Denoising Low-dose Images Using Deep Learning of Time Series Images

Digital image devices have been widely applied in many fields, including scientific imaging, recognition of individuals, and remote sensing. As the application of these imaging technologies to autonomous driving and measurement, image noise generated when observation cannot be performed with a sufficient dose has become a major problem. Machine learning denoise technology is expected to be the solver of this problem, but there are the following problems. Here we report, artifacts generated by machine learning denoise in ultra-low dose observation using an in-situ observation video of an electron microscope as an example. And as a method to solve this problem, we propose a method to decompose a time series image into a 2D image of the spatial axis and time to perform machine learning denoise. Our method opens new avenues accurate and stable reconstruction of continuous high-resolution images from low-dose imaging in science, industry, and life.

MING-MOE: Enhancing Medical Multi-Task Learning in Large Language Models with Sparse Mixture of Low-Rank Adapter Experts

Large language models like ChatGPT have shown substantial progress in natural language understanding and generation, proving valuable across various disciplines, including the medical field. Despite advancements, challenges persist due to the complexity and diversity inherent in medical tasks which often require multi-task learning capabilities. Previous approaches, although beneficial, fall short in real-world applications because they necessitate task-specific annotations at inference time, limiting broader generalization. This paper introduces MING-MOE, a novel Mixture-of-Expert~(MOE)-based medical large language model designed to manage diverse and complex medical tasks without requiring task-specific annotations, thus enhancing its usability across extensive datasets. MING-MOE employs a Mixture of Low-Rank Adaptation (MoLoRA) technique, allowing for efficient parameter usage by maintaining base model parameters static while adapting through a minimal set of trainable parameters. We demonstrate that MING-MOE achieves state-of-the-art (SOTA) performance on over 20 medical tasks, illustrating a significant improvement over existing models. This approach not only extends the capabilities of medical language models but also improves inference efficiency.

Adapting to Covariate Shift in Real-time by Encoding Trees with Motion Equations

Input distribution shift presents a significant problem in many real-world systems. Here we present Xenovert, an adaptive algorithm that can dynamically adapt to changes in input distribution. It is a perfect binary tree that adaptively divides a continuous input space into several intervals of uniform density while receiving a continuous stream of input. This process indirectly maps the source distribution to the shifted target distribution, preserving the data's relationship with the downstream decoder/operation, even after the shift occurs. In this paper, we demonstrated how a neural network integrated with Xenovert achieved better results in 4 out of 5 shifted datasets, saving the hurdle of retraining a machine learning model. We anticipate that Xenovert can be applied to many more applications that require adaptation to unforeseen input distribution shifts, even when the distribution shift is drastic.

Apprentice Tutor Builder: A Platform For Users to Create and Personalize Intelligent Tutors

Intelligent tutoring systems (ITS) are effective for improving students' learning outcomes. However, their development is often complex, time-consuming, and requires specialized programming and tutor design knowledge, thus hindering their widespread application and personalization. We present the Apprentice Tutor Builder (ATB) , a platform that simplifies tutor creation and personalization. Instructors can utilize ATB's drag-and-drop tool to build tutor interfaces. Instructors can then interactively train the tutors' underlying AI agent to produce expert models that can solve problems. Training is achieved via using multiple interaction modalities including demonstrations, feedback, and user labels. We conducted a user study with 14 instructors to evaluate the effectiveness of ATB's design with end users. We found that users enjoyed the flexibility of the interface builder and ease and speed of agent teaching, but often desired additional time-saving features. With these insights, we identified a set of design recommendations for our platform and others that utilize interactive AI agents for tutor creation and customization.

Context-aware Video Anomaly Detection in Long-Term Datasets

Video anomaly detection research is generally evaluated on short, isolated benchmark videos only a few minutes long. However, in real-world environments, security cameras observe the same scene for months or years at a time, and the notion of anomalous behavior critically depends on context, such as the time of day, day of week, or schedule of events. Here, we propose a context-aware video anomaly detection algorithm, Trinity, specifically targeted to these scenarios. Trinity is especially well-suited to crowded scenes in which individuals cannot be easily tracked, and anomalies are due to speed, direction, or absence of group motion. Trinity is a contrastive learning framework that aims to learn alignments between context, appearance, and motion, and uses alignment quality to classify videos as normal or anomalous. We evaluate our algorithm on both conventional benchmarks and a public webcam-based dataset we collected that spans more than three months of activity.

Global Contrastive Training for Multimodal Electronic Health Records with Language Supervision

Modern electronic health records (EHRs) hold immense promise in tracking personalized patient health trajectories through sequential deep learning, owing to their extensive breadth, scale, and temporal granularity. Nonetheless, how to effectively leverage multiple modalities from EHRs poses significant challenges, given its complex characteristics such as high dimensionality, multimodality, sparsity, varied recording frequencies, and temporal irregularities. To this end, this paper introduces a novel multimodal contrastive learning framework, specifically focusing on medical time series and clinical notes. To tackle the challenge of sparsity and irregular time intervals in medical time series, the framework integrates temporal cross-attention transformers with a dynamic embedding and tokenization scheme for learning multimodal feature representations. To harness the interconnected relationships between medical time series and clinical notes, the framework equips a global contrastive loss, aligning a patient's multimodal feature representations with the corresponding discharge summaries. Since discharge summaries uniquely pertain to individual patients and represent a holistic view of the patient's hospital stay, machine learning models are led to learn discriminative multimodal features via global contrasting. Extensive experiments with a real-world EHR dataset demonstrated that our framework outperformed state-of-the-art approaches on the exemplar task of predicting the occurrence of nine postoperative complications for more than 120,000 major inpatient surgeries using multimodal data from UF health system split among three hospitals (UF Health Gainesville, UF Health Jacksonville, and UF Health Jacksonville-North).

Rethinking Out-of-Distribution Detection for Reinforcement Learning: Advancing Methods for Evaluation and Detection

While reinforcement learning (RL) algorithms have been successfully applied across numerous sequential decision-making problems, their generalization to unforeseen testing environments remains a significant concern. In this paper, we study the problem of out-of-distribution (OOD) detection in RL, which focuses on identifying situations at test time that RL agents have not encountered in their training environments. We first propose a clarification of terminology for OOD detection in RL, which aligns it with the literature from other machine learning domains. We then present new benchmark scenarios for OOD detection, which introduce anomalies with temporal autocorrelation into different components of the agent-environment loop. We argue that such scenarios have been understudied in the current literature, despite their relevance to real-world situations. Confirming our theoretical predictions, our experimental results suggest that state-of-the-art OOD detectors are not able to identify such anomalies. To address this problem, we propose a novel method for OOD detection, which we call DEXTER (Detection via Extraction of Time Series Representations). By treating environment observations as time series data, DEXTER extracts salient time series features, and then leverages an ensemble of isolation forest algorithms to detect anomalies. We find that DEXTER can reliably identify anomalies across benchmark scenarios, exhibiting superior performance compared to both state-of-the-art OOD detectors and high-dimensional changepoint detectors adopted from statistics.

PraFFL: A Preference-Aware Scheme in Fair Federated Learning

Fairness in federated learning has emerged as a critical concern, aiming to develop an unbiased model for any special group (e.g., male or female) of sensitive features. However, there is a trade-off between model performance and fairness, i.e., improving fairness will decrease model performance. Existing approaches have characterized such a trade-off by introducing hyperparameters to quantify client's preferences for fairness and model performance. Nevertheless, these methods are limited to scenarios where each client has only a single pre-defined preference. In practical systems, each client may simultaneously have multiple preferences for the model performance and fairness. The key challenge is to design a method that allows the model to adapt to diverse preferences of each client in real time. To this end, we propose a Preference-aware scheme in Fair Federated Learning paradigm (called PraFFL). PraFFL can adaptively adjust the model based on each client's preferences to meet their needs. We theoretically prove that PraFFL can provide the optimal model for client's arbitrary preferences. Experimental results show that our proposed PraFFL outperforms five existing fair federated learning algorithms in terms of the model's capability in adapting to clients' different preferences.

Active Learning for Control-Oriented Identification of Nonlinear Systems

Model-based reinforcement learning is an effective approach for controlling an unknown system. It is based on a longstanding pipeline familiar to the control community in which one performs experiments on the environment to collect a dataset, uses the resulting dataset to identify a model of the system, and finally performs control synthesis using the identified model. As interacting with the system may be costly and time consuming, targeted exploration is crucial for developing an effective control-oriented model with minimal experimentation. Motivated by this challenge, recent work has begun to study finite sample data requirements and sample efficient algorithms for the problem of optimal exploration in model-based reinforcement learning. However, existing theory and algorithms are limited to model classes which are linear in the parameters. Our work instead focuses on models with nonlinear parameter dependencies, and presents the first finite sample analysis of an active learning algorithm suitable for a general class of nonlinear dynamics. In certain settings, the excess control cost of our algorithm achieves the optimal rate, up to logarithmic factors. We validate our approach in simulation, showcasing the advantage of active, control-oriented exploration for controlling nonlinear systems.

AETTA: Label-Free Accuracy Estimation for Test-Time Adaptation

Test-time adaptation (TTA) has emerged as a viable solution to adapt pre-trained models to domain shifts using unlabeled test data. However, TTA faces challenges of adaptation failures due to its reliance on blind adaptation to unknown test samples in dynamic scenarios. Traditional methods for out-of-distribution performance estimation are limited by unrealistic assumptions in the TTA context, such as requiring labeled data or re-training models. To address this issue, we propose AETTA, a label-free accuracy estimation algorithm for TTA. We propose the prediction disagreement as the accuracy estimate, calculated by comparing the target model prediction with dropout inferences. We then improve the prediction disagreement to extend the applicability of AETTA under adaptation failures. Our extensive evaluation with four baselines and six TTA methods demonstrates that AETTA shows an average of 19.8%p more accurate estimation compared with the baselines. We further demonstrate the effectiveness of accuracy estimation with a model recovery case study, showcasing the practicality of our model recovery based on accuracy estimation. The source code is available at https://github.com/taeckyung/AETTA.