A reliable Ultrasound (US)-to-US registration method to compensate for brain shift would substantially improve Image-Guided Neurological Surgery. Developing such a registration method is very challenging, due to factors such as missing correspondence in images, the complexity of brain pathology and the demand for fast computation. We propose a novel feature-driven active framework. Here, landmarks and their displacement are first estimated from a pair of US images using corresponding local image features. Subsequently, a Gaussian Process (GP) model is used to interpolate a dense deformation field from the sparse landmarks. Kernels of the GP are estimated by using variograms and a discrete grid search method. If necessary, the user can actively add new landmarks based on the image context and visualization of the uncertainty measure provided by the GP to further improve the result. We retrospectively demonstrate our registration framework as a robust and accurate brain shift compensation solution on clinical data acquired during neurosurgery.
A matrix completion problem, which aims to recover a complete matrix from its partial observations, is one of the important problems in the machine learning field and has been studied actively. However, there is a discrepancy between the mainstream problem setting, which assumes continuous-valued observations, and some practical applications such as recommendation systems and SNS link predictions where observations take discrete or even binary values. To cope with this problem, Davenport et al. (2014) proposed a binary matrix completion (BMC) problem, where observations are quantized into binary values. Hsieh et al. (2015) proposed a PU (Positive and Unlabeled) matrix completion problem, which is an extension of the BMC problem. This problem targets the setting where we cannot observe negative values, such as SNS link predictions. In the construction of their method for this setting, they introduced a methodology of the classification problem, regarding each matrix entry as a sample. Their risk, which defines losses over unobserved entries as well, indicates the possibility of the use of unobserved entries. In this paper, motivated by a semi-supervised classification method recently proposed by Sakai et al. (2017), we develop a method for the BMC problem which can use all of positive, negative, and unobserved entries, by combining the risks of Davenport et al. (2014) and Hsieh et al. (2015). To the best of our knowledge, this is the first BMC method which exploits all kinds of matrix entries. We experimentally show that an appropriate mixture of risks improves the performance.
We present the first framework for Gaussian-process-modulated Poisson processes when the temporal data appear in the form of panel counts. Panel count data frequently arise when experimental subjects are observed only at discrete time points and only the numbers of occurrences of the events between subsequent observation times are available. The exact occurrence timestamps of the events are unknown. The method of conducting the efficient variational inference is presented, based on the assumption of a Gaussian-process-modulated intensity function. We derive a tractable lower bound to alleviate the problems of the intractable evidence lower bound inherent in the variational inference framework. Our algorithm outperforms classical methods on both synthetic and three real panel count sets.
Robustness to outliers is a central issue in real-world machine learning applications. While replacing a model to a heavy-tailed one (e.g., from Gaussian to Student-t) is a standard approach for robustification, it can only be applied to simple models. In this paper, based on Zellner's optimization and variational formulation of Bayesian inference, we propose an outlier-robust pseudo-Bayesian variational method by replacing the Kullback-Leibler divergence used for data fitting to a robust divergence such as the beta- and gamma-divergences. An advantage of our approach is that superior but complex models such as deep networks can also be handled. We theoretically prove that, for deep networks with ReLU activation functions, the \emph{influence function} in our proposed method is bounded, while it is unbounded in the ordinary variational inference. This implies that our proposed method is robust to both of input and output outliers, while the ordinary variational method is not. We experimentally demonstrate that our robust variational method outperforms ordinary variational inference in regression and classification with deep networks.
Actor-critic methods solve reinforcement learning problems by updating a parameterized policy known as an actor in a direction that increases an estimate of the expected return known as a critic. However, existing actor-critic methods only use values or gradients of the critic to update the policy parameter. In this paper, we propose a novel actor-critic method called the guide actor-critic (GAC). GAC firstly learns a guide actor that locally maximizes the critic and then it updates the policy parameter based on the guide actor by supervised learning. Our main theoretical contributions are two folds. First, we show that GAC updates the guide actor by performing second-order optimization in the action space where the curvature matrix is based on the Hessians of the critic. Second, we show that the deterministic policy gradient method is a special case of GAC when the Hessians are ignored. Through experiments, we show that our method is a promising reinforcement learning method for continuous controls.
Recent advances in weakly supervised classification allow us to train a classifier only from positive and unlabeled (PU) data. However, existing PU classification methods typically require an accurate estimate of the class-prior probability, which is a critical bottleneck particularly for high-dimensional data. This problem has been commonly addressed by applying principal component analysis in advance, but such unsupervised dimension reduction can collapse underlying class structure. In this paper, we propose a novel representation learning method from PU data based on the information-maximization principle. Our method does not require class-prior estimation and thus can be used as a preprocessing method for PU classification. Through experiments, we demonstrate that our method combined with deep neural networks highly improves the accuracy of PU class-prior estimation, leading to state-of-the-art PU classification performance.
Learning using privileged information is an attractive problem setting that helps many learning scenarios in the real world. A state-of-the-art method of Gaussian process classification (GPC) with privileged information is GPC+, which incorporates privileged information into a noise term of the likelihood. A drawback of GPC+ is that it requires numerical quadrature to calculate the posterior distribution of the latent function, which is extremely time-consuming. To overcome this limitation, we propose a novel classification method with privileged information based on Gaussian processes, called "soft-label-transferred Gaussian process (SLT-GP)." Our basic idea is that we construct another learning task of predicting soft labels (continuous values) obtained from privileged information and we perform transfer learning from this task to the target task of predicting hard labels. We derive a PAC-Bayesian bound of our proposed method, which justifies optimizing hyperparameters by the empirical Bayes method. We also experimentally show the usefulness of our proposed method compared with GPC and GPC+.
Reducing labeling costs in supervised learning is a critical issue in many practical machine learning applications. In this paper, we consider positive-confidence (Pconf) classification, the problem of training a binary classifier only from positive data equipped with confidence. Pconf classification can be regarded as a discriminative extension of one-class classification (which is aimed at "describing" the positive class by clustering-related methods), with ability to tune hyper-parameters for "classifying" positive and negative samples. Pconf classification is also related to positive-unlabeled (PU) classification (which uses hard-labeled positive data and unlabeled data), but the difference is that it enables us to avoid estimating the class priors, which is a critical bottleneck in typical PU classification methods. For the Pconf classification problem, we provide a simple empirical risk minimization framework and give a formulation for linear-in-parameter models that can be implemented easily and computationally efficiently. We also theoretically establish the consistency and estimation error bound for Pconf classification, and demonstrate the practical usefulness of the proposed method for deep neural networks through experiments.
We consider a novel stochastic multi-armed bandit problem called {\em good arm identification} (GAI), where a good arm is defined as an arm with expected reward greater than or equal to a given threshold. GAI is a pure-exploration problem that a single agent repeats a process of outputting an arm as soon as it is identified as a good one before confirming the other arms are actually not good. The objective of GAI is to minimize the number of samples for each process. We find that GAI faces a new kind of dilemma, the {\em exploration-exploitation dilemma of confidence}, which is different difficulty from the best arm identification. As a result, an efficient design of algorithms for GAI is quite different from that for the best arm identification. We derive a lower bound on the sample complexity of GAI that is tight up to the logarithmic factor $\mathrm{O}(\log \frac{1}{\delta})$ for acceptance error rate $\delta$. We also develop an algorithm whose sample complexity almost matches the lower bound. We also confirm experimentally that our proposed algorithm outperforms naive algorithms in synthetic settings based on a conventional bandit problem and clinical trial researches for rheumatoid arthritis.
In ranking problems, the goal is to learn a ranking function from labeled pairs of input points. In this paper, we consider the related comparison problem, where the label indicates which element of the pair is better, or if there is no significant difference. We cast the learning problem as a margin maximization, and show that it can be solved by converting it to a standard SVM. We use simulated nonlinear patterns, a real learning to rank sushi data set, and a chess data set to show that our proposed SVMcompare algorithm outperforms SVMrank when there are equality pairs.