Efficient Human Epithelial-2 (HEp-2) cell image classification can facilitate the diagnosis of many autoimmune diseases. This paper presents an automatic framework for this classification task, by utilizing the deep convolutional neural networks (CNNs) which have recently attracted intensive attention in visual recognition. This paper elaborates the important components of this framework, discusses multiple key factors that impact the efficiency of training a deep CNN, and systematically compares this framework with the well-established image classification models in the literature. Experiments on benchmark datasets show that i) the proposed framework can effectively outperform existing models by properly applying data augmentation; ii) our CNN-based framework demonstrates excellent adaptability across different datasets, which is highly desirable for classification under varying laboratory settings. Our system is ranked high in the cell image classification competition hosted by ICPR 2014.
The computational prediction algorithm of neural network, or deep learning, has drawn much attention recently in statistics as well as in image recognition and natural language processing. Particularly in statistical application for censored survival data, the loss function used for optimization has been mainly based on the partial likelihood from Cox's model and its variations to utilize existing neural network library such as Keras, which was built upon the open source library of TensorFlow. This paper presents a novel application of the neural network to the quantile regression for survival data with right censoring, which is adjusted by the inverse of the estimated censoring distribution in the check function. The main purpose of this work is to show that the deep learning method could be flexible enough to predict nonlinear patterns more accurately compared to the traditional method even in low-dimensional data, emphasizing on practicality of the method for censored survival data. Simulation studies were performed to generate nonlinear censored survival data and compare the deep learning method with the traditional quantile regression method in terms of prediction accuracy. The proposed method is illustrated with a publicly available breast cancer data set with gene signatures. The source code is freely available at https://github.com/yicjia/DeepQuantreg.
We present an effective method to progressively integrate and refine the cross-modality complementarities for RGB-D salient object detection (SOD). The proposed network mainly solves two challenging issues: 1) how to effectively integrate the complementary information from RGB image and its corresponding depth map, and 2) how to adaptively select more saliency-related features. First, we propose a cross-modality feature modulation (cmFM) module to enhance feature representations by taking the depth features as prior, which models the complementary relations of RGB-D data. Second, we propose an adaptive feature selection (AFS) module to select saliency-related features and suppress the inferior ones. The AFS module exploits multi-modality spatial feature fusion with the self-modality and cross-modality interdependencies of channel features are considered. Third, we employ a saliency-guided position-edge attention (sg-PEA) module to encourage our network to focus more on saliency-related regions. The above modules as a whole, called cmMS block, facilitates the refinement of saliency features in a coarse-to-fine fashion. Coupled with a bottom-up inference, the refined saliency features enable accurate and edge-preserving SOD. Extensive experiments demonstrate that our network outperforms state-of-the-art saliency detectors on six popular RGB-D SOD benchmarks.
In this paper, we are interested in editing text in natural images, which aims to replace or modify a word in the source image with another one while maintaining its realistic look. This task is challenging, as the styles of both background and text need to be preserved so that the edited image is visually indistinguishable from the source image. Specifically, we propose an end-to-end trainable style retention network (SRNet) that consists of three modules: text conversion module, background inpainting module and fusion module. The text conversion module changes the text content of the source image into the target text while keeping the original text style. The background inpainting module erases the original text, and fills the text region with appropriate texture. The fusion module combines the information from the two former modules, and generates the edited text images. To our knowledge, this work is the first attempt to edit text in natural images at the word level. Both visual effects and quantitative results on synthetic and real-world dataset (ICDAR 2013) fully confirm the importance and necessity of modular decomposition. We also conduct extensive experiments to validate the usefulness of our method in various real-world applications such as text image synthesis, augmented reality (AR) translation, information hiding, etc.
Cartoon face detection is a more challenging task than human face detection due to many difficult scenarios is involved. Aiming at the characteristics of cartoon faces, such as huge differences within the intra-faces, in this paper, we propose an asymmetric cartoon face detector, named ACFD. Specifically, it consists of the following modules: a novel backbone VoVNetV3 comprised of several asymmetric one-shot aggregation modules (AOSA), asymmetric bi-directional feature pyramid network (ABi-FPN), dynamic anchor match strategy (DAM) and the corresponding margin binary classification loss (MBC). In particular, to generate features with diverse receptive fields, multi-scale pyramid features are extracted by VoVNetV3, and then fused and enhanced simultaneously by ABi-FPN for handling the faces in some extreme poses and have disparate aspect ratios. Besides, DAM is used to match enough high-quality anchors for each face, and MBC is for the strong power of discrimination. With the effectiveness of these modules, our ACFD achieves the 1st place on the detection track of 2020 iCartoon Face Challenge under the constraints of model size 200MB, inference time 50ms per image, and without any pretrained models.
Currently, the screening of Wagner grades of diabetic feet (DF) still relies on professional podiatrists. However, in less-developed countries, podiatrists are scarce, which led to the majority of undiagnosed patients. In this study, we proposed the real-time detection and location method for Wagner grades of DF based on refinements on YOLOv3. We collected 2,688 data samples and implemented several methods, such as a visual coherent image mixup, label smoothing, and training scheduler revamping, based on the ablation study. The experimental results suggested that the refinements on YOLOv3 achieved an accuracy of 91.95% and the inference speed of a single picture reaches 31ms with the NVIDIA Tesla V100. To test the performance of the model on a smartphone, we deployed the refinements on YOLOv3 models on an Android 9 system smartphone. This work has the potential to lead to a paradigm shift for clinical treatment of the DF in the future, to provide an effective healthcare solution for DF tissue analysis and healing status.
Hashing methods have been widely investigated for fast approximate nearest neighbor searching in large data sets. Most existing methods use binary vectors in lower dimensional spaces to represent data points that are usually real vectors of higher dimensionality. We divide the hashing process into two steps. Data points are first embedded in a low-dimensional space, and the global positioning system method is subsequently introduced but modified for binary embedding. We devise dataindependent and data-dependent methods to distribute the satellites at appropriate locations. Our methods are based on finding the tradeoff between the information losses in these two steps. Experiments show that our data-dependent method outperforms other methods in different-sized data sets from 100k to 10M. By incorporating the orthogonality of the code matrix, both our data-independent and data-dependent methods are particularly impressive in experiments on longer bits.
Gastric cancer is one of the most common cancers, which ranks third among the leading causes of cancer death. Biopsy of gastric mucosal is a standard procedure in gastric cancer screening test. However, manual pathological inspection is labor-intensive and time-consuming. Besides, it is challenging for an automated algorithm to locate the small lesion regions in the gigapixel whole-slide image and make the decision correctly. To tackle these issues, we collected large-scale whole-slide image dataset with detailed lesion region annotation and designed a whole-slide image analyzing framework consisting of 3 networks which could not only determine the screen result but also present the suspicious areas to the pathologist for reference. Experiments demonstrated that our proposed framework achieves sensitivity of 97.05% and specificity of 92.72% in screening task and Dice coefficient of 0.8331 in segmentation task. Furthermore, we tested our best model in real-world scenario on 10, 316 whole-slide images collected from 4 medical centers.
Semi-supervised learning (SSL) provides an effective means of leveraging unlabeled data to improve a model's performance. In this paper, we demonstrate the power of a simple combination of two common SSL methods: consistency regularization and pseudo-labeling. Our algorithm, FixMatch, first generates pseudo-labels using the model's predictions on weakly-augmented unlabeled images. For a given image, the pseudo-label is only retained if the model produces a high-confidence prediction. The model is then trained to predict the pseudo-label when fed a strongly-augmented version of the same image. Despite its simplicity, we show that FixMatch achieves state-of-the-art performance across a variety of standard semi-supervised learning benchmarks, including 94.93% accuracy on CIFAR-10 with 250 labels and 88.61% accuracy with 40 -- just 4 labels per class. Since FixMatch bears many similarities to existing SSL methods that achieve worse performance, we carry out an extensive ablation study to tease apart the experimental factors that are most important to FixMatch's success. We make our code available at https://github.com/google-research/fixmatch.
Image captioning, a challenging task where the machine automatically describes an image by sentences, has drawn significant attention in recent years. Despite the remarkable improvements of recent approaches, however, these methods are built upon a large set of training image-sentence pairs. The expensive labor efforts hence limit the captioning model to describe the wider world. In this paper, we present a novel network structure, Cascaded Revision Network, which aims at relieving the problem by equipping the model with out-of-domain knowledge. CRN first tries its best to describe an image using the existing vocabulary from in-domain knowledge. Due to the lack of out-of-domain knowledge, the caption may be inaccurate or include ambiguous words for the image with unknown (novel) objects. We propose to re-edit the primary captioning sentence by a series of cascaded operations. We introduce a perplexity predictor to find out which words are most likely to be inaccurate given the input image. Thereafter, we utilize external knowledge from a pre-trained object detection model and select more accurate words from detection results by the visual matching module. In the last step, we design a semantic matching module to ensure that the novel object is fit in the right position. By this novel cascaded captioning-revising mechanism, CRN can accurately describe images with unseen objects. We validate the proposed method with state-of-the-art performance on the held-out MSCOCO dataset as well as scale to ImageNet, demonstrating the effectiveness of this method.