The conformational landscape of proteins is crucial to understanding their functionality in complex biological processes. Traditional physics-based computational methods, such as molecular dynamics (MD) simulations, suffer from rare event sampling and long equilibration time problems, hindering their applications in general protein systems. Recently, deep generative modeling techniques, especially diffusion models, have been employed to generate novel protein conformations. However, existing score-based diffusion methods cannot properly incorporate important physical prior knowledge to guide the generation process, causing large deviations in the sampled protein conformations from the equilibrium distribution. In this paper, to overcome these limitations, we propose a force-guided SE(3) diffusion model, ConfDiff, for protein conformation generation. By incorporating a force-guided network with a mixture of data-based score models, ConfDiff can can generate protein conformations with rich diversity while preserving high fidelity. Experiments on a variety of protein conformation prediction tasks, including 12 fast-folding proteins and the Bovine Pancreatic Trypsin Inhibitor (BPTI), demonstrate that our method surpasses the state-of-the-art method.
Existing learning-based stereo image codec adopt sophisticated transformation with simple entropy models derived from single image codecs to encode latent representations. However, those entropy models struggle to effectively capture the spatial-disparity characteristics inherent in stereo images, which leads to suboptimal rate-distortion results. In this paper, we propose a stereo image compression framework, named CAMSIC. CAMSIC independently transforms each image to latent representation and employs a powerful decoder-free Transformer entropy model to capture both spatial and disparity dependencies, by introducing a novel content-aware masked image modeling (MIM) technique. Our content-aware MIM facilitates efficient bidirectional interaction between prior information and estimated tokens, which naturally obviates the need for an extra Transformer decoder. Experiments show that our stereo image codec achieves state-of-the-art rate-distortion performance on two stereo image datasets Cityscapes and InStereo2K with fast encoding and decoding speed.
Learned Image Compression (LIC) has achieved dramatic progress regarding objective and subjective metrics. MSE-based models aim to improve objective metrics while generative models are leveraged to improve visual quality measured by subjective metrics. However, they all suffer from blurring or deformation at low bit rates, especially at below $0.2bpp$. Besides, deformation on human faces and text is unacceptable for visual quality assessment, and the problem becomes more prominent on small faces and text. To solve this problem, we combine the advantage of MSE-based models and generative models by utilizing region of interest (ROI). We propose Hierarchical-ROI (H-ROI), to split images into several foreground regions and one background region to improve the reconstruction of regions containing faces, text, and complex textures. Further, we propose adaptive quantization by non-linear mapping within the channel dimension to constrain the bit rate while maintaining the visual quality. Exhaustive experiments demonstrate that our methods achieve better visual quality on small faces and text with lower bit rates, e.g., $0.7X$ bits of HiFiC and $0.5X$ bits of BPG.
To satisfy the rapidly increasing demands on the large image (2K-8K) super-resolution (SR), prevailing methods follow two independent tracks: 1) accelerate existing networks by content-aware routing, and 2) design better super-resolution networks via token mixer refining. Despite directness, they encounter unavoidable defects (e.g., inflexible route or non-discriminative processing) limiting further improvements of quality-complexity trade-off. To erase the drawbacks, we integrate these schemes by proposing a content-aware mixer (CAMixer), which assigns convolution for simple contexts and additional deformable window-attention for sparse textures. Specifically, the CAMixer uses a learnable predictor to generate multiple bootstraps, including offsets for windows warping, a mask for classifying windows, and convolutional attentions for endowing convolution with the dynamic property, which modulates attention to include more useful textures self-adaptively and improves the representation capability of convolution. We further introduce a global classification loss to improve the accuracy of predictors. By simply stacking CAMixers, we obtain CAMixerSR which achieves superior performance on large-image SR, lightweight SR, and omnidirectional-image SR.
Generative adversial network (GAN) is a type of generative model that maps a high-dimensional noise to samples in target distribution. However, the dimension of noise required in GAN is not well understood. Previous approaches view GAN as a mapping from a continuous distribution to another continous distribution. In this paper, we propose to view GAN as a discrete sampler instead. From this perspective, we build a connection between the minimum noise required and the bits to losslessly compress the images. Furthermore, to understand the behaviour of GAN when noise dimension is limited, we propose divergence-entropy trade-off. This trade-off depicts the best divergence we can achieve when noise is limited. And as rate distortion trade-off, it can be numerically solved when source distribution is known. Finally, we verifies our theory with experiments on image generation.
Implicit neural representations (INRs) recently achieved great success in image representation and compression, offering high visual quality and fast rendering speeds with 10-1000 FPS, assuming sufficient GPU resources are available. However, this requirement often hinders their use on low-end devices with limited memory. In response, we propose a groundbreaking paradigm of image representation and compression by 2D Gaussian Splatting, named GaussianImage. We first introduce 2D Gaussian to represent the image, where each Gaussian has 8 parameters including position, covariance and color. Subsequently, we unveil a novel rendering algorithm based on accumulated summation. Remarkably, our method with a minimum of 3$\times$ lower GPU memory usage and 5$\times$ faster fitting time not only rivals INRs (e.g., WIRE, I-NGP) in representation performance, but also delivers a faster rendering speed of 1500-2000 FPS regardless of parameter size. Furthermore, we integrate existing vector quantization technique to build an image codec. Experimental results demonstrate that our codec attains rate-distortion performance comparable to compression-based INRs such as COIN and COIN++, while facilitating decoding speeds of approximately 1000 FPS. Additionally, preliminary proof of concept shows that our codec surpasses COIN and COIN++ in performance when using partial bits-back coding.
Few-shot learning on heterogeneous graphs (FLHG) is attracting more attention from both academia and industry because prevailing studies on heterogeneous graphs often suffer from label sparsity. FLHG aims to tackle the performance degradation in the face of limited annotated data and there have been numerous recent studies proposing various methods and applications. In this paper, we provide a comprehensive review of existing FLHG methods, covering challenges, research progress, and future prospects. Specifically, we first formalize FLHG and categorize its methods into three types: single-heterogeneity FLHG, dual-heterogeneity FLHG, and multi-heterogeneity FLHG. Then, we analyze the research progress within each category, highlighting the most recent and representative developments. Finally, we identify and discuss promising directions for future research in FLHG. To the best of our knowledge, this paper is the first systematic and comprehensive review of FLHG.
Pre-trained diffusion models utilized for image generation encapsulate a substantial reservoir of a priori knowledge pertaining to intricate textures. Harnessing the potential of leveraging this a priori knowledge in the context of image super-resolution presents a compelling avenue. Nonetheless, prevailing diffusion-based methodologies presently overlook the constraints imposed by degradation information on the diffusion process. Furthermore, these methods fail to consider the spatial variability inherent in the estimated blur kernel, stemming from factors such as motion jitter and out-of-focus elements in open-environment scenarios. This oversight results in a notable deviation of the image super-resolution effect from fundamental realities. To address these concerns, we introduce a framework known as Adaptive Multi-modal Fusion of \textbf{S}patially Variant Kernel Refinement with Diffusion Model for Blind Image \textbf{S}uper-\textbf{R}esolution (SSR). Within the SSR framework, we propose a Spatially Variant Kernel Refinement (SVKR) module. SVKR estimates a Depth-Informed Kernel, which takes the depth information into account and is spatially variant. Additionally, SVKR enhance the accuracy of depth information acquired from LR images, allowing for mutual enhancement between the depth map and blur kernel estimates. Finally, we introduce the Adaptive Multi-Modal Fusion (AMF) module to align the information from three modalities: low-resolution images, depth maps, and blur kernels. This alignment can constrain the diffusion model to generate more authentic SR results. Quantitative and qualitative experiments affirm the superiority of our approach, while ablation experiments corroborate the effectiveness of the modules we have proposed.
Implicit neural representations (INRs) have emerged as a promising approach for video storage and processing, showing remarkable versatility across various video tasks. However, existing methods often fail to fully leverage their representation capabilities, primarily due to inadequate alignment of intermediate features during target frame decoding. This paper introduces a universal boosting framework for current implicit video representation approaches. Specifically, we utilize a conditional decoder with a temporal-aware affine transform module, which uses the frame index as a prior condition to effectively align intermediate features with target frames. Besides, we introduce a sinusoidal NeRV-like block to generate diverse intermediate features and achieve a more balanced parameter distribution, thereby enhancing the model's capacity. With a high-frequency information-preserving reconstruction loss, our approach successfully boosts multiple baseline INRs in the reconstruction quality and convergence speed for video regression, and exhibits superior inpainting and interpolation results. Further, we integrate a consistent entropy minimization technique and develop video codecs based on these boosted INRs. Experiments on the UVG dataset confirm that our enhanced codecs significantly outperform baseline INRs and offer competitive rate-distortion performance compared to traditional and learning-based codecs.