By training a model on multiple observed source domains, domain generalization aims to generalize well to arbitrary unseen target domains without further training. Existing works mainly focus on learning domain-invariant features to improve the generalization ability. However, since target domain is not available during training, previous methods inevitably suffer from overfitting in source domains. To tackle this issue, we develop an effective dropout-based framework to enlarge the region of the model's attention, which can effectively mitigate the overfitting problem. Particularly, different from the typical dropout scheme, which normally conducts the dropout on the fixed layer, first, we randomly select one layer, and then we randomly select its channels to conduct dropout. Besides, we leverage the progressive scheme to add the ratio of the dropout during training, which can gradually boost the difficulty of training model to enhance the robustness of the model. Moreover, to further alleviate the impact of the overfitting issue, we leverage the augmentation schemes on image-level and feature-level to yield a strong baseline model. We conduct extensive experiments on multiple benchmark datasets, which show our method can outperform the state-of-the-art methods.
We introduce an unsupervised deep manifold learning algorithm for motion-compensated dynamic MRI. We assume that the motion fields in a free-breathing lung MRI dataset live on a manifold. The motion field at each time instant is modeled as the output of a deep generative model, driven by low-dimensional time-varying latent vectors that capture the temporal variability. The images at each time instant are modeled as the deformed version of an image template using the above motion fields. The template, the parameters of the deep generator, and the latent vectors are learned from the k-t space data in an unsupervised fashion. The manifold motion model serves as a regularizer, making the joint estimation of the motion fields and images from few radial spokes/frame well-posed. The utility of the algorithm is demonstrated in the context of motion-compensated high-resolution lung MRI.
In recent years, with the advancement of computer-aided diagnosis (CAD) technology and whole slide image (WSI), histopathological WSI has gradually played a crucial aspect in the diagnosis and analysis of diseases. To increase the objectivity and accuracy of pathologists' work, artificial neural network (ANN) methods have been generally needed in the segmentation, classification, and detection of histopathological WSI. In this paper, WSI analysis methods based on ANN are reviewed. Firstly, the development status of WSI and ANN methods is introduced. Secondly, we summarize the common ANN methods. Next, we discuss publicly available WSI datasets and evaluation metrics. These ANN architectures for WSI processing are divided into classical neural networks and deep neural networks (DNNs) and then analyzed. Finally, the application prospect of the analytical method in this field is discussed. The important potential method is Visual Transformers.
Image analysis tasks in computational pathology are commonly solved using convolutional neural networks (CNNs). The selection of a suitable CNN architecture and hyperparameters is usually done through exploratory iterative optimization, which is computationally expensive and requires substantial manual work. The goal of this article is to evaluate how generic tools for neural network architecture search and hyperparameter optimization perform for common use cases in computational pathology. For this purpose, we evaluated one on-premises and one cloud-based tool for three different classification tasks for histological images: tissue classification, mutation prediction, and grading. We found that the default CNN architectures and parameterizations of the evaluated AutoML tools already yielded classification performance on par with the original publications. Hyperparameter optimization for these tasks did not substantially improve performance, despite the additional computational effort. However, performance varied substantially between classifiers obtained from individual AutoML runs due to non-deterministic effects. Generic CNN architectures and AutoML tools could thus be a viable alternative to manually optimizing CNN architectures and parametrizations. This would allow developers of software solutions for computational pathology to focus efforts on harder-to-automate tasks such as data curation.
In this work, we adhere to explore a Multi-Tasking learning (MTL) based network to perform document attribute classification such as the font type, font size, font emphasis and scanning resolution classification of a document image. To accomplish these tasks, we operate on either segmented word level or on uniformed size patches randomly cropped out of the document. Furthermore, a hybrid convolution neural network (CNN) architecture "MTL+MI", which is based on the combination of MTL and Multi-Instance (MI) of patch and word is used to accomplish joint learning for the classification of the same document attributes. The contribution of this paper are three fold: firstly, based on segmented word images and patches, we present a MTL based network for the classification of a full document image. Secondly, we propose a MTL and MI (using segmented words and patches) based combined CNN architecture ("MTL+MI") for the classification of same document attributes. Thirdly, based on the multi-tasking classifications of the words and/or patches, we propose an intelligent voting system which is based on the posterior probabilities of each words and/or patches to perform the classification of document's attributes of complete document image.
In the existing research of mammogram image classification, either clinical data or image features of a specific type is considered along with the supervised classifiers such as Neural Network (NN) and Support Vector Machine (SVM). This paper considers automated classification of breast tissue type as benign or malignant using Weighted Feature Support Vector Machine (WFSVM) through constructing the precomputed kernel function by assigning more weight to relevant features using the principle of maximizing deviations. Initially, MIAS dataset of mammogram images is divided into training and test set, then the preprocessing techniques such as noise removal and background removal are applied to the input images and the Region of Interest (ROI) is identified. The statistical features and texture features are extracted from the ROI and the clinical features are obtained directly from the dataset. The extracted features of the training dataset are used to construct the weighted features and precomputed linear kernel for training the WFSVM, from which the training model file is created. Using this model file the kernel matrix of test samples is classified as benign or malignant. This analysis shows that the texture features have resulted in better accuracy than the other features with WFSVM and SVM. However, the number of support vectors created in WFSVM is less than the SVM classifier.
The fundamental goal of artificial intelligence (AI) is to mimic the core cognitive activities of human including perception, memory, and reasoning. Although tremendous success has been achieved in various AI research fields (e.g., computer vision and natural language processing), the majority of existing works only focus on acquiring single cognitive ability (e.g., image classification, reading comprehension, or visual commonsense reasoning). To overcome this limitation and take a solid step to artificial general intelligence (AGI), we develop a novel foundation model pre-trained with huge multimodal (visual and textual) data, which is able to be quickly adapted for a broad class of downstream cognitive tasks. Such a model is fundamentally different from the multimodal foundation models recently proposed in the literature that typically make strong semantic correlation assumption and expect exact alignment between image and text modalities in their pre-training data, which is often hard to satisfy in practice thus limiting their generalization abilities. To resolve this issue, we propose to pre-train our foundation model by self-supervised learning with weak semantic correlation data crawled from the Internet and show that state-of-the-art results can be obtained on a wide range of downstream tasks (both single-modal and cross-modal). Particularly, with novel model-interpretability tools developed in this work, we demonstrate that strong imagination ability (even with hints of commonsense) is now possessed by our foundation model. We believe our work makes a transformative stride towards AGI and will have broad impact on various AI+ fields (e.g., neuroscience and healthcare).
Leading neuroimaging studies have pushed 3T MRI acquisition resolutions below 1.0 mm for improved structure definition and morphometry. Yet, only few, time-intensive automated image analysis pipelines have been validated for high-resolution (HiRes) settings. Efficient deep learning approaches, on the other hand, rarely support more than one fixed resolution (usually 1.0 mm). Furthermore, the lack of a standard submillimeter resolution as well as limited availability of diverse HiRes data with sufficient coverage of scanner, age, diseases, or genetic variance poses additional, unsolved challenges for training HiRes networks. Incorporating resolution-independence into deep learning-based segmentation, i.e., the ability to segment images at their native resolution across a range of different voxel sizes, promises to overcome these challenges, yet no such approach currently exists. We now fill this gap by introducing a Voxelsize Independent Neural Network (VINN) for resolution-independent segmentation tasks and present FastSurferVINN, which (i) establishes and implements resolution-independence for deep learning as the first method simultaneously supporting 0.7-1.0 mm whole brain segmentation, (ii) significantly outperforms state-of-the-art methods across resolutions, and (iii) mitigates the data imbalance problem present in HiRes datasets. Overall, internal resolution-independence mutually benefits both HiRes and 1.0 mm MRI segmentation. With our rigorously validated FastSurferVINN we distribute a rapid tool for morphometric neuroimage analysis. The VINN architecture, furthermore, represents an efficient resolution-independent segmentation method for wider application
Conditional generation is a subclass of generative problems where the output of the generation is conditioned by the attribute information. In this paper, we present a stochastic contrastive conditional generative adversarial network (InfoSCC-GAN) with an explorable latent space. The InfoSCC-GAN architecture is based on an unsupervised contrastive encoder built on the InfoNCE paradigm, an attribute classifier and an EigenGAN generator. We propose a novel training method, based on generator regularization using external or internal attributes every $n$-th iteration, using a pre-trained contrastive encoder and a pre-trained classifier. The proposed InfoSCC-GAN is derived based on an information-theoretic formulation of mutual information maximization between input data and latent space representation as well as latent space and generated data. Thus, we demonstrate a link between the training objective functions and the above information-theoretic formulation. The experimental results show that InfoSCC-GAN outperforms the "vanilla" EigenGAN in the image generation on AFHQ and CelebA datasets. In addition, we investigate the impact of discriminator architectures and loss functions by performing ablation studies. Finally, we demonstrate that thanks to the EigenGAN generator, the proposed framework enjoys a stochastic generation in contrast to vanilla deterministic GANs yet with the independent training of encoder, classifier, and generator in contrast to existing frameworks. Code, experimental results, and demos are available online at https://github.com/vkinakh/InfoSCC-GAN.
Nowadays the world has entered into the digital age, in which the data analysis and visualization have become more and more important. In analogy to imaging the real object, we demonstrate that the computational ghost imaging can image the digital data to show their characteristics, such as periodicity. Furthermore, our experimental results show that the use of optical imaging methods to analyse data exhibits unique advantages, especially in anti-interference. The data analysis with computational ghost imaging can be well performed against strong noise, random amplitude and phase changes in the binarized signals. Such robust data data analysis and imaging has an important application prospect in big data analysis, meteorology, astronomy, economics and many other fields.