In clinics, a radiology report is crucial for guiding a patient's treatment. Unfortunately, report writing imposes a heavy burden on radiologists. To effectively reduce such a burden, we hereby present an automatic, multi-modal approach for report generation from chest x-ray. Our approach, motivated by the observation that the descriptions in radiology reports are highly correlated with the x-ray images, features two distinct modules: (i) Learned knowledge base. To absorb the knowledge embedded in the above-mentioned correlation, we automatically build a knowledge base based on textual embedding. (ii) Multi-modal alignment. To promote the semantic alignment among reports, disease labels and images, we explicitly utilize textual embedding to guide the learning of the visual feature space. We evaluate the performance of the proposed model using metrics from both natural language generation and clinic efficacy on the public IU and MIMIC-CXR datasets. Our ablation study shows that each module contributes to improving the quality of generated reports. Furthermore, with the aid of both modules, our approach clearly outperforms state-of-the-art methods.
The success of deep learning methods relies on the availability of well-labeled large-scale datasets. However, for medical images, annotating such abundant training data often requires experienced radiologists and consumes their limited time. Few-shot learning is developed to alleviate this burden, which achieves competitive performances with only several labeled data. However, a crucial yet previously overlooked problem in few-shot learning is about the selection of template images for annotation before learning, which affects the final performance. We herein propose a novel Sample Choosing Policy (SCP) to select "the most worthy" images for annotation, in the context of few-shot medical landmark detection. SCP consists of three parts: 1) Self-supervised training for building a pre-trained deep model to extract features from radiological images, 2) Key Point Proposal for localizing informative patches, and 3) Representative Score Estimation for searching the most representative samples or templates. The advantage of SCP is demonstrated by various experiments on three widely-used public datasets. For one-shot medical landmark detection, its use reduces the mean radial errors on Cephalometric and HandXray datasets by 14.2% (from 3.595mm to 3.083mm) and 35.5% (4.114mm to 2.653mm), respectively.
Deep neural network based medical image systems are vulnerable to adversarial examples. Many defense mechanisms have been proposed in the literature, however, the existing defenses assume a passive attacker who knows little about the defense system and does not change the attack strategy according to the defense. Recent works have shown that a strong adaptive attack, where an attacker is assumed to have full knowledge about the defense system, can easily bypass the existing defenses. In this paper, we propose a novel adversarial example defense system called Medical Aegis. To the best of our knowledge, Medical Aegis is the first defense in the literature that successfully addresses the strong adaptive adversarial example attacks to medical images. Medical Aegis boasts two-tier protectors: The first tier of Cushion weakens the adversarial manipulation capability of an attack by removing its high-frequency components, yet posing a minimal effect on classification performance of the original image; the second tier of Shield learns a set of per-class DNN models to predict the logits of the protected model. Deviation from the Shield's prediction indicates adversarial examples. Shield is inspired by the observations in our stress tests that there exist robust trails in the shallow layers of a DNN model, which the adaptive attacks can hardly destruct. Experimental results show that the proposed defense accurately detects adaptive attacks, with negligible overhead for model inference.
While Computed Tomography (CT) reconstruction from X-ray sinograms is necessary for clinical diagnosis, iodine radiation in the imaging process induces irreversible injury, thereby driving researchers to study sparse-view CT reconstruction, that is, recovering a high-quality CT image from a sparse set of sinogram views. Iterative models are proposed to alleviate the appeared artifacts in sparse-view CT images, but the computation cost is too expensive. Then deep-learning-based methods have gained prevalence due to the excellent performances and lower computation. However, these methods ignore the mismatch between the CNN's \textbf{local} feature extraction capability and the sinogram's \textbf{global} characteristics. To overcome the problem, we propose \textbf{Du}al-\textbf{Do}main \textbf{Trans}former (\textbf{DuDoTrans}) to simultaneously restore informative sinograms via the long-range dependency modeling capability of Transformer and reconstruct CT image with both the enhanced and raw sinograms. With such a novel design, reconstruction performance on the NIH-AAPM dataset and COVID-19 dataset experimentally confirms the effectiveness and generalizability of DuDoTrans with fewer involved parameters. Extensive experiments also demonstrate its robustness with different noise-level scenarios for sparse-view CT reconstruction. The code and models are publicly available at https://github.com/DuDoTrans/CODE
Clinical evidence has shown that rib-suppressed chest X-rays (CXRs) can improve the reliability of pulmonary disease diagnosis. However, previous approaches on generating rib-suppressed CXR face challenges in preserving details and eliminating rib residues. We hereby propose a GAN-based disentanglement learning framework called Rib Suppression GAN, or RSGAN, to perform rib suppression by utilizing the anatomical knowledge embedded in unpaired computed tomography (CT) images. In this approach, we employ a residual map to characterize the intensity difference between CXR and the corresponding rib-suppressed result. To predict the residual map in CXR domain, we disentangle the image into structure- and contrast-specific features and transfer the rib structural priors from digitally reconstructed radiographs (DRRs) computed by CT. Furthermore, we employ additional adaptive loss to suppress rib residue and preserve more details. We conduct extensive experiments based on 1,673 CT volumes, and four benchmarking CXR datasets, totaling over 120K images, to demonstrate that (i) our proposed RSGAN achieves superior image quality compared to the state-of-the-art rib suppression methods; (ii) combining CXR with our rib-suppressed result leads to better performance in lung disease classification and tuberculosis area detection.
Accurate polyp segmentation is of great importance for colorectal cancer diagnosis. However, even with a powerful deep neural network, there still exists three big challenges that impede the development of polyp segmentation. (i) Samples collected under different conditions show inconsistent colors, causing the feature distribution gap and overfitting issue; (ii) Due to repeated feature downsampling, small polyps are easily degraded; (iii) Foreground and background pixels are imbalanced, leading to a biased training. To address the above issues, we propose the Shallow Attention Network (SANet) for polyp segmentation. Specifically, to eliminate the effects of color, we design the color exchange operation to decouple the image contents and colors, and force the model to focus more on the target shape and structure. Furthermore, to enhance the segmentation quality of small polyps, we propose the shallow attention module to filter out the background noise of shallow features. Thanks to the high resolution of shallow features, small polyps can be preserved correctly. In addition, to ease the severe pixel imbalance for small polyps, we propose a probability correction strategy (PCS) during the inference phase. Note that even though PCS is not involved in the training phase, it can still work well on a biased model and consistently improve the segmentation performance. Quantitative and qualitative experimental results on five challenging benchmarks confirm that our proposed SANet outperforms previous state-of-the-art methods by a large margin and achieves a speed about 72FPS.
Weakly supervised object localization (WSOL) aims to localize objects by only utilizing image-level labels. Class activation maps (CAMs) are the commonly used features to achieve WSOL. However, previous CAM-based methods did not take full advantage of the shallow features, despite their importance for WSOL. Because shallow features are easily buried in background noise through conventional fusion. In this paper, we propose a simple but effective Shallow feature-aware Pseudo supervised Object Localization (SPOL) model for accurate WSOL, which makes the utmost of low-level features embedded in shallow layers. In practice, our SPOL model first generates the CAMs through a novel element-wise multiplication of shallow and deep feature maps, which filters the background noise and generates sharper boundaries robustly. Besides, we further propose a general class-agnostic segmentation model to achieve the accurate object mask, by only using the initial CAMs as the pseudo label without any extra annotation. Eventually, a bounding box extractor is applied to the object mask to locate the target. Experiments verify that our SPOL outperforms the state-of-the-art on both CUB-200 and ImageNet-1K benchmarks, achieving 93.44% and 67.15% (i.e., 3.93% and 2.13% improvement) Top-5 localization accuracy, respectively.