Talk2AI is a large-scale longitudinal dataset of 3,080 conversations (totaling 30,800 turns) between human participants and Large Language Models (LLMs), designed to support research on persuasion, opinion change, and human-AI interaction. The corpus was collected from 770 profiled Italian adults across four weekly sessions in Spring 2025, using a within-subject design in which each participant conversed with a single model (GPT-4o, Claude Sonnet 3.7, DeepSeek-chat V3, or Mistral Large) on three socially relevant topics: climate change, math anxiety, and health misinformation. Each conversation is linked to rich contextual data, including sociodemographic characteristics and psychometric profiles. After each session, participants reported on opinion change, conviction stability, perceived humanness of the AI, and behavioral intentions, enabling fine-grained longitudinal analysis of how AI-mediated dialogue shapes beliefs and attitudes over time.