Safe motion planning for robotic systems in dynamic environments is nontrivial in the presence of uncertain obstacles, where estimation of obstacle uncertainties is crucial in predicting future motions of dynamic obstacles. The worst-case characterization gives a conservative uncertainty prediction and may result in infeasible motion planning for the ego robotic system. In this paper, an efficient, robust, and safe motion-planing algorithm is developed by learning the obstacle uncertainties online. More specifically, the unknown yet intended control set of obstacles is efficiently computed by solving a linear programming problem. The learned control set is used to compute forward reachable sets of obstacles that are less conservative than the worst-case prediction. Based on the forward prediction, a robust model predictive controller is designed to compute a safe reference trajectory for the ego robotic system that remains outside the reachable sets of obstacles over the prediction horizon. The method is applied to a car-like mobile robot in both simulations and hardware experiments to demonstrate its effectiveness.
Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal cancer in which the tumor-vascular involvement greatly affects the resectability and, thus, overall survival of patients. However, current prognostic prediction methods fail to explicitly and accurately investigate relationships between the tumor and nearby important vessels. This paper proposes a novel learnable neural distance that describes the precise relationship between the tumor and vessels in CT images of different patients, adopting it as a major feature for prognosis prediction. Besides, different from existing models that used CNNs or LSTMs to exploit tumor enhancement patterns on dynamic contrast-enhanced CT imaging, we improved the extraction of dynamic tumor-related texture features in multi-phase contrast-enhanced CT by fusing local and global features using CNN and transformer modules, further enhancing the features extracted across multi-phase CT images. We extensively evaluated and compared the proposed method with existing methods in the multi-center (n=4) dataset with 1,070 patients with PDAC, and statistical analysis confirmed its clinical effectiveness in the external test set consisting of three centers. The developed risk marker was the strongest predictor of overall survival among preoperative factors and it has the potential to be combined with established clinical factors to select patients at higher risk who might benefit from neoadjuvant therapy.
Objective: The artificial pancreas (AP) has shown promising potential in achieving closed-loop glucose control for individuals with type 1 diabetes mellitus (T1DM). However, designing an effective control policy for the AP remains challenging due to the complex physiological processes, delayed insulin response, and inaccurate glucose measurements. While model predictive control (MPC) offers safety and stability through the dynamic model and safety constraints, it lacks individualization and is adversely affected by unannounced meals. Conversely, deep reinforcement learning (DRL) provides personalized and adaptive strategies but faces challenges with distribution shifts and substantial data requirements. Methods: We propose a hybrid control policy for the artificial pancreas (HyCPAP) to address the above challenges. HyCPAP combines an MPC policy with an ensemble DRL policy, leveraging the strengths of both policies while compensating for their respective limitations. To facilitate faster deployment of AP systems in real-world settings, we further incorporate meta-learning techniques into HyCPAP, leveraging previous experience and patient-shared knowledge to enable fast adaptation to new patients with limited available data. Results: We conduct extensive experiments using the FDA-accepted UVA/Padova T1DM simulator across three scenarios. Our approaches achieve the highest percentage of time spent in the desired euglycemic range and the lowest occurrences of hypoglycemia. Conclusion: The results clearly demonstrate the superiority of our methods for closed-loop glucose management in individuals with T1DM. Significance: The study presents novel control policies for AP systems, affirming the great potential of proposed methods for efficient closed-loop glucose control.
Designing biological sequences is an important challenge that requires satisfying complex constraints and thus is a natural problem to address with deep generative modeling. Diffusion generative models have achieved considerable success in many applications. Score-based generative stochastic differential equations (SDE) model is a continuous-time diffusion model framework that enjoys many benefits, but the originally proposed SDEs are not naturally designed for modeling discrete data. To develop generative SDE models for discrete data such as biological sequences, here we introduce a diffusion process defined in the probability simplex space with stationary distribution being the Dirichlet distribution. This makes diffusion in continuous space natural for modeling discrete data. We refer to this approach as Dirchlet diffusion score model. We demonstrate that this technique can generate samples that satisfy hard constraints using a Sudoku generation task. This generative model can also solve Sudoku, including hard puzzles, without additional training. Finally, we applied this approach to develop the first human promoter DNA sequence design model and showed that designed sequences share similar properties with natural promoter sequences.
Limited availability of representative time-to-failure (TTF) trajectories either limits the performance of deep learning (DL)-based approaches on remaining useful life (RUL) prediction in practice or even precludes their application. Generating synthetic data that is physically plausible is a promising way to tackle this challenge. In this study, a novel hybrid framework combining the controlled physics-informed data generation approach with a deep learning-based prediction model for prognostics is proposed. In the proposed framework, a new controlled physics-informed generative adversarial network (CPI-GAN) is developed to generate synthetic degradation trajectories that are physically interpretable and diverse. Five basic physics constraints are proposed as the controllable settings in the generator. A physics-informed loss function with penalty is designed as the regularization term, which ensures that the changing trend of system health state recorded in the synthetic data is consistent with the underlying physical laws. Then, the generated synthetic data is used as input of the DL-based prediction model to obtain the RUL estimations. The proposed framework is evaluated based on new Commercial Modular Aero-Propulsion System Simulation (N-CMAPSS), a turbofan engine prognostics dataset where a limited avail-ability of TTF trajectories is assumed. The experimental results demonstrate that the proposed framework is able to generate synthetic TTF trajectories that are consistent with underlying degradation trends. The generated trajectories enable to significantly improve the accuracy of RUL predictions.
Spectral computed tomography (CT) has recently emerged as an advanced version of medical CT and significantly improves conventional (single-energy) CT. Spectral CT has two main forms: dual-energy computed tomography (DECT) and photon-counting computed tomography (PCCT), which offer image improvement, material decomposition, and feature quantification relative to conventional CT. However, the inherent challenges of spectral CT, evidenced by data and image artifacts, remain a bottleneck for clinical applications. To address these problems, machine learning techniques have been widely applied to spectral CT. In this review, we present the state-of-the-art data-driven techniques for spectral CT.
We study the problem of semantic segmentation of large-scale 3D point clouds. In recent years, significant research efforts have been directed toward local feature aggregation, improved loss functions and sampling strategies. While the fundamental framework of point cloud semantic segmentation has been largely overlooked, with most existing approaches rely on the U-Net architecture by default. In this paper, we propose U-Next, a small but mighty framework designed for point cloud semantic segmentation. The key to this framework is to learn multi-scale hierarchical representations from semantically similar feature maps. Specifically, we build our U-Next by stacking multiple U-Net $L^1$ codecs in a nested and densely arranged manner to minimize the semantic gap, while simultaneously fusing the feature maps across scales to effectively recover the fine-grained details. We also devised a multi-level deep supervision mechanism to further smooth gradient propagation and facilitate network optimization. Extensive experiments conducted on three large-scale benchmarks including S3DIS, Toronto3D, and SensatUrban demonstrate the superiority and the effectiveness of the proposed U-Next architecture. Our U-Next architecture shows consistent and visible performance improvements across different tasks and baseline models, indicating its great potential to serve as a general framework for future research.
Human readers or radiologists routinely perform full-body multi-organ multi-disease detection and diagnosis in clinical practice, while most medical AI systems are built to focus on single organs with a narrow list of a few diseases. This might severely limit AI's clinical adoption. A certain number of AI models need to be assembled non-trivially to match the diagnostic process of a human reading a CT scan. In this paper, we construct a Unified Tumor Transformer (UniT) model to detect (tumor existence and location) and diagnose (tumor characteristics) eight major cancer-prevalent organs in CT scans. UniT is a query-based Mask Transformer model with the output of multi-organ and multi-tumor semantic segmentation. We decouple the object queries into organ queries, detection queries and diagnosis queries, and further establish hierarchical relationships among the three groups. This clinically-inspired architecture effectively assists inter- and intra-organ representation learning of tumors and facilitates the resolution of these complex, anatomically related multi-organ cancer image reading tasks. UniT is trained end-to-end using a curated large-scale CT images of 10,042 patients including eight major types of cancers and occurring non-cancer tumors (all are pathology-confirmed with 3D tumor masks annotated by radiologists). On the test set of 631 patients, UniT has demonstrated strong performance under a set of clinically relevant evaluation metrics, substantially outperforming both multi-organ segmentation methods and an assembly of eight single-organ expert models in tumor detection, segmentation, and diagnosis. Such a unified multi-cancer image reading model (UniT) can significantly reduce the number of false positives produced by combined multi-system models. This moves one step closer towards a universal high-performance cancer screening tool.
Recognition of facial expression is a challenge when it comes to computer vision. The primary reasons are class imbalance due to data collection and uncertainty due to inherent noise such as fuzzy facial expressions and inconsistent labels. However, current research has focused either on the problem of class imbalance or on the problem of uncertainty, ignoring the intersection of how to address these two problems. Therefore, in this paper, we propose a framework based on Resnet and Attention to solve the above problems. We design weight for each class. Through the penalty mechanism, our model will pay more attention to the learning of small samples during training, and the resulting decrease in model accuracy can be improved by a Convolutional Block Attention Module (CBAM). Meanwhile, our backbone network will also learn an uncertain feature for each sample. By mixing uncertain features between samples, the model can better learn those features that can be used for classification, thus suppressing uncertainty. Experiments show that our method surpasses most basic methods in terms of accuracy on facial expression data sets (e.g., AffectNet, RAF-DB), and it also solves the problem of class imbalance well.