Domain Adaptation and Transfer Learning in StochasticNets

Transfer learning is a recent field of machine learning research that aims to resolve the challenge of dealing with insufficient training data in the domain of interest. This is a particular issue with traditional deep neural networks where a large amount of training data is needed. Recently, StochasticNets was proposed to take advantage of sparse connectivity in order to decrease the number of parameters that needs to be learned, which in turn may relax training data size requirements. In this paper, we study the efficacy of transfer learning on StochasticNet frameworks. Experimental results show ~7% improvement on StochasticNet performance when the transfer learning is applied in training step.

Efficient Deep Feature Learning and Extraction via StochasticNets

Deep neural networks are a powerful tool for feature learning and extraction given their ability to model high-level abstractions in highly complex data. One area worth exploring in feature learning and extraction using deep neural networks is efficient neural connectivity formation for faster feature learning and extraction. Motivated by findings of stochastic synaptic connectivity formation in the brain as well as the brain's uncanny ability to efficiently represent information, we propose the efficient learning and extraction of features via StochasticNets, where sparsely-connected deep neural networks can be formed via stochastic connectivity between neurons. To evaluate the feasibility of such a deep neural network architecture for feature learning and extraction, we train deep convolutional StochasticNets to learn abstract features using the CIFAR-10 dataset, and extract the learned features from images to perform classification on the SVHN and STL-10 datasets. Experimental results show that features learned using deep convolutional StochasticNets, with fewer neural connections than conventional deep convolutional neural networks, can allow for better or comparable classification accuracy than conventional deep neural networks: relative test error decrease of ~4.5% for classification on the STL-10 dataset and ~1% for classification on the SVHN dataset. Furthermore, it was shown that the deep features extracted using deep convolutional StochasticNets can provide comparable classification accuracy even when only 10% of the training data is used for feature learning. Finally, it was also shown that significant gains in feature extraction speed can be achieved in embedded applications using StochasticNets. As such, StochasticNets allow for faster feature learning and extraction performance while facilitate for better or comparable accuracy performances.

Discovery Radiomics via StochasticNet Sequencers for Cancer Detection

Radiomics has proven to be a powerful prognostic tool for cancer detection, and has previously been applied in lung, breast, prostate, and head-and-neck cancer studies with great success. However, these radiomics-driven methods rely on pre-defined, hand-crafted radiomic feature sets that can limit their ability to characterize unique cancer traits. In this study, we introduce a novel discovery radiomics framework where we directly discover custom radiomic features from the wealth of available medical imaging data. In particular, we leverage novel StochasticNet radiomic sequencers for extracting custom radiomic features tailored for characterizing unique cancer tissue phenotype. Using StochasticNet radiomic sequencers discovered using a wealth of lung CT data, we perform binary classification on 42,340 lung lesions obtained from the CT scans of 93 patients in the LIDC-IDRI dataset. Preliminary results show significant improvement over previous state-of-the-art methods, indicating the potential of the proposed discovery radiomics framework for improving cancer screening and diagnosis.

StochasticNet: Forming Deep Neural Networks via Stochastic Connectivity

Deep neural networks is a branch in machine learning that has seen a meteoric rise in popularity due to its powerful abilities to represent and model high-level abstractions in highly complex data. One area in deep neural networks that is ripe for exploration is neural connectivity formation. A pivotal study on the brain tissue of rats found that synaptic formation for specific functional connectivity in neocortical neural microcircuits can be surprisingly well modeled and predicted as a random formation. Motivated by this intriguing finding, we introduce the concept of StochasticNet, where deep neural networks are formed via stochastic connectivity between neurons. As a result, any type of deep neural networks can be formed as a StochasticNet by allowing the neuron connectivity to be stochastic. Stochastic synaptic formations, in a deep neural network architecture, can allow for efficient utilization of neurons for performing specific tasks. To evaluate the feasibility of such a deep neural network architecture, we train a StochasticNet using four different image datasets (CIFAR-10, MNIST, SVHN, and STL-10). Experimental results show that a StochasticNet, using less than half the number of neural connections as a conventional deep neural network, achieves comparable accuracy and reduces overfitting on the CIFAR-10, MNIST and SVHN dataset. Interestingly, StochasticNet with less than half the number of neural connections, achieved a higher accuracy (relative improvement in test error rate of ~6% compared to ConvNet) on the STL-10 dataset than a conventional deep neural network. Finally, StochasticNets have faster operational speeds while achieving better or similar accuracy performances.

Discovery Radiomics for Multi-Parametric MRI Prostate Cancer Detection

Prostate cancer is the most diagnosed form of cancer in Canadian men, and is the third leading cause of cancer death. Despite these statistics, prognosis is relatively good with a sufficiently early diagnosis, making fast and reliable prostate cancer detection crucial. As imaging-based prostate cancer screening, such as magnetic resonance imaging (MRI), requires an experienced medical professional to extensively review the data and perform a diagnosis, radiomics-driven methods help streamline the process and has the potential to significantly improve diagnostic accuracy and efficiency, and thus improving patient survival rates. These radiomics-driven methods currently rely on hand-crafted sets of quantitative imaging-based features, which are selected manually and can limit their ability to fully characterize unique prostate cancer tumour phenotype. In this study, we propose a novel \textit{discovery radiomics} framework for generating custom radiomic sequences tailored for prostate cancer detection. Discovery radiomics aims to uncover abstract imaging-based features that capture highly unique tumour traits and characteristics beyond what can be captured using predefined feature models. In this paper, we discover new custom radiomic sequencers for generating new prostate radiomic sequences using multi-parametric MRI data. We evaluated the performance of the discovered radiomic sequencer against a state-of-the-art hand-crafted radiomic sequencer for computer-aided prostate cancer detection with a feedforward neural network using real clinical prostate multi-parametric MRI data. Results for the discovered radiomic sequencer demonstrate good performance in prostate cancer detection and clinical decision support relative to the hand-crafted radiomic sequencer. The use of discovery radiomics shows potential for more efficient and reliable automatic prostate cancer detection.

Forming A Random Field via Stochastic Cliques: From Random Graphs to Fully Connected Random Fields

Random fields have remained a topic of great interest over past decades for the purpose of structured inference, especially for problems such as image segmentation. The local nodal interactions commonly used in such models often suffer the short-boundary bias problem, which are tackled primarily through the incorporation of long-range nodal interactions. However, the issue of computational tractability becomes a significant issue when incorporating such long-range nodal interactions, particularly when a large number of long-range nodal interactions (e.g., fully-connected random fields) are modeled. In this work, we introduce a generalized random field framework based around the concept of stochastic cliques, which addresses the issue of computational tractability when using fully-connected random fields by stochastically forming a sparse representation of the random field. The proposed framework allows for efficient structured inference using fully-connected random fields without any restrictions on the potential functions that can be utilized. Several realizations of the proposed framework using graph cuts are presented and evaluated, and experimental results demonstrate that the proposed framework can provide competitive performance for the purpose of image segmentation when compared to existing fully-connected and principled deep random field frameworks.

A deep-structured fully-connected random field model for structured inference

There has been significant interest in the use of fully-connected graphical models and deep-structured graphical models for the purpose of structured inference. However, fully-connected and deep-structured graphical models have been largely explored independently, leaving the unification of these two concepts ripe for exploration. A fundamental challenge with unifying these two types of models is in dealing with computational complexity. In this study, we investigate the feasibility of unifying fully-connected and deep-structured models in a computationally tractable manner for the purpose of structured inference. To accomplish this, we introduce a deep-structured fully-connected random field (DFRF) model that integrates a series of intermediate sparse auto-encoding layers placed between state layers to significantly reduce computational complexity. The problem of image segmentation was used to illustrate the feasibility of using the DFRF for structured inference in a computationally tractable manner. Results in this study show that it is feasible to unify fully-connected and deep-structured models in a computationally tractable manner for solving structured inference problems such as image segmentation.