Placenta Segmentation in Ultrasound Imaging: Addressing Sources of Uncertainty and Limited Field-of-View

Automatic segmentation of the placenta in fetal ultrasound (US) is challenging due to the (i) high diversity of placenta appearance, (ii) the restricted quality in US resulting in highly variable reference annotations, and (iii) the limited field-of-view of US prohibiting whole placenta assessment at late gestation. In this work, we address these three challenges with a multi-task learning approach that combines the classification of placental location (e.g., anterior, posterior) and semantic placenta segmentation in a single convolutional neural network. Through the classification task the model can learn from larger and more diverse datasets while improving the accuracy of the segmentation task in particular in limited training set conditions. With this approach we investigate the variability in annotations from multiple raters and show that our automatic segmentations (Dice of 0.86 for anterior and 0.83 for posterior placentas) achieve human-level performance as compared to intra- and inter-observer variability. Lastly, our approach can deliver whole placenta segmentation using a multi-view US acquisition pipeline consisting of three stages: multi-probe image acquisition, image fusion and image segmentation. This results in high quality segmentation of larger structures such as the placenta in US with reduced image artifacts which are beyond the field-of-view of single probes.

Multiple Selection Extrapolation for Improved Spatial Error Concealment

This contribution introduces a novel signal extrapolation algorithm and its application to image error concealment. The signal extrapolation is carried out by iteratively generating a model of the signal suffering from distortion. Thereby, the model results from a weighted superposition of two-dimensional basis functions whereas in every iteration step a set of these is selected and the approximation residual is projected onto the subspace they span. The algorithm is an improvement to the Frequency Selective Extrapolation that has proven to be an effective method for concealing lost or distorted image regions. Compared to this algorithm, the novel algorithm is able to reduce the processing time by a factor larger than three, by still preserving the very high extrapolation quality.

HistoPerm: A Permutation-Based View Generation Approach for Learning Histopathologic Feature Representations

Recently, deep learning methods have been successfully applied to solve numerous challenges in the field of digital pathology. However, many of these approaches are fully supervised and require annotated images. Annotating a histology image is a time-consuming and tedious process for even a highly skilled pathologist, and, as such, most histology datasets lack region-of-interest annotations and are weakly labeled. In this paper, we introduce HistoPerm, a view generation approach designed for improving the performance of representation learning techniques on histology images in weakly supervised settings. In HistoPerm, we permute augmented views of patches generated from whole-slide histology images to improve classification accuracy. These permuted views belong to the same original slide-level class but are produced from distinct patch instances. We tested adding HistoPerm to BYOL and SimCLR, two prominent representation learning methods, on two public histology datasets for Celiac disease and Renal Cell Carcinoma. For both datasets, we found improved performance in terms of accuracy, F1-score, and AUC compared to the standard BYOL and SimCLR approaches. Particularly, in a linear evaluation configuration, HistoPerm increases classification accuracy on the Celiac disease dataset by 8% for BYOL and 3% for SimCLR. Similarly, with HistoPerm, classification accuracy increases by 2% for BYOL and 0.25% for SimCLR on the Renal Cell Carcinoma dataset. The proposed permutation-based view generation approach can be adopted in common representation learning frameworks to capture histopathology features in weakly supervised settings and can lead to whole-slide classification outcomes that are close to, or even better than, fully supervised methods.

Effectiveness of Function Matching in Driving Scene Recognition

Knowledge distillation is an effective approach for training compact recognizers required in autonomous driving. Recent studies on image classification have shown that matching student and teacher on a wide range of data points is critical for improving performance in distillation. This concept (called function matching) is suitable for driving scene recognition, where generally an almost infinite amount of unlabeled data are available. In this study, we experimentally investigate the impact of using such a large amount of unlabeled data for distillation on the performance of student models in structured prediction tasks for autonomous driving. Through extensive experiments, we demonstrate that the performance of the compact student model can be improved dramatically and even match the performance of the large-scale teacher by knowledge distillation with massive unlabeled data.

Proxy-bridged Image Reconstruction Network for Anomaly Detection in Medical Images

Anomaly detection in medical images refers to the identification of abnormal images with only normal images in the training set. Most existing methods solve this problem with a self-reconstruction framework, which tends to learn an identity mapping and reduces the sensitivity to anomalies. To mitigate this problem, in this paper, we propose a novel Proxy-bridged Image Reconstruction Network (ProxyAno) for anomaly detection in medical images. Specifically, we use an intermediate proxy to bridge the input image and the reconstructed image. We study different proxy types, and we find that the superpixel-image (SI) is the best one. We set all pixels' intensities within each superpixel as their average intensity, and denote this image as SI. The proposed ProxyAno consists of two modules, a Proxy Extraction Module and an Image Reconstruction Module. In the Proxy Extraction Module, a memory is introduced to memorize the feature correspondence for normal image to its corresponding SI, while the memorized correspondence does not apply to the abnormal images, which leads to the information loss for abnormal image and facilitates the anomaly detection. In the Image Reconstruction Module, we map an SI to its reconstructed image. Further, we crop a patch from the image and paste it on the normal SI to mimic the anomalies, and enforce the network to reconstruct the normal image even with the pseudo abnormal SI. In this way, our network enlarges the reconstruction error for anomalies. Extensive experiments on brain MR images, retinal OCT images and retinal fundus images verify the effectiveness of our method for both image-level and pixel-level anomaly detection.

Deep Neural Network Approximation of Invariant Functions through Dynamical Systems

We study the approximation of functions which are invariant with respect to certain permutations of the input indices using flow maps of dynamical systems. Such invariant functions includes the much studied translation-invariant ones involving image tasks, but also encompasses many permutation-invariant functions that finds emerging applications in science and engineering. We prove sufficient conditions for universal approximation of these functions by a controlled equivariant dynamical system, which can be viewed as a general abstraction of deep residual networks with symmetry constraints. These results not only imply the universal approximation for a variety of commonly employed neural network architectures for symmetric function approximation, but also guide the design of architectures with approximation guarantees for applications involving new symmetry requirements.

Decreasing Annotation Burden of Pairwise Comparisons with Human-in-the-Loop Sorting: Application in Medical Image Artifact Rating

Ranking by pairwise comparisons has shown improved reliability over ordinal classification. However, as the annotations of pairwise comparisons scale quadratically, this becomes less practical when the dataset is large. We propose a method for reducing the number of pairwise comparisons required to rank by a quantitative metric, demonstrating the effectiveness of the approach in ranking medical images by image quality in this proof of concept study. Using the medical image annotation software that we developed, we actively subsample pairwise comparisons using a sorting algorithm with a human rater in the loop. We find that this method substantially reduces the number of comparisons required for a full ordinal ranking without compromising inter-rater reliability when compared to pairwise comparisons without sorting.

Unsupervised Low-Light Image Enhancement via Histogram Equalization Prior

Deep learning-based methods for low-light image enhancement typically require enormous paired training data, which are impractical to capture in real-world scenarios. Recently, unsupervised approaches have been explored to eliminate the reliance on paired training data. However, they perform erratically in diverse real-world scenarios due to the absence of priors. To address this issue, we propose an unsupervised low-light image enhancement method based on an effective prior termed histogram equalization prior (HEP). Our work is inspired by the interesting observation that the feature maps of histogram equalization enhanced image and the ground truth are similar. Specifically, we formulate the HEP to provide abundant texture and luminance information. Embedded into a Light Up Module (LUM), it helps to decompose the low-light images into illumination and reflectance maps, and the reflectance maps can be regarded as restored images. However, the derivation based on Retinex theory reveals that the reflectance maps are contaminated by noise. We introduce a Noise Disentanglement Module (NDM) to disentangle the noise and content in the reflectance maps with the reliable aid of unpaired clean images. Guided by the histogram equalization prior and noise disentanglement, our method can recover finer details and is more capable to suppress noise in real-world low-light scenarios. Extensive experiments demonstrate that our method performs favorably against the state-of-the-art unsupervised low-light enhancement algorithms and even matches the state-of-the-art supervised algorithms.

Evolution of Activation Functions for Deep Learning-Based Image Classification

Activation functions (AFs) play a pivotal role in the performance of neural networks. The Rectified Linear Unit (ReLU) is currently the most commonly used AF. Several replacements to ReLU have been suggested but improvements have proven inconsistent. Some AFs exhibit better performance for specific tasks, but it is hard to know a priori how to select the appropriate one(s). Studying both standard fully connected neural networks (FCNs) and convolutional neural networks (CNNs), we propose a novel, three-population, coevolutionary algorithm to evolve AFs, and compare it to four other methods, both evolutionary and non-evolutionary. Tested on four datasets -- MNIST, FashionMNIST, KMNIST, and USPS -- coevolution proves to be a performant algorithm for finding good AFs and AF architectures.

Medical Knowledge-Guided Deep Learning for Imbalanced Medical Image Classification

Deep learning models have gained remarkable performance on a variety of image classification tasks. However, many models suffer from limited performance in clinical or medical settings when data are imbalanced. To address this challenge, we propose a medical-knowledge-guided one-class classification approach that leverages domain-specific knowledge of classification tasks to boost the model's performance. The rationale behind our approach is that some existing prior medical knowledge can be incorporated into data-driven deep learning to facilitate model learning. We design a deep learning-based one-class classification pipeline for imbalanced image classification, and demonstrate in three use cases how we take advantage of medical knowledge of each specific classification task by generating additional middle classes to achieve higher classification performances. We evaluate our approach on three different clinical image classification tasks (a total of 8459 images) and show superior model performance when compared to six state-of-the-art methods. All codes of this work will be publicly available upon acceptance of the paper.