Digital pathology enables automatic analysis of histopathological sections using artificial intelligence (AI). Automatic evaluation could improve diagnostic efficiency and help find associations between morphological features and clinical outcome. For development of such prediction models, identifying invasive epithelial cells, and separating these from benign epithelial cells and in situ lesions would be the first step. In this study, we aimed to develop an AI model for segmentation of epithelial cells in sections from breast cancer. We generated epithelial ground truth masks by restaining hematoxylin and eosin (HE) sections with cytokeratin (CK) AE1/AE3, and by pathologists' annotations. HE/CK image pairs were used to train a convolutional neural network, and data augmentation was used to make the model more robust. Tissue microarrays (TMAs) from 839 patients, and whole slide images from two patients were used for training and evaluation of the models. The sections were derived from four cohorts of breast cancer patients. TMAs from 21 patients from a fifth cohort was used as a second test set. In quantitative evaluation, a mean Dice score of 0.70, 0.79, and 0.75 for invasive epithelial cells, benign epithelial cells, and in situ lesions, respectively, were achieved. In qualitative scoring (0-5) by pathologists, results were best for all epithelium and invasive epithelium, with scores of 4.7 and 4.4. Scores for benign epithelium and in situ lesions were 3.7 and 2.0. The proposed model segmented epithelial cells in HE stained breast cancer slides well, but further work is needed for accurate division between the classes. Immunohistochemistry, together with pathologists' annotations, enabled the creation of accurate ground truths. The model is made freely available in FastPathology and the code is available at https://github.com/AICAN-Research/breast-epithelium-segmentation
The revolution of artificial intelligence content generation has been rapidly accelerated with the booming text-to-image (T2I) diffusion models. Within just two years of development, it was unprecedentedly of high-quality, diversity, and creativity that the state-of-the-art models could generate. However, a prevalent limitation persists in the effective communication with these popular T2I models, such as Stable Diffusion, using natural language descriptions. This typically makes an engaging image hard to obtain without expertise in prompt engineering with complex word compositions, magic tags, and annotations. Inspired by the recently released DALLE3 - a T2I model directly built-in ChatGPT that talks human language, we revisit the existing T2I systems endeavoring to align human intent and introduce a new task - interactive text to image (iT2I), where people can interact with LLM for interleaved high-quality image generation/edit/refinement and question answering with stronger images and text correspondences using natural language. In addressing the iT2I problem, we present a simple approach that augments LLMs for iT2I with prompting techniques and off-the-shelf T2I models. We evaluate our approach for iT2I in a variety of common-used scenarios under different LLMs, e.g., ChatGPT, LLAMA, Baichuan, and InternLM. We demonstrate that our approach could be a convenient and low-cost way to introduce the iT2I ability for any existing LLMs and any text-to-image models without any training while bringing little degradation on LLMs' inherent capabilities in, e.g., question answering and code generation. We hope this work could draw broader attention and provide inspiration for boosting user experience in human-machine interactions alongside the image quality of the next-generation T2I systems.
Generative Adversarial Networks (GANs) have risen to prominence in the field of deep learning, facilitating the generation of realistic data from random noise. The effectiveness of GANs often depends on the quality of feature extraction, a critical aspect of their architecture. This paper introduces L-WaveBlock, a novel and robust feature extractor that leverages the capabilities of the Discrete Wavelet Transform (DWT) with deep learning methodologies. L-WaveBlock is catered to quicken the convergence of GAN generators while simultaneously enhancing their performance. The paper demonstrates the remarkable utility of L-WaveBlock across three datasets, a road satellite imagery dataset, the CelebA dataset and the GoPro dataset, showcasing its ability to ease feature extraction and make it more efficient. By utilizing DWT, L-WaveBlock efficiently captures the intricate details of both structural and textural details, and further partitions feature maps into orthogonal subbands across multiple scales while preserving essential information at the same time. Not only does it lead to faster convergence, but also gives competent results on every dataset by employing the L-WaveBlock. The proposed method achieves an Inception Score of 3.6959 and a Structural Similarity Index of 0.4261 on the maps dataset, a Peak Signal-to-Noise Ratio of 29.05 and a Structural Similarity Index of 0.874 on the CelebA dataset. The proposed method performs competently to the state-of-the-art for the image denoising dataset, albeit not better, but still leads to faster convergence than conventional methods. With this, L-WaveBlock emerges as a robust and efficient tool for enhancing GAN-based image generation, demonstrating superior convergence speed and competitive performance across multiple datasets for image resolution, image generation and image denoising.
Natural scene analysis and remote sensing imagery offer immense potential for advancements in large-scale language-guided context-aware data utilization. This potential is particularly significant for enhancing performance in downstream tasks such as object detection and segmentation with designed language prompting. In light of this, we introduce the CPSeg, Chain-of-Thought Language Prompting for Finer-grained Semantic Segmentation), an innovative framework designed to augment image segmentation performance by integrating a novel "Chain-of-Thought" process that harnesses textual information associated with images. This groundbreaking approach has been applied to a flood disaster scenario. CPSeg encodes prompt texts derived from various sentences to formulate a coherent chain-of-thought. We propose a new vision-language dataset, FloodPrompt, which includes images, semantic masks, and corresponding text information. This not only strengthens the semantic understanding of the scenario but also aids in the key task of semantic segmentation through an interplay of pixel and text matching maps. Our qualitative and quantitative analyses validate the effectiveness of CPSeg.
In the context of the long-tail scenario, models exhibit a strong demand for high-quality data. Data-centric approaches aim to enhance both the quantity and quality of data to improve model performance. Among these approaches, information augmentation has been progressively introduced as a crucial category. It achieves a balance in model performance by augmenting the richness and quantity of samples in the tail classes. However, there is currently a lack of research into the underlying mechanisms explaining the effectiveness of information augmentation methods. Consequently, the utilization of information augmentation in long-tail recognition tasks relies heavily on empirical and intricate fine-tuning. This work makes two primary contributions. Firstly, we approach the problem from the perspectives of feature diversity and distribution shift, introducing the concept of Feature Diversity Gain (FDG) to elucidate why information augmentation is effective. We find that the performance of information augmentation can be explained by FDG, and its performance peaks when FDG achieves an appropriate balance. Experimental results demonstrate that by using FDG to select augmented data, we can further enhance model performance without the need for any modifications to the model's architecture. Thus, data-centric approaches hold significant potential in the field of long-tail recognition, beyond the development of new model structures. Furthermore, we systematically introduce the core components and fundamental tasks of a data-centric long-tail learning framework for the first time. These core components guide the implementation and deployment of the system, while the corresponding fundamental tasks refine and expand the research area.
The rapid evolution of deep learning has significantly advanced the field of medical image analysis. However, despite these achievements, the further enhancement of deep learning models for medical image analysis faces a significant challenge due to the scarcity of large, well-annotated datasets. To address this issue, recent years have witnessed a growing emphasis on the development of data-efficient deep learning methods. This paper conducts a thorough review of data-efficient deep learning methods for medical image analysis. To this end, we categorize these methods based on the level of supervision they rely on, encompassing categories such as no supervision, inexact supervision, incomplete supervision, inaccurate supervision, and only limited supervision. We further divide these categories into finer subcategories. For example, we categorize inexact supervision into multiple instance learning and learning with weak annotations. Similarly, we categorize incomplete supervision into semi-supervised learning, active learning, and domain-adaptive learning and so on. Furthermore, we systematically summarize commonly used datasets for data efficient deep learning in medical image analysis and investigate future research directions to conclude this survey.
Underwater docking is critical to enable the persistent operation of Autonomous Underwater Vehicles (AUVs). For this, the AUV must be capable of detecting and localizing the docking station, which is complex due to the highly dynamic undersea environment. Image-based solutions offer a high acquisition rate and versatile alternative to adapt to this environment; however, the underwater environment presents challenges such as low visibility, high turbidity, and distortion. In addition to this, field experiments to validate underwater docking capabilities can be costly and dangerous due to the specialized equipment and safety considerations required to conduct the experiments. This work compares different deep-learning architectures to perform underwater docking detection and classification. The architecture with the best performance is then compressed using knowledge distillation under the teacher-student paradigm to reduce the network's memory footprint, allowing real-time implementation. To reduce the simulation-to-reality gap, a Generative Adversarial Network (GAN) is used to do image-to-image translation, converting the Gazebo simulation image into a realistic underwater-looking image. The obtained image is then processed using an underwater image formation model to simulate image attenuation over distance under different water types. The proposed method is finally evaluated according to the AUV docking success rate and compared with classical vision methods. The simulation results show an improvement of 20% in the high turbidity scenarios regardless of the underwater currents. Furthermore, we show the performance of the proposed approach by showing experimental results on the off-the-shelf AUV Iver3.
Medical image segmentation plays a crucial role in advancing healthcare systems for disease diagnosis and treatment planning. The u-shaped architecture, popularly known as U-Net, has proven highly successful for various medical image segmentation tasks. However, U-Net's convolution-based operations inherently limit its ability to model long-range dependencies effectively. To address these limitations, researchers have turned to Transformers, renowned for their global self-attention mechanisms, as alternative architectures. One popular network is our previous TransUNet, which leverages Transformers' self-attention to complement U-Net's localized information with the global context. In this paper, we extend the 2D TransUNet architecture to a 3D network by building upon the state-of-the-art nnU-Net architecture, and fully exploring Transformers' potential in both the encoder and decoder design. We introduce two key components: 1) A Transformer encoder that tokenizes image patches from a convolution neural network (CNN) feature map, enabling the extraction of global contexts, and 2) A Transformer decoder that adaptively refines candidate regions by utilizing cross-attention between candidate proposals and U-Net features. Our investigations reveal that different medical tasks benefit from distinct architectural designs. The Transformer encoder excels in multi-organ segmentation, where the relationship among organs is crucial. On the other hand, the Transformer decoder proves more beneficial for dealing with small and challenging segmented targets such as tumor segmentation. Extensive experiments showcase the significant potential of integrating a Transformer-based encoder and decoder into the u-shaped medical image segmentation architecture. TransUNet outperforms competitors in various medical applications.
Medical image segmentation has immense clinical applicability but remains a challenge despite advancements in deep learning. The Segment Anything Model (SAM) exhibits potential in this field, yet the requirement for expertise intervention and the domain gap between natural and medical images poses significant obstacles. This paper introduces a novel training-free evidential prompt generation method named EviPrompt to overcome these issues. The proposed method, built on the inherent similarities within medical images, requires only a single reference image-annotation pair, making it a training-free solution that significantly reduces the need for extensive labeling and computational resources. First, to automatically generate prompts for SAM in medical images, we introduce an evidential method based on uncertainty estimation without the interaction of clinical experts. Then, we incorporate the human prior into the prompts, which is vital for alleviating the domain gap between natural and medical images and enhancing the applicability and usefulness of SAM in medical scenarios. EviPrompt represents an efficient and robust approach to medical image segmentation, with evaluations across a broad range of tasks and modalities confirming its efficacy.
Textural Inversion, a prompt learning method, learns a singular embedding for a new "word" to represent image style and appearance, allowing it to be integrated into natural language sentences to generate novel synthesised images. However, identifying and integrating multiple object-level concepts within one scene poses significant challenges even when embeddings for individual concepts are attainable. This is further confirmed by our empirical tests. To address this challenge, we introduce a framework for Multi-Concept Prompt Learning (MCPL), where multiple new "words" are simultaneously learned from a single sentence-image pair. To enhance the accuracy of word-concept correlation, we propose three regularisation techniques: Attention Masking (AttnMask) to concentrate learning on relevant areas; Prompts Contrastive Loss (PromptCL) to separate the embeddings of different concepts; and Bind adjective (Bind adj.) to associate new "words" with known words. We evaluate via image generation, editing, and attention visualisation with diverse images. Extensive quantitative comparisons demonstrate that our method can learn more semantically disentangled concepts with enhanced word-concept correlation. Additionally, we introduce a novel dataset and evaluation protocol tailored for this new task of learning object-level concepts.