Brain Structure-Function Fusing Representation Learning using Adversarial Decomposed-VAE for Analyzing MCI

Integrating the brain structural and functional connectivity features is of great significance in both exploring brain science and analyzing cognitive impairment clinically. However, it remains a challenge to effectively fuse structural and functional features in exploring the brain network. In this paper, a novel brain structure-function fusing-representation learning (BSFL) model is proposed to effectively learn fused representation from diffusion tensor imaging (DTI) and resting-state functional magnetic resonance imaging (fMRI) for mild cognitive impairment (MCI) analysis. Specifically, the decomposition-fusion framework is developed to first decompose the feature space into the union of the uniform and the unique spaces for each modality, and then adaptively fuse the decomposed features to learn MCI-related representation. Moreover, a knowledge-aware transformer module is designed to automatically capture local and global connectivity features throughout the brain. Also, a uniform-unique contrastive loss is further devised to make the decomposition more effective and enhance the complementarity of structural and functional features. The extensive experiments demonstrate that the proposed model achieves better performance than other competitive methods in predicting and analyzing MCI. More importantly, the proposed model could be a potential tool for reconstructing unified brain networks and predicting abnormal connections during the degenerative processes in MCI.

Instruction-ViT: Multi-Modal Prompts for Instruction Learning in ViT

Prompts have been proven to play a crucial role in large language models, and in recent years, vision models have also been using prompts to improve scalability for multiple downstream tasks. In this paper, we focus on adapting prompt design based on instruction tuning into a visual transformer model for image classification which we called Instruction-ViT. The key idea is to implement multi-modal prompts (text or image prompt) related to category information to guide the fine-tuning of the model. Based on the experiments of several image captionining tasks, the performance and domain adaptability were improved. Our work provided an innovative strategy to fuse multi-modal prompts with better performance and faster adaptability for visual classification models.

Multi-modal Multi-kernel Graph Learning for Autism Prediction and Biomarker Discovery

Multi-modal integration and classification based on graph learning is among the most challenging obstacles in disease prediction due to its complexity. Several recent works on the basis of attentional mechanisms have been proposed to disentangle the problem of multi-modal integration. However, there are certain limitations to these techniques. Primarily, these works focus on explicitly integrating at the feature level using weight scores, which cannot effectively address the negative impact between modalities. Next, a majority of them utilize single-sized filters to extract graph features, ignoring the heterogeneous information over graphs. To overcome these drawbacks, we propose MMKGL (Multi-modal Multi-Kernel Graph Learning). For the problem of negative impact between modalities, we use the multi-modal graph embedding module to construct a multi-modal graph. Different from the traditional manual construction of static graphs, a separate graph is generated for each modality by graph adaptive learning, where a function graph and a supervision graph are introduced for optimiztion during the multi-graph fusion embedding process. We then apply the multi-kernel graph learning module to extract heterogeneous information from the multi-modal graph. The information in the multi-modal graph at different levels is aggregated by convolutional kernels with different receptive field sizes, followed by generating a cross-kernel discovery tensor for disease prediction. Our method is evaluated on the benchmark Autism Brain Imaging Data Exchange (ABIDE) dataset and outperforms the state-of-the-art methods. In addition, discriminative brain regions associated with autism are identified by our model, providing guidance for the study of autism pathology.

Meta-data Study in Autism Spectrum Disorder Classification Based on Structural MRI

Accurate diagnosis of autism spectrum disorder (ASD) based on neuroimaging data has significant implications, as extracting useful information from neuroimaging data for ASD detection is challenging. Even though machine learning techniques have been leveraged to improve the information extraction from neuroimaging data, the varying data quality caused by different meta-data conditions (i.e., data collection strategies) limits the effective information that can be extracted, thus leading to data-dependent predictive accuracies in ASD detection, which can be worse than random guess in some cases. In this work, we systematically investigate the impact of three kinds of meta-data on the predictive accuracy of classifying ASD based on structural MRI collected from 20 different sites, where meta-data conditions vary.

Identification of Autism spectrum disorder based on a novel feature selection method and Variational Autoencoder

The development of noninvasive brain imaging such as resting-state functional magnetic resonance imaging (rs-fMRI) and its combination with AI algorithm provides a promising solution for the early diagnosis of Autism spectrum disorder (ASD). However, the performance of the current ASD classification based on rs-fMRI still needs to be improved. This paper introduces a classification framework to aid ASD diagnosis based on rs-fMRI. In the framework, we proposed a novel filter feature selection method based on the difference between step distribution curves (DSDC) to select remarkable functional connectivities (FCs) and utilized a multilayer perceptron (MLP) which was pretrained by a simplified Variational Autoencoder (VAE) for classification. We also designed a pipeline consisting of a normalization procedure and a modified hyperbolic tangent (tanh) activation function to replace the original tanh function, further improving the model accuracy. Our model was evaluated by 10 times 10-fold cross-validation and achieved an average accuracy of 78.12%, outperforming the state-of-the-art methods reported on the same dataset. Given the importance of sensitivity and specificity in disease diagnosis, two constraints were designed in our model which can improve the model's sensitivity and specificity by up to 9.32% and 10.21%, respectively. The added constraints allow our model to handle different application scenarios and can be used broadly.

Generative Adversarial Networks: A Survey Towards Private and Secure Applications

Generative Adversarial Networks (GAN) have promoted a variety of applications in computer vision, natural language processing, etc. due to its generative model's compelling ability to generate realistic examples plausibly drawn from an existing distribution of samples. GAN not only provides impressive performance on data generation-based tasks but also stimulates fertilization for privacy and security oriented research because of its game theoretic optimization strategy. Unfortunately, there are no comprehensive surveys on GAN in privacy and security, which motivates this survey paper to summarize those state-of-the-art works systematically. The existing works are classified into proper categories based on privacy and security functions, and this survey paper conducts a comprehensive analysis of their advantages and drawbacks. Considering that GAN in privacy and security is still at a very initial stage and has imposed unique challenges that are yet to be well addressed, this paper also sheds light on some potential privacy and security applications with GAN and elaborates on some future research directions.

Covid-19 Detection from Chest X-ray and Patient Metadata using Graph Convolutional Neural Networks

The novel corona virus (Covid-19) has introduced significant challenges due to its rapid spreading nature through respiratory transmission. As a result, there is a huge demand for Artificial Intelligence (AI) based quick disease diagnosis methods as an alternative to high demand tests such as Polymerase Chain Reaction (PCR). Chest X-ray (CXR) Image analysis is such cost-effective radiography technique due to resource availability and quick screening. But, a sufficient and systematic data collection that is required by complex deep leaning (DL) models is more difficult and hence there are recent efforts that utilize transfer learning to address this issue. Still these transfer learnt models suffer from lack of generalization and increased bias to the training dataset resulting poor performance for unseen data. Limited correlation of the transferred features from the pre-trained model to a specific medical imaging domain like X-ray and overfitting on fewer data can be reasons for this circumstance. In this work, we propose a novel Graph Convolution Neural Network (GCN) that is capable of identifying bio-markers of Covid-19 pneumonia from CXR images and meta information about patients. The proposed method exploits important relational knowledge between data instances and their features using graph representation and applies convolution to learn the graph data which is not possible with conventional convolution on Euclidean domain. The results of extensive experiments of proposed model on binary (Covid vs normal) and three class (Covid, normal, other pneumonia) classification problems outperform different benchmark transfer learnt models, hence overcoming the aforementioned drawbacks.

Slashing Communication Traffic in Federated Learning by Transmitting Clustered Model Updates

Federated Learning (FL) is an emerging decentralized learning framework through which multiple clients can collaboratively train a learning model. However, a major obstacle that impedes the wide deployment of FL lies in massive communication traffic. To train high dimensional machine learning models (such as CNN models), heavy communication traffic can be incurred by exchanging model updates via the Internet between clients and the parameter server (PS), implying that the network resource can be easily exhausted. Compressing model updates is an effective way to reduce the traffic amount. However, a flexible unbiased compression algorithm applicable for both uplink and downlink compression in FL is still absent from existing works. In this work, we devise the Model Update Compression by Soft Clustering (MUCSC) algorithm to compress model updates transmitted between clients and the PS. In MUCSC, it is only necessary to transmit cluster centroids and the cluster ID of each model update. Moreover, we prove that: 1) The compressed model updates are unbiased estimation of their original values so that the convergence rate by transmitting compressed model updates is unchanged; 2) MUCSC can guarantee that the influence of the compression error on the model accuracy is minimized. Then, we further propose the boosted MUCSC (B-MUCSC) algorithm, a biased compression algorithm that can achieve an extremely high compression rate by grouping insignificant model updates into a super cluster. B-MUCSC is suitable for scenarios with very scarce network resource. Ultimately, we conduct extensive experiments with the CIFAR-10 and FEMNIST datasets to demonstrate that our algorithms can not only substantially reduce the volume of communication traffic in FL, but also improve the training efficiency in practical networks.

Infant Vocal Tract Development Analysis and Diagnosis by Cry Signals with CNN Age Classification

From crying to babbling and then to speech, infant's vocal tract goes through anatomic restructuring. In this paper, we propose a non-invasive fast method of using infant cry signals with convolutional neural network (CNN) based age classification to diagnose the abnormality of the vocal tract development as early as 4-month age. We study F0, F1, F2, and spectrograms and relate them to the postnatal development of infant vocalization. A novel CNN based age classification is performed with binary age pairs to discover the pattern and tendency of the vocal tract changes. The effectiveness of this approach is evaluated on Baby2020 with healthy infant cries and Baby Chillanto database with pathological infant cries. The results show that our approach yields 79.20% accuracy for healthy cries, 84.80% for asphyxiated cries, and 91.20% for deaf cries. Our method first reveals that infants' vocal tract develops to a certain level at 4-month age and infants can start controlling the vocal folds to produce discontinuous cry sounds leading to babbling. Early diagnosis of growth abnormality of the vocal tract can help parents keep vigilant and adopt medical treatment or training therapy for their infants as early as possible.