As an important upstream task for many medical applications, supervised landmark localization still requires non-negligible annotation costs to achieve desirable performance. Besides, due to cumbersome collection procedures, the limited size of medical landmark datasets impacts the effectiveness of large-scale self-supervised pre-training methods. To address these challenges, we propose a two-stage framework for one-shot medical landmark localization, which first infers landmarks by unsupervised registration from the labeled exemplar to unlabeled targets, and then utilizes these noisy pseudo labels to train robust detectors. To handle the significant structure variations, we learn an end-to-end cascade of global alignment and local deformations, under the guidance of novel loss functions which incorporate edge information. In stage II, we explore self-consistency for selecting reliable pseudo labels and cross-consistency for semi-supervised learning. Our method achieves state-of-the-art performances on public datasets of different body parts, which demonstrates its general applicability.
Deep models trained with noisy labels are prone to over-fitting and struggle in generalization. Most existing solutions are based on an ideal assumption that the label noise is class-conditional, i.e., instances of the same class share the same noise model, and are independent of features. While in practice, the real-world noise patterns are usually more fine-grained as instance-dependent ones, which poses a big challenge, especially in the presence of inter-class imbalance. In this paper, we propose a two-stage clean samples identification method to address the aforementioned challenge. First, we employ a class-level feature clustering procedure for the early identification of clean samples that are near the class-wise prediction centers. Notably, we address the class imbalance problem by aggregating rare classes according to their prediction entropy. Second, for the remaining clean samples that are close to the ground truth class boundary (usually mixed with the samples with instance-dependent noises), we propose a novel consistency-based classification method that identifies them using the consistency of two classifier heads: the higher the consistency, the larger the probability that a sample is clean. Extensive experiments on several challenging benchmarks demonstrate the superior performance of our method against the state-of-the-art.
Although deep learning algorithms have been intensively developed for computer-aided tuberculosis diagnosis (CTD), they mainly depend on carefully annotated datasets, leading to much time and resource consumption. Weakly supervised learning (WSL), which leverages coarse-grained labels to accomplish fine-grained tasks, has the potential to solve this problem. In this paper, we first propose a new large-scale tuberculosis (TB) chest X-ray dataset, namely the tuberculosis chest X-ray attribute dataset (TBX-Att), and then establish an attribute-assisted weakly-supervised framework to classify and localize TB by leveraging the attribute information to overcome the insufficiency of supervision in WSL scenarios. Specifically, first, the TBX-Att dataset contains 2000 X-ray images with seven kinds of attributes for TB relational reasoning, which are annotated by experienced radiologists. It also includes the public TBX11K dataset with 11200 X-ray images to facilitate weakly supervised detection. Second, we exploit a multi-scale feature interaction model for TB area classification and detection with attribute relational reasoning. The proposed model is evaluated on the TBX-Att dataset and will serve as a solid baseline for future research. The code and data will be available at https://github.com/GangmingZhao/tb-attribute-weak-localization.
Domain Adaptive Object Detection (DAOD) focuses on improving the generalization ability of object detectors via knowledge transfer. Recent advances in DAOD strive to change the emphasis of the adaptation process from global to local in virtue of fine-grained feature alignment methods. However, both the global and local alignment approaches fail to capture the topological relations among different foreground objects as the explicit dependencies and interactions between and within domains are neglected. In this case, only seeking one-vs-one alignment does not necessarily ensure the precise knowledge transfer. Moreover, conventional alignment-based approaches may be vulnerable to catastrophic overfitting regarding those less transferable regions (e.g. backgrounds) due to the accumulation of inaccurate localization results in the target domain. To remedy these issues, we first formulate DAOD as an open-set domain adaptation problem, in which the foregrounds and backgrounds are seen as the ``known classes'' and ``unknown class'' respectively. Accordingly, we propose a new and general framework for DAOD, named Foreground-aware Graph-based Relational Reasoning (FGRR), which incorporates graph structures into the detection pipeline to explicitly model the intra- and inter-domain foreground object relations on both pixel and semantic spaces, thereby endowing the DAOD model with the capability of relational reasoning beyond the popular alignment-based paradigm. The inter-domain visual and semantic correlations are hierarchically modeled via bipartite graph structures, and the intra-domain relations are encoded via graph attention mechanisms. Empirical results demonstrate that the proposed FGRR exceeds the state-of-the-art performance on four DAOD benchmarks.
Due to its safety-critical property, the image-based diagnosis is desired to achieve robustness on out-of-distribution (OOD) samples. A natural way towards this goal is capturing only clinically disease-related features, which is composed of macroscopic attributes (e.g., margins, shapes) and microscopic image-based features (e.g., textures) of lesion-related areas. However, such disease-related features are often interweaved with data-dependent (but disease irrelevant) biases during learning, disabling the OOD generalization. To resolve this problem, we propose a novel framework, namely Domain Invariant Model with Graph Convolutional Network (DIM-GCN), which only exploits invariant disease-related features from multiple domains. Specifically, we first propose a Bayesian network, which explicitly decomposes the latent variables into disease-related and other disease-irrelevant parts that are provable to be disentangled from each other. Guided by this, we reformulate the objective function based on Variational Auto-Encoder, in which the encoder in each domain has two branches: the domain-independent and -dependent ones, which respectively encode disease-related and -irrelevant features. To better capture the macroscopic features, we leverage the observed clinical attributes as a goal for reconstruction, via Graph Convolutional Network (GCN). Finally, we only implement the disease-related features for prediction. The effectiveness and utility of our method are demonstrated by the superior OOD generalization performance over others on mammogram benign/malignant diagnosis.
Synthesizing a subject-specific pathology-free image from a pathological image is valuable for algorithm development and clinical practice. In recent years, several approaches based on the Generative Adversarial Network (GAN) have achieved promising results in pseudo-healthy synthesis. However, the discriminator (i.e., a classifier) in the GAN cannot accurately identify lesions and further hampers from generating admirable pseudo-healthy images. To address this problem, we present a new type of discriminator, the segmentor, to accurately locate the lesions and improve the visual quality of pseudo-healthy images. Then, we apply the generated images into medical image enhancement and utilize the enhanced results to cope with the low contrast problem existing in medical image segmentation. Furthermore, a reliable metric is proposed by utilizing two attributes of label noise to measure the health of synthetic images. Comprehensive experiments on the T2 modality of BraTS demonstrate that the proposed method substantially outperforms the state-of-the-art methods. The method achieves better performance than the existing methods with only 30\% of the training data. The effectiveness of the proposed method is also demonstrated on the LiTS and the T1 modality of BraTS. The code and the pre-trained model of this study are publicly available at https://github.com/Au3C2/Generator-Versus-Segmentor.
Recent Semi-Supervised Object Detection (SS-OD) methods are mainly based on self-training, i.e., generating hard pseudo-labels by a teacher model on unlabeled data as supervisory signals. Although they achieved certain success, the limited labeled data in semi-supervised learning scales up the challenges of object detection. We analyze the challenges these methods meet with the empirical experiment results. We find that the massive False Negative samples and inferior localization precision lack consideration. Besides, the large variance of object sizes and class imbalance (i.e., the extreme ratio between background and object) hinder the performance of prior arts. Further, we overcome these challenges by introducing a novel approach, Scale-Equivalent Distillation (SED), which is a simple yet effective end-to-end knowledge distillation framework robust to large object size variance and class imbalance. SED has several appealing benefits compared to the previous works. (1) SED imposes a consistency regularization to handle the large scale variance problem. (2) SED alleviates the noise problem from the False Negative samples and inferior localization precision. (3) A re-weighting strategy can implicitly screen the potential foreground regions of the unlabeled data to reduce the effect of class imbalance. Extensive experiments show that SED consistently outperforms the recent state-of-the-art methods on different datasets with significant margins. For example, it surpasses the supervised counterpart by more than 10 mAP when using 5% and 10% labeled data on MS-COCO.
Domain generalization (DG) aims to improve the generalization performance for an unseen target domain by using the knowledge of multiple seen source domains. Mainstream DG methods typically assume that the domain label of each source sample is known a priori, which is challenged to be satisfied in many real-world applications. In this paper, we study a practical problem of compound DG, which relaxes the discrete domain assumption to the mixed source domains setting. On the other hand, current DG algorithms prioritize the focus on semantic invariance across domains (one-vs-one), while paying less attention to the holistic semantic structure (many-vs-many). Such holistic semantic structure, referred to as meta-knowledge here, is crucial for learning generalizable representations. To this end, we present Compound Domain Generalization via Meta-Knowledge Encoding (COMEN), a general approach to automatically discover and model latent domains in two steps. Firstly, we introduce Style-induced Domain-specific Normalization (SDNorm) to re-normalize the multi-modal underlying distributions, thereby dividing the mixture of source domains into latent clusters. Secondly, we harness the prototype representations, the centroids of classes, to perform relational modeling in the embedding space with two parallel and complementary modules, which explicitly encode the semantic structure for the out-of-distribution generalization. Experiments on four standard DG benchmarks reveal that COMEN exceeds the state-of-the-art performance without the need of domain supervision.
This paper presents new hierarchically cascaded transformers that can improve data efficiency through attribute surrogates learning and spectral tokens pooling. Vision transformers have recently been thought of as a promising alternative to convolutional neural networks for visual recognition. But when there is no sufficient data, it gets stuck in overfitting and shows inferior performance. To improve data efficiency, we propose hierarchically cascaded transformers that exploit intrinsic image structures through spectral tokens pooling and optimize the learnable parameters through latent attribute surrogates. The intrinsic image structure is utilized to reduce the ambiguity between foreground content and background noise by spectral tokens pooling. And the attribute surrogate learning scheme is designed to benefit from the rich visual information in image-label pairs instead of simple visual concepts assigned by their labels. Our Hierarchically Cascaded Transformers, called HCTransformers, is built upon a self-supervised learning framework DINO and is tested on several popular few-shot learning benchmarks. In the inductive setting, HCTransformers surpass the DINO baseline by a large margin of 9.7% 5-way 1-shot accuracy and 9.17% 5-way 5-shot accuracy on miniImageNet, which demonstrates HCTransformers are efficient to extract discriminative features. Also, HCTransformers show clear advantages over SOTA few-shot classification methods in both 5-way 1-shot and 5-way 5-shot settings on four popular benchmark datasets, including miniImageNet, tieredImageNet, FC100, and CIFAR-FS. The trained weights and codes are available at https://github.com/StomachCold/HCTransformers.
Semantic segmentation of point cloud usually relies on dense annotation that is exhausting and costly, so it attracts wide attention to investigate solutions for the weakly supervised scheme with only sparse points annotated. Existing works start from the given labels and propagate them to highly-related but unlabeled points, with the guidance of data, e.g. intra-point relation. However, it suffers from (i) the inefficient exploitation of data information, and (ii) the strong reliance on labels thus is easily suppressed when given much fewer annotations. Therefore, we propose a novel framework, PointMatch, that stands on both data and label, by applying consistency regularization to sufficiently probe information from data itself and leveraging weak labels as assistance at the same time. By doing so, meaningful information can be learned from both data and label for better representation learning, which also enables the model more robust to the extent of label sparsity. Simple yet effective, the proposed PointMatch achieves the state-of-the-art performance under various weakly-supervised schemes on both ScanNet-v2 and S3DIS datasets, especially on the settings with extremely sparse labels, e.g. surpassing SQN by 21.2% and 17.2% on the 0.01% and 0.1% setting of ScanNet-v2, respectively.