With the growing deployment of large language models (LLMs) across various applications, assessing the influence of gender biases embedded in LLMs becomes crucial. The topic of gender bias within the realm of natural language processing (NLP) has gained considerable focus, particularly in the context of English. Nonetheless, the investigation of gender bias in languages other than English is still relatively under-explored and insufficiently analyzed. In this work, We examine gender bias in LLMs-generated outputs for different languages. We use three measurements: 1) gender bias in selecting descriptive words given the gender-related context. 2) gender bias in selecting gender-related pronouns (she/he) given the descriptive words. 3) gender bias in the topics of LLM-generated dialogues. We investigate the outputs of the GPT series of LLMs in various languages using our three measurement methods. Our findings revealed significant gender biases across all the languages we examined.
This study explores the mechanism of factual knowledge storage in pre-trained language models (PLMs). Previous research suggests that factual knowledge is stored within multi-layer perceptron weights, and some storage units exhibit degeneracy, referred to as Degenerate Knowledge Neurons (DKNs). This paper provides a comprehensive definition of DKNs that covers both structural and functional aspects, pioneering the study of structures in PLMs' factual knowledge storage units. Based on this, we introduce the Neurological Topology Clustering method, which allows the formation of DKNs in any numbers and structures, leading to a more accurate DKN acquisition. Furthermore, we introduce the Neuro-Degeneracy Analytic Analysis Framework, which uniquely integrates model robustness, evolvability, and complexity for a holistic assessment of PLMs. Within this framework, our execution of 34 experiments across 2 PLMs, 4 datasets, and 6 settings highlights the critical role of DKNs. The code will be available soon.
This paper introduces a novel contextual bandit algorithm for personalized pricing under utility fairness constraints in scenarios with uncertain demand, achieving an optimal regret upper bound. Our approach, which incorporates dynamic pricing and demand learning, addresses the critical challenge of fairness in pricing strategies. We first delve into the static full-information setting to formulate an optimal pricing policy as a constrained optimization problem. Here, we propose an approximation algorithm for efficiently and approximately computing the ideal policy. We also use mathematical analysis and computational studies to characterize the structures of optimal contextual pricing policies subject to fairness constraints, deriving simplified policies which lays the foundations of more in-depth research and extensions. Further, we extend our study to dynamic pricing problems with demand learning, establishing a non-standard regret lower bound that highlights the complexity added by fairness constraints. Our research offers a comprehensive analysis of the cost of fairness and its impact on the balance between utility and revenue maximization. This work represents a step towards integrating ethical considerations into algorithmic efficiency in data-driven dynamic pricing.
Coronary artery disease (CAD) remains the leading cause of death worldwide. Patients with suspected CAD undergo coronary CT angiography (CCTA) to evaluate the risk of cardiovascular events and determine the treatment. Clinical analysis of coronary arteries in CCTA comprises the identification of atherosclerotic plaque, as well as the grading of any coronary artery stenosis typically obtained through the CAD-Reporting and Data System (CAD-RADS). This requires analysis of the coronary lumen and plaque. While voxel-wise segmentation is a commonly used approach in various segmentation tasks, it does not guarantee topologically plausible shapes. To address this, in this work, we propose to directly infer surface meshes for coronary artery lumen and plaque based on a centerline prior and use it in the downstream task of CAD-RADS scoring. The method is developed and evaluated using a total of 2407 CCTA scans. Our method achieved lesion-wise volume intraclass correlation coefficients of 0.98, 0.79, and 0.85 for calcified, non-calcified, and total plaque volume respectively. Patient-level CAD-RADS categorization was evaluated on a representative hold-out test set of 300 scans, for which the achieved linearly weighted kappa ($\kappa$) was 0.75. CAD-RADS categorization on the set of 658 scans from another hospital and scanner led to a $\kappa$ of 0.71. The results demonstrate that direct inference of coronary artery meshes for lumen and plaque is feasible, and allows for the automated prediction of routinely performed CAD-RADS categorization.
In stochastic zeroth-order optimization, a problem of practical relevance is understanding how to fully exploit the local geometry of the underlying objective function. We consider a fundamental setting in which the objective function is quadratic, and provide the first tight characterization of the optimal Hessian-dependent sample complexity. Our contribution is twofold. First, from an information-theoretic point of view, we prove tight lower bounds on Hessian-dependent complexities by introducing a concept called energy allocation, which captures the interaction between the searching algorithm and the geometry of objective functions. A matching upper bound is obtained by solving the optimal energy spectrum. Then, algorithmically, we show the existence of a Hessian-independent algorithm that universally achieves the asymptotic optimal sample complexities for all Hessian instances. The optimal sample complexities achieved by our algorithm remain valid for heavy-tailed noise distributions, which are enabled by a truncation method.
Knowledge graph completion (KGC) aims to solve the incompleteness of knowledge graphs (KGs) by predicting missing links from known triples, numbers of knowledge graph embedding (KGE) models have been proposed to perform KGC by learning embeddings. Nevertheless, most existing embedding models map each relation into a unique vector, overlooking the specific fine-grained semantics of them under different entities. Additionally, the few available fine-grained semantic models rely on clustering algorithms, resulting in limited performance and applicability due to the cumbersome two-stage training process. In this paper, we present a novel method utilizing contextual dictionary lookup, enabling conventional embedding models to learn fine-grained semantics of relations in an end-to-end manner. More specifically, we represent each relation using a dictionary that contains multiple latent semantics. The composition of a given entity and the dictionary's central semantics serves as the context for generating a lookup, thus determining the fine-grained semantics of the relation adaptively. The proposed loss function optimizes both the central and fine-grained semantics simultaneously to ensure their semantic consistency. Besides, we introduce two metrics to assess the validity and accuracy of the dictionary lookup operation. We extend several KGE models with the method, resulting in substantial performance improvements on widely-used benchmark datasets.
NMT systems trained on Pre-trained Multilingual Sequence-Sequence (PMSS) models flounder when sufficient amounts of parallel data is not available for fine-tuning. This specifically holds for languages missing/under-represented in these models. The problem gets aggravated when the data comes from different domains. In this paper, we show that intermediate-task fine-tuning (ITFT) of PMSS models is extremely beneficial for domain-specific NMT, especially when target domain data is limited/unavailable and the considered languages are missing or under-represented in the PMSS model. We quantify the domain-specific results variations using a domain-divergence test, and show that ITFT can mitigate the impact of domain divergence to some extent.
In this paper, a semantic communication framework for image transmission is developed. In the investigated framework, a set of servers cooperatively transmit images to a set of users utilizing semantic communication techniques. To evaluate the performance of studied semantic communication system, a multimodal metric is proposed to measure the correlation between the extracted semantic information and the original image. To meet the ISS requirement of each user, each server must jointly determine the semantic information to be transmitted and the resource blocks (RBs) used for semantic information transmission. We formulate this problem as an optimization problem aiming to minimize each server's transmission latency while reaching the ISS requirement. To solve this problem, a value decomposition based entropy-maximized multi-agent reinforcement learning (RL) is proposed, which enables servers to coordinate for training and execute RB allocation in a distributed manner to approach to a globally optimal performance with less training iterations. Compared to traditional multi-agent RL, the proposed RL improves the valuable action exploration of servers and the probability of finding a globally optimal RB allocation policy based on local observation. Simulation results show that the proposed algorithm can reduce the transmission delay by up to 16.1% compared to traditional multi-agent RL.
In the field of antibody engineering, an essential task is to design a novel antibody whose paratopes bind to a specific antigen with correct epitopes. Understanding antibody structure and its paratope can facilitate a mechanistic understanding of its function. Therefore, antibody structure prediction from its sequence alone has always been a highly valuable problem for de novo antibody design. AlphaFold2, a breakthrough in the field of structural biology, provides a solution to predict protein structure based on protein sequences and computationally expensive coevolutionary multiple sequence alignments (MSAs). However, the computational efficiency and undesirable prediction accuracy of antibodies, especially on the complementarity-determining regions (CDRs) of antibodies limit their applications in the industrially high-throughput drug design. To learn an informative representation of antibodies, we employed a deep antibody language model (ALM) on curated sequences from the observed antibody space database via a transformer model. We also developed a novel model named xTrimoABFold to predict antibody structure from antibody sequence based on the pretrained ALM as well as efficient evoformers and structural modules. The model was trained end-to-end on the antibody structures in PDB by minimizing the ensemble loss of domain-specific focal loss on CDR and the frame-aligned point loss. xTrimoABFold outperforms AlphaFold2 and other protein language model based SOTAs, e.g., OmegaFold, HelixFold-Single, and IgFold with a large significant margin (30+\% improvement on RMSD) while performing 151 times faster than AlphaFold2. To the best of our knowledge, xTrimoABFold achieved state-of-the-art antibody structure prediction. Its improvement in both accuracy and efficiency makes it a valuable tool for de novo antibody design and could make further improvements in immuno-theory.