The double machine learning (DML) method combines the predictive power of machine learning with statistical estimation to conduct inference about the structural parameter of interest. This paper presents the R package `xtdml`, which implements DML methods for partially linear panel regression models with low-dimensional fixed effects, high-dimensional confounding variables, proposed by Clarke and Polselli (2025). The package provides functionalities to: (a) learn nuisance functions with machine learning algorithms from the `mlr3` ecosystem, (b) handle unobserved individual heterogeneity choosing among first-difference transformation, within-group transformation, and correlated random effects, (c) transform the covariates with min-max normalization and polynomial expansion to improve learning performance. We showcase the use of `xtdml` with both simulated and real longitudinal data.