Prostate cancer is the most common noncutaneous cancer in the world. Recently, multi-modality transrectal ultrasound (TRUS) has increasingly become an effective tool for the guidance of prostate biopsies. With the aim of effectively identifying prostate cancer, we propose a framework for the classification of clinically significant prostate cancer (csPCa) from multi-modality TRUS videos. The framework utilizes two 3D ResNet-50 models to extract features from B-mode images and shear wave elastography images, respectively. An adaptive spatial fusion module is introduced to aggregate two modalities' features. An orthogonal regularized loss is further used to mitigate feature redundancy. The proposed framework is evaluated on an in-house dataset containing 512 TRUS videos, and achieves favorable performance in identifying csPCa with an area under curve (AUC) of 0.84. Furthermore, the visualized class activation mapping (CAM) images generated from the proposed framework may provide valuable guidance for the localization of csPCa, thus facilitating the TRUS-guided targeted biopsy. Our code is publicly available at https://github.com/2313595986/ProstateTRUS.
Recently, large language models (LLM) based generative AI has been gaining momentum for their impressive high-quality performances in multiple domains, particularly after the release of the ChatGPT. Many believe that they have the potential to perform general-purpose problem-solving in software development and replace human software developers. Nevertheless, there are in a lack of serious investigation into the capability of these LLM techniques in fulfilling software development tasks. In a controlled 2 $\times$ 2 between-subject experiment with 109 participants, we examined whether and to what degree working with ChatGPT was helpful in the coding task and typical software development task and how people work with ChatGPT. We found that while ChatGPT performed well in solving simple coding problems, its performance in supporting typical software development tasks was not that good. We also observed the interactions between participants and ChatGPT and found the relations between the interactions and the outcomes. Our study thus provides first-hand insights into using ChatGPT to fulfill software engineering tasks with real-world developers and motivates the need for novel interaction mechanisms that help developers effectively work with large language models to achieve desired outcomes.
We propose the integration of sentiment analysis and deep-reinforcement learning ensemble algorithms for stock trading, and design a strategy capable of dynamically altering its employed agent given concurrent market sentiment. In particular, we create a simple-yet-effective method for extracting news sentiment and combine this with general improvements upon existing works, resulting in automated trading agents that effectively consider both qualitative market factors and quantitative stock data. We show that our approach results in a strategy that is profitable, robust, and risk-minimal -- outperforming the traditional ensemble strategy as well as single agent algorithms and market metrics. Our findings determine that the conventional practice of switching ensemble agents every fixed-number of months is sub-optimal, and that a dynamic sentiment-based framework greatly unlocks additional performance within these agents. Furthermore, as we have designed our algorithm with simplicity and efficiency in mind, we hypothesize that the transition of our method from historical evaluation towards real-time trading with live data should be relatively simple.
Multi-modal Large Language Models (MLLMs) have shown impressive abilities in generating reasonable responses with respect to multi-modal contents. However, there is still a wide gap between the performance of recent MLLM-based applications and the expectation of the broad public, even though the most powerful OpenAI's GPT-4 and Google's Gemini have been deployed. This paper strives to enhance understanding of the gap through the lens of a qualitative study on the generalizability, trustworthiness, and causal reasoning capabilities of recent proprietary and open-source MLLMs across four modalities: ie, text, code, image, and video, ultimately aiming to improve the transparency of MLLMs. We believe these properties are several representative factors that define the reliability of MLLMs, in supporting various downstream applications. To be specific, we evaluate the closed-source GPT-4 and Gemini and 6 open-source LLMs and MLLMs. Overall we evaluate 230 manually designed cases, where the qualitative results are then summarized into 12 scores (ie, 4 modalities times 3 properties). In total, we uncover 14 empirical findings that are useful to understand the capabilities and limitations of both proprietary and open-source MLLMs, towards more reliable downstream multi-modal applications.
Explaining multivariate time series is a compound challenge, as it requires identifying important locations in the time series and matching complex temporal patterns. Although previous saliency-based methods addressed the challenges, their perturbation may not alleviate the distribution shift issue, which is inevitable especially in heterogeneous samples. We present ContraLSP, a locally sparse model that introduces counterfactual samples to build uninformative perturbations but keeps distribution using contrastive learning. Furthermore, we incorporate sample-specific sparse gates to generate more binary-skewed and smooth masks, which easily integrate temporal trends and select the salient features parsimoniously. Empirical studies on both synthetic and real-world datasets show that ContraLSP outperforms state-of-the-art models, demonstrating a substantial improvement in explanation quality for time series data. The source code is available at \url{https://github.com/zichuan-liu/ContraLSP}.
Foundation models characterized by extensive parameters and trained on large-scale datasets have demonstrated remarkable efficacy across various downstream tasks for remote sensing data. Current remote sensing foundation models typically specialize in a single modality or a specific spatial resolution range, limiting their versatility for downstream datasets. While there have been attempts to develop multi-modal remote sensing foundation models, they typically employ separate vision encoders for each modality or spatial resolution, necessitating a switch in backbones contingent upon the input data. To address this issue, we introduce a simple yet effective method, termed OFA-Net (One-For-All Network): employing a single, shared Transformer backbone for multiple data modalities with different spatial resolutions. Using the masked image modeling mechanism, we pre-train a single Transformer backbone on a curated multi-modal dataset with this simple design. Then the backbone model can be used in different downstream tasks, thus forging a path towards a unified foundation backbone model in Earth vision. The proposed method is evaluated on 12 distinct downstream tasks and demonstrates promising performance.
Time series forecasting is crucial and challenging in the real world. The recent surge in interest regarding time series foundation models, which cater to a diverse array of downstream tasks, is noteworthy. However, existing methods often overlook the multi-scale nature of time series, an aspect crucial for precise forecasting. To bridge this gap, we propose HiMTM, a hierarchical multi-scale masked time series modeling method designed for long-term forecasting. Specifically, it comprises four integral components: (1) hierarchical multi-scale transformer (HMT) to capture temporal information at different scales; (2) decoupled encoder-decoder (DED) forces the encoder to focus on feature extraction, while the decoder to focus on pretext tasks; (3) multi-scale masked reconstruction (MMR) provides multi-stage supervision signals for pre-training; (4) cross-scale attention fine-tuning (CSA-FT) to capture dependencies between different scales for forecasting. Collectively, these components enhance multi-scale feature extraction capabilities in masked time series modeling and contribute to improved prediction accuracy. We conduct extensive experiments on 7 mainstream datasets to prove that HiMTM has obvious advantages over contemporary self-supervised and end-to-end learning methods. The effectiveness of HiMTM is further showcased by its application in the industry of natural gas demand forecasting.
Energy forecasting is pivotal in energy systems, by providing fundamentals for operation, with different horizons and resolutions. Though energy forecasting has been widely studied for capturing temporal information, very few works concentrate on the frequency information provided by forecasts. They are consequently often limited to single-resolution applications (e.g., hourly). Here, we propose a unified energy forecasting framework based on Laplace transform in the multi-resolution context. The forecasts can be seamlessly produced at different desired resolutions without re-training or post-processing. Case studies on both energy demand and supply data show that the forecasts from our proposed method can provide accurate information in both time and frequency domains. Across the resolutions, the forecasts also demonstrate high consistency. More importantly, we explore the operational effects of our produced forecasts in the day-ahead and intra-day energy scheduling. The relationship between (i) errors in both time and frequency domains and (ii) operational value of the forecasts is analysed. Significant operational benefits are obtained.
Background: Rim+ lesions in multiple sclerosis (MS), detectable via Quantitative Susceptibility Mapping (QSM), correlate with increased disability. Existing literature lacks quantitative analysis of these lesions. We introduce RimSet for quantitative identification and characterization of rim+ lesions on QSM. Methods: RimSet combines RimSeg, an unsupervised segmentation method using level-set methodology, and radiomic measurements with Local Binary Pattern texture descriptors. We validated RimSet using simulated QSM images and an in vivo dataset of 172 MS subjects with 177 rim+ and 3986 rim-lesions. Results: RimSeg achieved a 78.7% Dice score against the ground truth, with challenges in partial rim lesions. RimSet detected rim+ lesions with a partial ROC AUC of 0.808 and PR AUC of 0.737, surpassing existing methods. QSMRim-Net showed the lowest mean square error (0.85) and high correlation (0.91; 95% CI: 0.88, 0.93) with expert annotations at the subject level.