales. Sampling with our method is as easy as in the original diffusion model. Through Patch Diffusion, we could achieve $\mathbf{\ge 2\times}$ faster training, while maintaining comparable or better generation quality. Patch Diffusion meanwhile improves the performance of diffusion models trained on relatively small datasets, $e.g.$, as few as 5,000 images to train from scratch. We achieve state-of-the-art FID scores 1.77 on CelebA-64$\times$64 and 1.93 on AFHQv2-Wild-64$\times$64. We will share our code and pre-trained models soon.

Adaptive Path-Memory Network for Temporal Knowledge Graph Reasoning

Temporal knowledge graph (TKG) reasoning aims to predict the future missing facts based on historical information and has gained increasing research interest recently. Lots of works have been made to model the historical structural and temporal characteristics for the reasoning task. Most existing works model the graph structure mainly depending on entity representation. However, the magnitude of TKG entities in real-world scenarios is considerable, and an increasing number of new entities will arise as time goes on. Therefore, we propose a novel architecture modeling with relation feature of TKG, namely aDAptivE path-MemOry Network (DaeMon), which adaptively models the temporal path information between query subject and each object candidate across history time. It models the historical information without depending on entity representation. Specifically, DaeMon uses path memory to record the temporal path information derived from path aggregation unit across timeline considering the memory passing strategy between adjacent timestamps. Extensive experiments conducted on four real-world TKG datasets demonstrate that our proposed model obtains substantial performance improvement and outperforms the state-of-the-art up to 4.8% absolute in MRR.

Physics-Informed Representation Learning for Emergent Organization in Complex Dynamical Systems

Nonlinearly interacting system components often introduce instabilities that generate phenomena with new properties and at different space-time scales than the components. This is known as spontaneous self-organization and is ubiquitous in systems far from thermodynamic equilibrium. We introduce a theoretically-grounded framework for emergent organization that, via data-driven algorithms, is constructive in practice. Its building blocks are spacetime lightcones that capture how information propagates across a system through local interactions. We show that predictive equivalence classes of lightcones, local causal states, capture organized behaviors and coherent structures in complex spatiotemporal systems. Using our unsupervised physics-informed machine learning algorithm and a high-performance computing implementation, we demonstrate the applicability of the local causal states for real-world domain science problems. We show that the local causal states capture vortices and their power-law decay behavior in two-dimensional turbulence. We then show that known (hurricanes and atmospheric rivers) and novel extreme weather events can be identified on a pixel-level basis and tracked through time in high-resolution climate data.

Causal Graph Discovery from Self and Mutually Exciting Time Series

We present a generalized linear structural causal model, coupled with a novel data-adaptive linear regularization, to recover causal directed acyclic graphs (DAGs) from time series. By leveraging a recently developed stochastic monotone Variational Inequality (VI) formulation, we cast the causal discovery problem as a general convex optimization. Furthermore, we develop a non-asymptotic recovery guarantee and quantifiable uncertainty by solving a linear program to establish confidence intervals for a wide range of non-linear monotone link functions. We validate our theoretical results and show the competitive performance of our method via extensive numerical experiments. Most importantly, we demonstrate the effectiveness of our approach in recovering highly interpretable causal DAGs over Sepsis Associated Derangements (SADs) while achieving comparable prediction performance to powerful ``black-box'' models such as XGBoost. Thus, the future adoption of our proposed method to conduct continuous surveillance of high-risk patients by clinicians is much more likely.

Identifying Appropriate Intellectual Property Protection Mechanisms for Machine Learning Models: A Systematization of Watermarking, Fingerprinting, Model Access, and Attacks

The commercial use of Machine Learning (ML) is spreading; at the same time, ML models are becoming more complex and more expensive to train, which makes Intellectual Property Protection (IPP) of trained models a pressing issue. Unlike other domains that can build on a solid understanding of the threats, attacks and defenses available to protect their IP, the ML-related research in this regard is still very fragmented. This is also due to a missing unified view as well as a common taxonomy of these aspects. In this paper, we systematize our findings on IPP in ML, while focusing on threats and attacks identified and defenses proposed at the time of writing. We develop a comprehensive threat model for IP in ML, categorizing attacks and defenses within a unified and consolidated taxonomy, thus bridging research from both the ML and security communities.

Gradient-Descent Based Optimization of Multi-Tone Sinusoidal Frequency Modulated Waveforms

This paper describes a gradient-descent based optimization algorithm for synthesizing Multi-Tone Sinusoidal Frequency Modulated (MTSFM) waveforms with low Auto-Correlation Function (ACF) sidelobes in a specified region of time delays while preserving the ACF mainlobe width. The algorithm optimizes the Generalized Integrated Sidelobe Level (GISL) which controls the mainlobe and sidelobe structure of the waveform's ACF. This optimization is performed subject to nonlinear constraints on the waveform's RMS bandwidth which directly controls the ACF mainlobe width. Since almost all of the operations of the algorithm utilize the Fast Fourier Transform (FFT), it is substantially more computationally efficient than previous methods that synthesized MTSFM waveforms with low ACF sidelobes. The computational efficiency of this new algorithm facilitates the design of larger dimensional and correspondingly larger time-bandwidth product MTSFM waveform designs. The algorithm is demonstrated through several illustrative MTSFM design examples.

Curating corpora with classifiers: A case study of clean energy sentiment online

Well curated, large-scale corpora of social media posts containing broad public opinion offer an alternative data source to complement traditional surveys. While surveys are effective at collecting representative samples and are capable of achieving high accuracy, they can be both expensive to run and lag public opinion by days or weeks. Both of these drawbacks could be overcome with a real-time, high volume data stream and fast analysis pipeline. A central challenge in orchestrating such a data pipeline is devising an effective method for rapidly selecting the best corpus of relevant documents for analysis. Querying with keywords alone often includes irrelevant documents that are not easily disambiguated with bag-of-words natural language processing methods. Here, we explore methods of corpus curation to filter irrelevant tweets using pre-trained transformer-based models, fine-tuned for our binary classification task on hand-labeled tweets. We are able to achieve F1 scores of up to 0.95. The low cost and high performance of fine-tuning such a model suggests that our approach could be of broad benefit as a pre-processing step for social media datasets with uncertain corpus boundaries.