The cells and their spatial patterns in the tumor microenvironment (TME) play a key role in tumor evolution, and yet remains an understudied topic in computational pathology. This study, to the best of our knowledge, is among the first to hybrid local and global graph methods to profile orchestration and interaction of cellular components. To address the challenge in hematolymphoid cancers where the cell classes in TME are unclear, we first implemented cell level unsupervised learning and identified two new cell subtypes. Local cell graphs or supercells were built for each image by considering the individual cell's geospatial location and classes. Then, we applied supercell level clustering and identified two new cell communities. In the end, we built global graphs to abstract spatial interaction patterns and extract features for disease diagnosis. We evaluate the proposed algorithm on H\&E slides of 60 hematolymphoid neoplasm patients and further compared it with three cell level graph-based algorithms, including the global cell graph, cluster cell graph, and FLocK. The proposed algorithm achieves a mean diagnosis accuracy of 0.703 with the repeated 5-fold cross-validation scheme. In conclusion, our algorithm shows superior performance over the existing methods and can be potentially applied to other cancer types.
In this paper, we present a novel differential morph detection framework, utilizing landmark and appearance disentanglement. In our framework, the face image is represented in the embedding domain using two disentangled but complementary representations. The network is trained by triplets of face images, in which the intermediate image inherits the landmarks from one image and the appearance from the other image. This initially trained network is further trained for each dataset using contrastive representations. We demonstrate that, by employing appearance and landmark disentanglement, the proposed framework can provide state-of-the-art differential morph detection performance. This functionality is achieved by the using distances in landmark, appearance, and ID domains. The performance of the proposed framework is evaluated using three morph datasets generated with different methodologies.
Out-of-distribution (OOD) detection is an important task in machine learning systems for ensuring their reliability and safety. Deep probabilistic generative models facilitate OOD detection by estimating the likelihood of a data sample. However, such models frequently assign a suspiciously high likelihood to a specific outlier. Several recent works have addressed this issue by training a neural network with auxiliary outliers, which are generated by perturbing the input data. In this paper, we discover that these approaches fail for certain OOD datasets. Thus, we suggest a new detection metric that operates without outlier exposure. We observe that our metric is robust to diverse variations of an image compared to the previous outlier-exposing methods. Furthermore, our proposed score requires neither auxiliary models nor additional training. Instead, this paper utilizes the likelihood ratio statistic in a new perspective to extract genuine properties from the given single deep probabilistic generative model. We also apply a novel numerical approximation to enable fast implementation. Finally, we demonstrate comprehensive experiments on various probabilistic generative models and show that our method achieves state-of-the-art performance.
Multi-Focus Image Fusion seeks to improve the quality of an acquired burst of images with different focus planes. For solving the task, an activity level measurement and a fusion rule are typically established to select and fuse the most relevant information from the sources. However, the design of this kind of method by hand is really hard and sometimes restricted to solution spaces where the optimal all-in-focus images are not contained. Then, we propose here two fast and straightforward approaches for image fusion based on deep neural networks. Our solution uses a multiple source Hourglass architecture trained in an end-to-end fashion. Models are data-driven and can be easily generalized for other kinds of fusion problems. A segmentation approach is used for recognition of the focus map, while the weighted average rule is used for fusion. We designed a training loss function for our regression-based fusion function, which allows the network to learn both the activity level measurement and the fusion rule. Experimental results show our approach has comparable results to the state-of-the-art methods with a 60X increase of computational efficiency for 520X520 resolution images.
The Neural Tangent Kernel (NTK) characterizes the behavior of infinitely-wide neural networks trained under least squares loss by gradient descent. Recent works also report that NTK regression can outperform finitely-wide neural networks trained on small-scale datasets. However, the computational complexity of kernel methods has limited its use in large-scale learning tasks. To accelerate learning with NTK, we design a near input-sparsity time approximation algorithm for NTK, by sketching the polynomial expansions of arc-cosine kernels: our sketch for the convolutional counterpart of NTK (CNTK) can transform any image using a linear runtime in the number of pixels. Furthermore, we prove a spectral approximation guarantee for the NTK matrix, by combining random features (based on leverage score sampling) of the arc-cosine kernels with a sketching algorithm. We benchmark our methods on various large-scale regression and classification tasks and show that a linear regressor trained on our CNTK features matches the accuracy of exact CNTK on CIFAR-10 dataset while achieving 150x speedup.
We propose a new incremental aggregation algorithm for multi-image deblurring with automatic image selection. The primary motivation is that current bursts deblurring methods do not handle well situations in which misalignment or out-of-context frames are present in the burst. These real-life situations result in poor reconstructions or manual selection of the images that will be used to deblur. Automatically selecting best frames within the burst to improve the base reconstruction is challenging because the amount of possible images fusions is equal to the power set cardinal. Here, we approach the multi-image deblurring problem as a two steps process. First, we successfully learn a comparison function to rank a burst of images using a deep convolutional neural network. Then, an incremental Fourier burst accumulation with a reconstruction degradation mechanism is applied fusing only less blurred images that are sufficient to maximize the reconstruction quality. Experiments with the proposed algorithm have shown superior results when compared to other similar approaches, outperforming other methods described in the literature in previously described situations. We validate our findings on several synthetic and real datasets.
The class activation mapping, or CAM, has been the cornerstone of feature attribution methods for multiple vision tasks. Its simplicity and effectiveness have led to wide applications in the explanation of visual predictions and weakly-supervised localization tasks. However, CAM has its own shortcomings. The computation of attribution maps relies on ad-hoc calibration steps that are not part of the training computational graph, making it difficult for us to understand the real meaning of the attribution values. In this paper, we improve CAM by explicitly incorporating a latent variable encoding the location of the cue for recognition in the formulation, thereby subsuming the attribution map into the training computational graph. The resulting model, class activation latent mapping, or CALM, is trained with the expectation-maximization algorithm. Our experiments show that CALM identifies discriminative attributes for image classifiers more accurately than CAM and other visual attribution baselines. CALM also shows performance improvements over prior arts on the weakly-supervised object localization benchmarks. Our code is available at https://github.com/naver-ai/calm.
Non-parametric face modeling aims to reconstruct 3D face only from images without shape assumptions. While plausible facial details are predicted, the models tend to over-depend on local color appearance and suffer from ambiguous noise. To address such problem, this paper presents a novel Learning to Aggregate and Personalize (LAP) framework for unsupervised robust 3D face modeling. Instead of using controlled environment, the proposed method implicitly disentangles ID-consistent and scene-specific face from unconstrained photo set. Specifically, to learn ID-consistent face, LAP adaptively aggregates intrinsic face factors of an identity based on a novel curriculum learning approach with relaxed consistency loss. To adapt the face for a personalized scene, we propose a novel attribute-refining network to modify ID-consistent face with target attribute and details. Based on the proposed method, we make unsupervised 3D face modeling benefit from meaningful image facial structure and possibly higher resolutions. Extensive experiments on benchmarks show LAP recovers superior or competitive face shape and texture, compared with state-of-the-art (SOTA) methods with or without prior and supervision.
Incorporating semantic information into the codecs during image compression can significantly reduce the repetitive computation of fundamental semantic analysis (such as object recognition) in client-side applications. The same practice also enable the compressed code to carry the image semantic information during storage and transmission. In this paper, we propose a concept called Deep Semantic Image Compression (DeepSIC) and put forward two novel architectures that aim to reconstruct the compressed image and generate corresponding semantic representations at the same time. The first architecture performs semantic analysis in the encoding process by reserving a portion of the bits from the compressed code to store the semantic representations. The second performs semantic analysis in the decoding step with the feature maps that are embedded in the compressed code. In both architectures, the feature maps are shared by the compression and the semantic analytics modules. To validate our approaches, we conduct experiments on the publicly available benchmarking datasets and achieve promising results. We also provide a thorough analysis of the advantages and disadvantages of the proposed technique.
Image recovery from compressive measurements requires a signal prior for the images being reconstructed. Recent work has explored the use of deep generative models with low latent dimension as signal priors for such problems. However, their recovery performance is limited by high representation error. We introduce a method for achieving low representation error using generators as signal priors. Using a pre-trained generator, we remove one or more initial blocks at test time and optimize over the new, higher-dimensional latent space to recover a target image. Experiments demonstrate significantly improved reconstruction quality for a variety of network architectures. This approach also works well for out-of-training-distribution images and is competitive with other state-of-the-art methods. Our experiments show that test-time architectural modifications can greatly improve the recovery quality of generator signal priors for compressed sensing.