Forecasting Parapapillary atrophy (PPA), i.e., a symptom related to most irreversible eye diseases, provides an alarm for implementing an intervention to slow down the disease progression at early stage. A key question for this forecast is: how to fully utilize the historical data (e.g., retinal image) up to the current stage for future disease prediction? In this paper, we provide an answer with a novel framework, namely \textbf{D}isease \textbf{F}orecast via \textbf{P}rogression \textbf{L}earning (\textbf{DFPL}), which exploits the irreversibility prior (i.e., cannot be reversed once diagnosed). Specifically, based on this prior, we decompose two factors that contribute to the prediction of the future disease: i) the current disease label given the data (retinal image, clinical attributes) at present and ii) the future disease label given the progression of the retinal images that from the current to the future. To model these two factors, we introduce the current and progression predictors in DFPL, respectively. In order to account for the degree of progression of the disease, we propose a temporal generative model to accurately generate the future image and compare it with the current one to get a residual image. The generative model is implemented by a recurrent neural network, in order to exploit the dependency of the historical data. To verify our approach, we apply it to a PPA in-house dataset and it yields a significant improvement (\textit{e.g.}, \textbf{4.48\%} of accuracy; \textbf{3.45\%} of AUC) over others. Besides, our generative model can accurately localize the disease-related regions.
Spiking Neural Networks (SNN) have gained increasing attention for its low power consumption. But training SNN is challenging. Liquid State Machine (LSM), as a major type of Reservoir computing, has been widely recognized for its low training cost among SNNs. The exploration of LSM topology for enhancing performance often requires hyper-parameter search, which is both resource-expensive and time-consuming. We explore the influence of input scale reduction on LSM instead. There are two main reasons for studying input reduction of LSM. One is that the input dimension of large images requires efficient processing. Another one is that input exploration is generally more economic than architecture search. To mitigate the difficulty in effectively dealing with huge input spaces of LSM, and to find that whether input reduction can enhance LSM performance, we explore several input patterns, namely fullscale, scanline, chessboard, and patch. Several datasets have been used to evaluate the performance of the proposed input patterns, including two spatio image datasets and one spatio-temporal image database. The experimental results show that the reduced input under chessboard pattern improves the accuracy by up to 5%, and reduces execution time by up to 50% with up to 75\% less input storage than the fullscale input pattern for LSM.