We introduce neural network architectures that combine physics-informed neural networks (PINNs) with the immersed boundary method (IBM) to solve fluid-structure interaction (FSI) problems. Our approach features two distinct architectures: a Single-FSI network with a unified parameter space, and an innovative Eulerian-Lagrangian network that maintains separate parameter spaces for fluid and structure domains. We study each architecture using standard Tanh and adaptive B-spline activation functions. Empirical studies on a 2D cavity flow problem involving a moving solid structure show that the Eulerian-Lagrangian architecture performs significantly better. The adaptive B-spline activation further enhances accuracy by providing locality-aware representation near boundaries. While our methodology shows promising results in predicting the velocity field, pressure recovery remains challenging due to the absence of explicit force-coupling constraints in the current formulation. Our findings underscore the importance of domain-specific architectural design and adaptive activation functions for modeling FSI problems within the PINN framework.