Recently, diffusion-based methods for monocular 3D human pose estimation have achieved state-of-the-art (SOTA) performance by directly regressing the 3D joint coordinates from the 2D pose sequence. Although some methods decompose the task into bone length and bone direction prediction based on the human anatomical skeleton to explicitly incorporate more human body prior constraints, the performance of these methods is significantly lower than that of the SOTA diffusion-based methods. This can be attributed to the tree structure of the human skeleton. Direct application of the disentangled method could amplify the accumulation of hierarchical errors, propagating through each hierarchy. Meanwhile, the hierarchical information has not been fully explored by the previous methods. To address these problems, a Disentangled Diffusion-based 3D Human Pose Estimation method with Hierarchical Spatial and Temporal Denoiser is proposed, termed DDHPose. In our approach: (1) We disentangle the 3D pose and diffuse the bone length and bone direction during the forward process of the diffusion model to effectively model the human pose prior. A disentanglement loss is proposed to supervise diffusion model learning. (2) For the reverse process, we propose Hierarchical Spatial and Temporal Denoiser (HSTDenoiser) to improve the hierarchical modeling of each joint. Our HSTDenoiser comprises two components: the Hierarchical-Related Spatial Transformer (HRST) and the Hierarchical-Related Temporal Transformer (HRTT). HRST exploits joint spatial information and the influence of the parent joint on each joint for spatial modeling, while HRTT utilizes information from both the joint and its hierarchical adjacent joints to explore the hierarchical temporal correlations among joints.
Recent work found high mutual information between the learned representations of large language models (LLMs) and the geospatial property of its input, hinting an emergent internal model of space. However, whether this internal space model has any causal effects on the LLMs' behaviors was not answered by that work, led to criticism of these findings as mere statistical correlation. Our study focused on uncovering the causality of the spatial representations in LLMs. In particular, we discovered the potential spatial representations in DeBERTa, GPT-Neo using representational similarity analysis and linear and non-linear probing. Our casual intervention experiments showed that the spatial representations influenced the model's performance on next word prediction and a downstream task that relies on geospatial information. Our experiments suggested that the LLMs learn and use an internal model of space in solving geospatial related tasks.
Ample evidence suggests that better machine learning models may be steadily obtained by training on increasingly larger datasets on natural language processing (NLP) problems from non-medical domains. Whether the same holds true for medical NLP has by far not been thoroughly investigated. This work shows that this is indeed not always the case. We reveal the somehow counter-intuitive observation that performant medical NLP models may be obtained with small amount of labeled data, quite the opposite to the common belief, most likely due to the domain specificity of the problem. We show quantitatively the effect of training data size on a fixed test set composed of two of the largest public chest x-ray radiology report datasets on the task of abnormality classification. The trained models not only make use of the training data efficiently, but also outperform the current state-of-the-art rule-based systems by a significant margin.
Bootstrapping labels from radiology reports has become the scalable alternative to provide inexpensive ground truth for medical imaging. Because of the domain specific nature, state-of-the-art report labeling tools are predominantly rule-based. These tools, however, typically yield a binary 0 or 1 prediction that indicates the presence or absence of abnormalities. These hard targets are then used as ground truth to train image models in the downstream, forcing models to express high degree of certainty even on cases where specificity is low. This could negatively impact the statistical efficiency of image models. We address such an issue by training a Bidirectional Long-Short Term Memory Network to augment heuristic-based discrete labels of X-ray reports from all body regions and achieve performance comparable or better than domain-specific NLP, but with additional uncertainty estimates which enable finer downstream image model training.
Acquiring high-quality annotations in medical imaging is usually a costly process. Automatic label extraction with natural language processing (NLP) has emerged as a promising workaround to bypass the need of expert annotation. Despite the convenience, the limitation of such an approximation has not been carefully examined and is not well understood. With a challenging set of 1,000 chest X-ray studies and their corresponding radiology reports, we show that there exists a surprisingly large discrepancy between what radiologists visually perceive and what they clinically report. Furthermore, with inherently flawed report as ground truth, the state-of-the-art medical NLP fails to produce high-fidelity labels.
This work provides a strong baseline for the problem of multi-source multi-target domain adaptation and generalization in medical imaging. Using a diverse collection of ten chest X-ray datasets, we empirically demonstrate the benefits of training medical imaging deep learning models on varied patient populations for generalization to out-of-sample domains.
Obtaining datasets labeled to facilitate model development is a challenge for most machine learning tasks. The difficulty is heightened for medical imaging, where data itself is limited in accessibility and labeling requires costly time and effort by trained medical specialists. Medical imaging studies, however, are often accompanied by a medical report produced by a radiologist, identifying important features on the corresponding scan for other physicians not specifically trained in radiology. We propose a methodology for approximating image-level labels for radiology studies from associated reports using a general purpose language processing tool for medical concept extraction and sentiment analysis, and simple manually crafted heuristics for false positive reduction. Using this approach, we label more than 175,000 Head CT studies for the presence of 33 features indicative of 11 clinically relevant conditions. For 27 of the 30 keywords that yielded positive results (3 had no occurrences), the lower bound of the confidence intervals created to estimate the percentage of accurately labeled reports was above 85%, with the average being above 95%. Though noisier then manual labeling, these results suggest this method to be a viable means of labeling medical images at scale.
Diagnostic imaging often requires the simultaneous identification of a multitude of findings of varied size and appearance. Beyond global indication of said findings, the prediction and display of localization information improves trust in and understanding of results when augmenting clinical workflow. Medical training data rarely includes more than global image-level labels as segmentations are time-consuming and expensive to collect. We introduce an approach to managing these practical constraints by applying a novel architecture which learns at multiple resolutions while generating saliency maps with weak supervision. Further, we parameterize the Log-Sum-Exp pooling function with a learnable lower-bounded adaptation (LSE-LBA) to build in a sharpness prior and better handle localizing abnormalities of different sizes using only image-level labels. Applying this approach to interpreting chest x-rays, we set the state of the art on 9 abnormalities in the NIH's CXR14 dataset while generating saliency maps with the highest resolution to date.
The field of medical diagnostics contains a wealth of challenges which closely resemble classical machine learning problems; practical constraints, however, complicate the translation of these endpoints naively into classical architectures. Many tasks in radiology, for example, are largely problems of multi-label classification wherein medical images are interpreted to indicate multiple present or suspected pathologies. Clinical settings drive the necessity for high accuracy simultaneously across a multitude of pathological outcomes and greatly limit the utility of tools which consider only a subset. This issue is exacerbated by a general scarcity of training data and maximizes the need to extract clinically relevant features from available samples -- ideally without the use of pre-trained models which may carry forward undesirable biases from tangentially related tasks. We present and evaluate a partial solution to these constraints in using LSTMs to leverage interdependencies among target labels in predicting 14 pathologic patterns from chest x-rays and establish state of the art results on the largest publicly available chest x-ray dataset from the NIH without pre-training. Furthermore, we propose and discuss alternative evaluation metrics and their relevance in clinical practice.
The task of associating images and videos with a natural language description has attracted a great amount of attention recently. Rapid progress has been made in terms of both developing novel algorithms and releasing new datasets. Indeed, the state-of-the-art results on some of the standard datasets have been pushed into the regime where it has become more and more difficult to make significant improvements. Instead of proposing new models, this work investigates the possibility of empirically establishing performance upper bounds on various visual captioning datasets without extra data labelling effort or human evaluation. In particular, it is assumed that visual captioning is decomposed into two steps: from visual inputs to visual concepts, and from visual concepts to natural language descriptions. One would be able to obtain an upper bound when assuming the first step is perfect and only requiring training a conditional language model for the second step. We demonstrate the construction of such bounds on MS-COCO, YouTube2Text and LSMDC (a combination of M-VAD and MPII-MD). Surprisingly, despite of the imperfect process we used for visual concept extraction in the first step and the simplicity of the language model for the second step, we show that current state-of-the-art models fall short when being compared with the learned upper bounds. Furthermore, with such a bound, we quantify several important factors concerning image and video captioning: the number of visual concepts captured by different models, the trade-off between the amount of visual elements captured and their accuracy, and the intrinsic difficulty and blessing of different datasets.