Understanding the morphological changes of primary neuronal cells induced by chemical compounds is essential for drug discovery. Using the data from a single high-throughput imaging assay, a classification model for predicting the biological activity of candidate compounds was introduced. The image recognition model which is based on deep convolutional neural network (CNN) architecture with residual connections achieved accuracy of 99.6$\%$ on a binary classification task of distinguishing untreated and treated rodent primary neuronal cells with Amyloid-$\beta_{(25-35)}$.
Recent works on domain adaptation exploit adversarial training to obtain domain-invariant feature representations from the joint learning of feature extractor and domain discriminator networks. However, domain adversarial methods render suboptimal performances since they attempt to match the distributions among the domains without considering the task at hand. We propose Drop to Adapt (DTA), which leverages adversarial dropout to learn strongly discriminative features by enforcing the cluster assumption. Accordingly, we design objective functions to support robust domain adaptation. We demonstrate efficacy of the proposed method on various experiments and achieve consistent improvements in both image classification and semantic segmentation tasks. Our source code is available at https://github.com/postBG/DTA.pytorch.
The recent years have witnessed the great potential of deep learning for video compression. In this paper, we propose the Hierarchical Learned Video Compression (HLVC) approach with three hierarchical quality layers and recurrent enhancement. To be specific, the frames in the first layer are compressed by image compression method with the highest quality. Using them as references, we propose the Bi-Directional Deep Compression (BDDC) network to compress the second layer with relatively high quality. Then, the third layer frames are compressed with the lowest quality, by the proposed Single Motion Deep Compression (SMDC) network, which adopts a single motion map to estimate the motions of multiple frames, thus saving the bit-rate for motion information. In our deep decoder, we develop the Weighted Recurrent Quality Enhancement (WRQE) network with the inputs of both compressed frames and bit stream. In the recurrent cell of WRQE, the memory and update signal are weighted by quality features to reasonably leverage multi-frame information for enhancement. In our HLVC approach, the hierarchical quality benefits the coding efficiency, since the high quality information facilitates the compression and enhancement of low quality frames at encoder and decoder sides, respectively. Finally, the experiments validate that our HLVC approach advances the state-of-the-art deep video compression methods, and outperforms x265 low delay P very fast mode in terms of both PSNR and MS-SSIM. The project page is at https://github.com/RenYang-home/HLVC.
Incorporating touch as a sensing modality for robots can enable finer and more robust manipulation skills. Existing tactile sensors are either flat, have small sensitive fields or only provide low-resolution signals. In this paper, we introduce OmniTact, a multi-directional high-resolution tactile sensor. OmniTact is designed to be used as a fingertip for robotic manipulation with robotic hands, and uses multiple micro-cameras to detect multi-directional deformations of a gel-based skin. This provides a rich signal from which a variety of different contact state variables can be inferred using modern image processing and computer vision methods. We evaluate the capabilities of OmniTact on a challenging robotic control task that requires inserting an electrical connector into an outlet, as well as a state estimation problem that is representative of those typically encountered in dexterous robotic manipulation, where the goal is to infer the angle of contact of a curved finger pressing against an object. Both tasks are performed using only touch sensing and deep convolutional neural networks to process images from the sensor's cameras. We compare with a state-of-the-art tactile sensor that is only sensitive on one side, as well as a state-of-the-art multi-directional tactile sensor, and find that OmniTact's combination of high-resolution and multi-directional sensing is crucial for reliably inserting the electrical connector and allows for higher accuracy in the state estimation task. Videos and supplementary material can be found at https://sites.google.com/berkeley.edu/omnitact
We investigate the compression of deep neural networks by quantizing their weights and activations into multiple binary bases, known as multi-bit networks (MBNs), which accelerates the inference and reduces the storage for deployment on low-resource mobile and embedded platforms. We propose Adaptive Loss-aware Quantization (ALQ), a new MBN quantization pipeline that is able to achieve an average bitwidth below one bit without notable loss in inference accuracy. Unlike previous MBN quantization solutions that train a quantizer by minimizing the error to reconstruct full precision weights, ALQ directly minimizes the quantization-induced error on the loss function involving neither gradient approximation nor full precision calculations. ALQ also exploits strategies including adaptive bitwidth, smooth bitwidth reduction, and iterative trained quantization to allow a smaller network size without loss in accuracy. Experiment results on popular image datasets show that ALQ outperforms state-of-the-art compressed networks in terms of both storage and accuracy.
Generative models based on generative adversarial networks (GANs) and variational autoencoders (VAEs) have been widely studied in the fields of image generation, speech generation, and drug discovery, but, only a few studies have focused on the generation of inorganic materials. Such studies use the crystal structures of materials, but material researchers rarely store this information. Thus, we generate chemical compositions without using crystal information. We use a conditional VAE (CondVAE) and a conditional GAN (CondGAN) and show that CondGAN using the bag-of-atom representation with physical descriptors generates better compositions than other generative models. Also, we evaluate the effectiveness of the Metropolis-Hastings-based atomic valency modification and the extrapolation performance, which is important to material discovery.
Meta-learning is a promising strategy for learning to efficiently learn within new tasks, using data gathered from a distribution of tasks. However, the meta-learning literature thus far has focused on the task segmented setting, where at train-time, offline data is assumed to be split according to the underlying task, and at test-time, the algorithms are optimized to learn in a single task. In this work, we enable the application of generic meta-learning algorithms to settings where this task segmentation is unavailable, such as continual online learning with a time-varying task. We present meta-learning via online changepoint analysis (MOCA), an approach which augments a meta-learning algorithm with a differentiable Bayesian changepoint detection scheme. The framework allows both training and testing directly on time series data without segmenting it into discrete tasks. We demonstrate the utility of this approach on a nonlinear meta-regression benchmark as well as two meta-image-classification benchmarks.
We present a new latent model of natural images that can be learned on large-scale datasets. The learning process provides a latent embedding for every image in the training dataset, as well as a deep convolutional network that maps the latent space to the image space. After training, the new model provides a strong and universal image prior for a variety of image restoration tasks such as large-hole inpainting, superresolution, and colorization. To model high-resolution natural images, our approach uses latent spaces of very high dimensionality (one to two orders of magnitude higher than previous latent image models). To tackle this high dimensionality, we use latent spaces with a special manifold structure (convolutional manifolds) parameterized by a ConvNet of a certain architecture. In the experiments, we compare the learned latent models with latent models learned by autoencoders, advanced variants of generative adversarial networks, and a strong baseline system using simpler parameterization of the latent space. Our model outperforms the competing approaches over a range of restoration tasks.
Cardiac MR image segmentation is essential for the morphological and functional analysis of the heart. Inspired by how experienced clinicians assess the cardiac morphology and function across multiple standard views (i.e. long- and short-axis views), we propose a novel approach which learns anatomical shape priors across different 2D standard views and leverages these priors to segment the left ventricular (LV) myocardium from short-axis MR image stacks. The proposed segmentation method has the advantage of being a 2D network but at the same time incorporates spatial context from multiple, complementary views that span a 3D space. Our method achieves accurate and robust segmentation of the myocardium across different short-axis slices (from apex to base), outperforming baseline models (e.g. 2D U-Net, 3D U-Net) while achieving higher data efficiency. Compared to the 2D U-Net, the proposed method reduces the mean Hausdorff distance (mm) from 3.24 to 2.49 on the apical slices, from 2.34 to 2.09 on the middle slices and from 3.62 to 2.76 on the basal slices on the test set, when only 10% of the training data was used.
In many cases, neural network classifiers are likely to be exposed to input data that is outside of their training distribution data. Samples from outside the distribution may be classified as an existing class with high probability by softmax-based classifiers; such incorrect classifications affect the performance of the classifiers and the applications/systems that depend on them. Previous research aimed at distinguishing training distribution data from out-of-distribution data (OOD) has proposed detectors that are external to the classification method. We present Gaussian isolation machine (GIM), a novel hybrid (generative-discriminative) classifier aimed at solving the problem arising when OOD data is encountered. The GIM is based on a neural network and utilizes a new loss function that imposes a distribution on each of the trained classes in the neural network's output space, which can be approximated by a Gaussian. The proposed GIM's novelty lies in its discriminative performance and generative capabilities, a combination of characteristics not usually seen in a single classifier. The GIM achieves state-of-the-art classification results on image recognition and sentiment analysis benchmarking datasets and can also deal with OOD inputs. We also demonstrate the benefits of incorporating part of the GIM's loss function into standard neural networks as a regularization method.