Quantitative Susceptibility Mapping (QSM) dipole inversion is an ill-posed inverse problem for quantifying magnetic susceptibility distributions from MRI tissue phases. While supervised deep learning methods have shown success in specific QSM tasks, their generalizability across different acquisition scenarios remains constrained. Recent developments in diffusion models have demonstrated potential for solving 2D medical imaging inverse problems. However, their application to 3D modalities, such as QSM, remains challenging due to high computational demands. In this work, we developed a 3D image patch-based diffusion model, namely QSMDiff, for robust QSM reconstruction across different scan parameters, alongside simultaneous super-resolution and image-denoising tasks. QSMDiff adopts unsupervised 3D image patch training and full-size measurement guidance during inference for controlled image generation. Evaluation on simulated and in-vivo human brains, using gradient-echo and echo-planar imaging sequences across different acquisition parameters, demonstrates superior performance. The method proposed in QSMDiff also holds promise for impacting other 3D medical imaging applications beyond QSM.
Semantic image synthesis aims to generate high-quality images given semantic conditions, i.e. segmentation masks and style reference images. Existing methods widely adopt generative adversarial networks (GANs). GANs take all conditional inputs and directly synthesize images in a single forward step. In this paper, semantic image synthesis is treated as an image denoising task and is handled with a novel image-to-image diffusion model (IIDM). Specifically, the style reference is first contaminated with random noise and then progressively denoised by IIDM, guided by segmentation masks. Moreover, three techniques, refinement, color-transfer and model ensembles, are proposed to further boost the generation quality. They are plug-in inference modules and do not require additional training. Extensive experiments show that our IIDM outperforms existing state-of-the-art methods by clear margins. Further analysis is provided via detailed demonstrations. We have implemented IIDM based on the Jittor framework; code is available at https://github.com/ader47/jittor-jieke-semantic_images_synthesis.
The consumption of high doses of marijuana can have significant psychological and social impacts. In this study, we propose an interpretable novel framework called the HOGAB (High-Order Graph Attention Neural Networks) model for addictive Marijuana classification and analysis of the localized network clusters that demonstrated abnormal brain activities among chronic marijuana users. The HOGAB integrates dynamic intrinsic functional networks with LSTM technology to capture temporal patterns in fMRI time series of marijuana users. We employed the high-order attention module in neighborhood nodes for information fusion and message passing, enhancing community clustering analysis for long-term marijuana users. Furthermore, we improve the overall classification ability of the model by incorporating attention mechanisms, achieving an AUC of 85.1% and an accuracy of 80.7% in classification, higher than the comparison algoirthms. Specifically, we identified the most relevant subnetworks and cognitive regions that are influenced by persistent marijuana usage, revealing that chronic marijuana consumption adversely affects cognitive control, particularly within the Dorsal Attention and Frontoparietal networks, which are essential for attentional, cognitive and higher cognitive functions. The results show that our proposed model is capable of accurately predicting craving bahavior and identifying brain maps associated with long-term cravings, and thus pinpointing brain regions that are important for analysis.
Chronic diseases such as diabetes are the leading causes of morbidity and mortality worldwide. Numerous research studies have been attempted with various deep learning models in diagnosis. However, most previous studies had certain limitations, including using publicly available datasets (e.g. MIMIC), and imbalanced data. In this study, we collected five-year electronic health records (EHRs) from the Taiwan hospital database, including 1,420,596 clinical notes, 387,392 laboratory test results, and more than 1,505 laboratory test items, focusing on research pre-training large language models. We proposed a novel Large Language Multimodal Models (LLMMs) framework incorporating multimodal data from clinical notes and laboratory test results for the prediction of chronic disease risk. Our method combined a text embedding encoder and multi-head attention layer to learn laboratory test values, utilizing a deep neural network (DNN) module to merge blood features with chronic disease semantics into a latent space. In our experiments, we observe that clinicalBERT and PubMed-BERT, when combined with attention fusion, can achieve an accuracy of 73% in multiclass chronic diseases and diabetes prediction. By transforming laboratory test values into textual descriptions and employing the Flan T-5 model, we achieved a 76% Area Under the ROC Curve (AUROC), demonstrating the effectiveness of leveraging numerical text data for training and inference in language models. This approach significantly improves the accuracy of early-stage diabetes prediction.
Large language models (LLMs) such as ChatGPT have exhibited remarkable performance in generating human-like texts. However, machine-generated texts (MGTs) may carry critical risks, such as plagiarism issues, misleading information, or hallucination issues. Therefore, it is very urgent and important to detect MGTs in many situations. Unfortunately, it is challenging to distinguish MGTs and human-written texts because the distributional discrepancy between them is often very subtle due to the remarkable performance of LLMs. In this paper, we seek to exploit \textit{maximum mean discrepancy} (MMD) to address this issue in the sense that MMD can well identify distributional discrepancies. However, directly training a detector with MMD using diverse MGTs will incur a significantly increased variance of MMD since MGTs may contain \textit{multiple text populations} due to various LLMs. This will severely impair MMD's ability to measure the difference between two samples. To tackle this, we propose a novel \textit{multi-population} aware optimization method for MMD called MMD-MP, which can \textit{avoid variance increases} and thus improve the stability to measure the distributional discrepancy. Relying on MMD-MP, we develop two methods for paragraph-based and sentence-based detection, respectively. Extensive experiments on various LLMs, \eg, GPT2 and ChatGPT, show superior detection performance of our MMD-MP. The source code is available at \url{https://github.com/ZSHsh98/MMD-MP}.
Image customization has been extensively studied in text-to-image (T2I) diffusion models, leading to impressive outcomes and applications. With the emergence of text-to-video (T2V) diffusion models, its temporal counterpart, motion customization, has not yet been well investigated. To address the challenge of one-shot motion customization, we propose Customize-A-Video that models the motion from a single reference video and adapting it to new subjects and scenes with both spatial and temporal varieties. It leverages low-rank adaptation (LoRA) on temporal attention layers to tailor the pre-trained T2V diffusion model for specific motion modeling from the reference videos. To disentangle the spatial and temporal information during the training pipeline, we introduce a novel concept of appearance absorbers that detach the original appearance from the single reference video prior to motion learning. Our proposed method can be easily extended to various downstream tasks, including custom video generation and editing, video appearance customization, and multiple motion combination, in a plug-and-play fashion. Our project page can be found at https://anonymous-314.github.io.
The vulnerability of automated fingerprint recognition systems (AFRSs) to presentation attacks (PAs) promotes the vigorous development of PA detection (PAD) technology. However, PAD methods have been limited by information loss and poor generalization ability, resulting in new PA materials and fingerprint sensors. This paper thus proposes a global-local model-based PAD (RTK-PAD) method to overcome those limitations to some extent. The proposed method consists of three modules, called: 1) the global module; 2) the local module; and 3) the rethinking module. By adopting the cut-out-based global module, a global spoofness score predicted from nonlocal features of the entire fingerprint images can be achieved. While by using the texture in-painting-based local module, a local spoofness score predicted from fingerprint patches is obtained. The two modules are not independent but connected through our proposed rethinking module by localizing two discriminative patches for the local module based on the global spoofness score. Finally, the fusion spoofness score by averaging the global and local spoofness scores is used for PAD. Our experimental results evaluated on LivDet 2017 show that the proposed RTK-PAD can achieve an average classification error (ACE) of 2.28% and a true detection rate (TDR) of 91.19% when the false detection rate (FDR) equals 1.0%, which significantly outperformed the state-of-the-art methods by $\sim$10% in terms of TDR (91.19% versus 80.74%).
Low-rank adaptation (LoRA) is an efficient strategy for adapting latent diffusion models (LDMs) on a training dataset to generate specific objects by minimizing the adaptation loss. However, adapted LDMs via LoRA are vulnerable to membership inference (MI) attacks that can judge whether a particular data point belongs to private training datasets, thus facing severe risks of privacy leakage. To defend against MI attacks, we make the first effort to propose a straightforward solution: privacy-preserving LoRA (PrivateLoRA). PrivateLoRA is formulated as a min-max optimization problem where a proxy attack model is trained by maximizing its MI gain while the LDM is adapted by minimizing the sum of the adaptation loss and the proxy attack model's MI gain. However, we empirically disclose that PrivateLoRA has the issue of unstable optimization due to the large fluctuation of the gradient scale which impedes adaptation. To mitigate this issue, we propose Stable PrivateLoRA that adapts the LDM by minimizing the ratio of the adaptation loss to the MI gain, which implicitly rescales the gradient and thus stabilizes the optimization. Our comprehensive empirical results corroborate that adapted LDMs via Stable PrivateLoRA can effectively defend against MI attacks while generating high-quality images. Our code is available at https://github.com/WilliamLUO0/StablePrivateLoRA.
Multi-view 3D object detectors struggle with duplicate predictions due to the lack of depth information, resulting in false positive detections. In this study, we introduce BEAM, a novel Beta Distribution Ray Denoising approach that can be applied to any DETR-style multi-view 3D detector to explicitly incorporate structure prior knowledge of the scene. By generating rays from cameras to objects and sampling spatial denoising queries from the Beta distribution family along these rays, BEAM enhances the model's ability to distinguish spatial hard negative samples arising from ambiguous depths. BEAM is a plug-and-play technique that adds only marginal computational costs during training, while impressively preserving the inference speed. Extensive experiments and ablation studies on the NuScenes dataset demonstrate significant improvements over strong baselines, outperforming the state-of-the-art method StreamPETR by 1.9% mAP. The code will be available at https://github.com/LiewFeng/BEAM.
Thyroid cancer, the most prevalent endocrine cancer, has gained significant global attention due to its impact on public health. Extensive research efforts have been dedicated to leveraging artificial intelligence (AI) methods for the early detection of this disease, aiming to reduce its morbidity rates. However, a comprehensive understanding of the structured organization of research applications in this particular field remains elusive. To address this knowledge gap, we conducted a systematic review and developed a comprehensive taxonomy of machine learning-based applications in thyroid cancer pathogenesis, diagnosis, and prognosis. Our primary objective was to facilitate the research community's ability to stay abreast of technological advancements and potentially lead the emerging trends in this field. This survey presents a coherent literature review framework for interpreting the advanced techniques used in thyroid cancer research. A total of 758 related studies were identified and scrutinized. To the best of our knowledge, this is the first review that provides an in-depth analysis of the various aspects of AI applications employed in the context of thyroid cancer. Furthermore, we highlight key challenges encountered in this domain and propose future research opportunities for those interested in studying the latest trends or exploring less-investigated aspects of thyroid cancer research. By presenting this comprehensive review and taxonomy, we contribute to the existing knowledge in the field, while providing valuable insights for researchers, clinicians, and stakeholders in advancing the understanding and management of this disease.