Coronary Computed Tomography Angiography (CCTA) evaluation of chest-pain patients in an Emergency Department (ED) is considered appropriate. While a negative CCTA interpretation supports direct patient discharge from an ED, labor-intensive analyses are required, with accuracy in jeopardy from distractions. We describe the development of an Artificial Intelligence (AI) algorithm and workflow for assisting interpreting physicians in CCTA screening for the absence of coronary atherosclerosis. The two-phase approach consisted of (1) Phase 1 - focused on the development and preliminary testing of an algorithm for vessel-centerline extraction classification in a balanced study population (n = 500 with 50% disease prevalence) derived by retrospective random case selection; and (2) Phase 2 - concerned with simulated-clinical Trialing of the developed algorithm on a per-case basis in a more real-world study population (n = 100 with 28% disease prevalence) from an ED chest-pain series. This allowed pre-deployment evaluation of the AI-based CCTA screening application which provides a vessel-by-vessel graphic display of algorithm inference results integrated into a clinically capable viewer. Algorithm performance evaluation used Area Under the Receiver-Operating-Characteristic Curve (AUC-ROC); confusion matrices reflected ground-truth vs AI determinations. The vessel-based algorithm demonstrated strong performance with AUC-ROC = 0.96. In both Phase 1 and Phase 2, independent of disease prevalence differences, negative predictive values at the case level were very high at 95%. The rate of completion of the algorithm workflow process (96% with inference results in 55-80 seconds) in Phase 2 depended on adequate image quality. There is potential for this AI application to assist in CCTA interpretation to help extricate atherosclerosis from chest-pain presentations.
In recent years, deep learning methods have outperformed other methods in image recognition. This has fostered imagination of potential application of deep learning technology including safety relevant applications like the interpretation of medical images or autonomous driving. The passage from assistance of a human decision maker to ever more automated systems however increases the need to properly handle the failure modes of deep learning modules. In this contribution, we review a set of techniques for the self-monitoring of machine-learning algorithms based on uncertainty quantification. In particular, we apply this to the task of semantic segmentation, where the machine learning algorithm decomposes an image according to semantic categories. We discuss false positive and false negative error modes at instance-level and review techniques for the detection of such errors that have been recently proposed by the authors. We also give an outlook on future research directions.
Generating good quality and geometrically plausible synthetic images of humans with the ability to control appearance, pose and shape parameters, has become increasingly important for a variety of tasks ranging from photo editing, fashion virtual try-on, to special effects and image compression. In this paper, we propose HUSC, a HUman Synthesis and Scene Compositing framework for the realistic synthesis of humans with different appearance, in novel poses and scenes. Central to our formulation is 3d reasoning for both people and scenes, in order to produce realistic collages, by correctly modeling perspective effects and occlusion, by taking into account scene semantics and by adequately handling relative scales. Conceptually our framework consists of three components: (1) a human image synthesis model with controllable pose and appearance, based on a parametric representation, (2) a person insertion procedure that leverages the geometry and semantics of the 3d scene, and (3) an appearance compositing process to create a seamless blending between the colors of the scene and the generated human image, and avoid visual artifacts. The performance of our framework is supported by both qualitative and quantitative results, in particular state-of-the art synthesis scores for the DeepFashion dataset.
Scene recognition model based on the DNN and game theory with its applications in human-robot interaction is proposed in this paper. The use of deep learning methods in the field of image scene recognition is still in its infancy, but has become an important trend in the future. As the innovative idea of the paper, we propose the following novelties. (1) In this paper, the discrete displacement field is used to represent deformation. The registration problem is transformed into a problem of minimum energy in random field to finalize the image pre-processing task. (2) We select neighboring homogeneous sample features and the neighboring heterogeneous sample features for the extracted sample features to build a triple and modify the traditional neural network to propose the novel DNN for scene understanding. (3) The robot control is well combined to guide the robot vision for multiple tasks. The experiment is then conducted to validate the overall performance.
Most existing black-box optimization methods assume that all variables in the system being optimized have equal cost and can change freely at each iteration. However, in many real world systems, inputs are passed through a sequence of different operations or modules, making variables in earlier stages of processing more costly to update. Such structure imposes a cost on switching variables in early parts of a data processing pipeline. In this work, we propose a new algorithm for switch cost-aware optimization called Lazy Modular Bayesian Optimization (LaMBO). This method efficiently identifies the global optimum while minimizing cost through a passive change of variables in early modules. The method is theoretical grounded and achieves vanishing regret when augmented with switching cost. We apply LaMBO to multiple synthetic functions and a three-stage image segmentation pipeline used in a neuroscience application, where we obtain promising improvements over prevailing cost-aware Bayesian optimization algorithms. Our results demonstrate that LaMBO is an effective strategy for black-box optimization that is capable of minimizing switching costs in modular systems.
Despite the growing interest in continual learning, most of its contemporary works have been studied in a rather restricted setting where tasks are clearly distinguishable, and task boundaries are known during training. However, if our goal is to develop an algorithm that learns as humans do, this setting is far from realistic, and it is essential to develop a methodology that works in a task-free manner. Meanwhile, among several branches of continual learning, expansion-based methods have the advantage of eliminating catastrophic forgetting by allocating new resources to learn new data. In this work, we propose an expansion-based approach for task-free continual learning. Our model, named Continual Neural Dirichlet Process Mixture (CN-DPM), consists of a set of neural network experts that are in charge of a subset of the data. CN-DPM expands the number of experts in a principled way under the Bayesian nonparametric framework. With extensive experiments, we show that our model successfully performs task-free continual learning for both discriminative and generative tasks such as image classification and image generation.
Modern pendant drop tensiometry relies on numerical solution of the Young-Laplace equation and allow to determine the surface tension from a single picture of a pendant drop with high precision. Most of these techniques solve the Young-Laplace equation many times over to find the material parameters that provide a fit to a supplied image of a real droplet. Here we introduce a machine learning approach to solve this problem in a computationally more efficient way. We train a deep neural network to determine the surface tension of a given droplet shape using a large training set of numerically generated droplet shapes. We show that the deep learning approach is superior to the current state of the art shape fitting approach in speed and precision, in particular if shapes in the training set reflect the sensitivity of the droplet shape with respect to surface tension. In order to derive such an optimized training set we clarify the role of the Worthington number as quality indicator in conventional shape fitting and in the machine learning approach. Our approach demonstrates the capabilities of deep neural networks in the material parameter determination from rheological deformation experiments in general.
This paper describes a method for searching for common sets of descriptors between collections of images. The presented method operates on local interest keypoints, which are generated using the SURF algorithm. The use of a dictionary of descriptors allowed achieving good performance of the content-based image retrieval. The method can be used to initially determine a set of similar pairs of keypoints between images. For this purpose, we use a certain level of tolerance between values of descriptors, as values of feature descriptors are almost never equal but similar between different images. After that, the method compares the structure of rotation and location of interest points in one image with the point structure in other images. Thus, we were able to find similar areas in images and determine the level of similarity between them, even when images contain different scenes.
Understanding the connectivity in the brain is an important prerequisite for understanding how the brain processes information. In the Brain/MINDS project, a connectivity study on marmoset brains uses two-photon microscopy fluorescence images of axonal projections to collect the neuron connectivity from defined brain regions at the mesoscopic scale. The processing of the images requires the detection and segmentation of the axonal tracer signal. The objective is to detect as much tracer signal as possible while not misclassifying other background structures as the signal. This can be challenging because of imaging noise, a cluttered image background, distortions or varying image contrast cause problems. We are developing MarmoNet, a pipeline that processes and analyzes tracer image data of the common marmoset brain. The pipeline incorporates state-of-the-art machine learning techniques based on artificial convolutional neural networks (CNN) and image registration techniques to extract and map all relevant information in a robust manner. The pipeline processes new images in a fully automated way. This report introduces the current state of the tracer signal analysis part of the pipeline.
We interpret convolutional networks as adaptive filters and combine them with so-called MuxOut layers to efficiently upscale low resolution images. We formalize this interpretation by deriving a linear and space-variant structure of a convolutional network when its activations are fixed. We introduce general purpose algorithms to analyze a network and show its overall filter effect for each given location. We use this analysis to evaluate two types of image upscalers: deterministic upscalers that target the recovery of details from original content; and second, a new generation of upscalers that can sample the distribution of upscale aliases (images that share the same downscale version) that look like real content.