Dynamic metasurface antennas (DMAs) are a promising hybrid analog/digital beamforming technology to realize next-generation wireless systems with low cost, footprint, and power consumption. The research on DMA-empowered wireless systems is still at an early stage, mostly limited to theoretical studies under simplifying assumptions on the one hand and a few antenna-level experiments on the other hand. Substantial knowledge gaps arise from the lack of complete end-to-end DMA-empowered wireless system prototypes. In addition, recently unveiled benefits of strong inter-element mutual coupling (MC) in DMAs remain untapped. Here, we demonstrate a K-band prototype of an end-to-end wireless system based on a DMA with strong inter-element MC. To showcase the flexible control over the DMA's radiation pattern, we present an experimental case study of simultaneously steering a beam to a desired transmitter and a null to an undesired jammer, achieving up to 43~dB discrimination. Using software-defined radios, we transmit and receive QPSK OFDM waveforms to evaluate the bit error rate. We also discuss algorithmic and technological challenges associated with envisioned future evolutions of our end-to-end testbed and real-life DMA-based wireless systems.