Target-Independent Domain Adaptation for WBC Classification using Generative Latent Search

Automating the classification of camera-obtained microscopic images of White Blood Cells (WBCs) and related cell subtypes has assumed importance since it aids the laborious manual process of review and diagnosis. Several State-Of-The-Art (SOTA) methods developed using Deep Convolutional Neural Networks suffer from the problem of domain shift - severe performance degradation when they are tested on data (target) obtained in a setting different from that of the training (source). The change in the target data might be caused by factors such as differences in camera/microscope types, lenses, lighting-conditions etc. This problem can potentially be solved using Unsupervised Domain Adaptation (UDA) techniques albeit standard algorithms presuppose the existence of a sufficient amount of unlabelled target data which is not always the case with medical images. In this paper, we propose a method for UDA that is devoid of the need for target data. Given a test image from the target data, we obtain its 'closest-clone' from the source data that is used as a proxy in the classifier. We prove the existence of such a clone given that infinite number of data points can be sampled from the source distribution. We propose a method in which a latent-variable generative model based on variational inference is used to simultaneously sample and find the 'closest-clone' from the source distribution through an optimization procedure in the latent space. We demonstrate the efficacy of the proposed method over several SOTA UDA methods for WBC classification on datasets captured using different imaging modalities under multiple settings.

Guided Weak Supervision for Action Recognition with Scarce Data to Assess Skills of Children with Autism

Diagnostic and intervention methodologies for skill assessment of autism typically requires a clinician repetitively initiating several stimuli and recording the child's response. In this paper, we propose to automate the response measurement through video recording of the scene following the use of Deep Neural models for human action recognition from videos. However, supervised learning of neural networks demand large amounts of annotated data that are hard to come by. This issue is addressed by leveraging the `similarities' between the action categories in publicly available large-scale video action (source) datasets and the dataset of interest. A technique called guided weak supervision is proposed, where every class in the target data is matched to a class in the source data using the principle of posterior likelihood maximization. Subsequently, classifier on the target data is re-trained by augmenting samples from the matched source classes, along with a new loss encouraging inter-class separability. The proposed method is evaluated on two skill assessment autism datasets, SSBD and a real world Autism dataset comprising 37 children of different ages and ethnicity who are diagnosed with autism. Our proposed method is found to improve the performance of the state-of-the-art multi-class human action recognition models in-spite of supervision with scarce data.

NEMGAN: Noise Engineered Mode-matching GAN

Conditional generation refers to the process of sampling from an unknown distribution conditioned on semantics of the data. This can be achieved by augmenting the generative model with the desired semantic labels, albeit it is not straightforward in an unsupervised setting where the semantic label of every data sample is unknown. In this paper, we address this issue by proposing a method that can generate samples conditioned on the properties of a latent distribution engineered in accordance with a certain data prior. In particular, a latent space inversion network is trained in tandem with a generative adversarial network such that the modal properties of the latent space distribution are induced in the data generating distribution. We demonstrate that our model despite being fully unsupervised, is effective in learning meaningful representations through its mode matching property. We validate our method on multiple unsupervised tasks such as conditional generation, attribute discovery and inference using three real world image datasets namely MNIST, CIFAR-10 and CelebA and show that the results are comparable to the state-of-the-art methods.